{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T09:39:28Z","timestamp":1774690768693,"version":"3.50.1"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate rabbit behavioral responses and activity after gabapentin administration.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>METHODS<\/jats:title>\n<jats:p>In this study, 5 intact female and 3 intact male New Zealand white rabbits aged 8 to 12 months were administered a single oral 25-mg\/kg dose of gabapentin. This study was conducted from December 2020 to February 2021. Effects on individual behavior, posture, and motor activity were evaluated with ANY-maze software (video tracking system) and ethograms. Rabbits were assessed 2 hours after gabapentin administration. Rabbits were acclimated to the assessment pen for 3 days prior to testing, and baseline measurements (control) were assessed 1 day prior to the first gabapentin administration. Treatment was performed 3 times daily, with each rabbit given gabapentin once a day for morning, midday, and late afternoon doses. Treatments were repeated with a 1-week interval period in between until all rabbits had received dosing at all 3 time periods. Data were analyzed as continuous with a linear mixed model.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>RESULTS<\/jats:title>\n<jats:p>There was a significant increase in frolicking behavior and significant decrease in observing behavior between baseline and after gabapentin administration. There was no significant change in other rabbit behaviors, postures, or motor patterns.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CONCLUSIONS<\/jats:title>\n<jats:p>Results indicated that oral gabapentin at 25 mg\/kg increased play (frolicking) and decreased vigilance (observing) behaviors without significantly affecting motor patterns, suggesting that this dose reduced stress-associated behaviors without causing excessive sedation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Oral gabapentin appears to reduce fear and anxiety in rabbits in a controlled environment. This shows promise for its ability to reduce stress with veterinary visits, transport, and other stressful events.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.09.0602","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T14:51:43Z","timestamp":1735224703000},"page":"335-342","source":"Crossref","is-referenced-by-count":4,"title":["Single oral dose of gabapentin reduces vigilance and increases play behavior without changing mobility in New Zealand white rabbits (Oryctolagus cuniculus)"],"prefix":"10.2460","volume":"263","author":[{"given":"Rachel E.","family":"Conway","sequence":"first","affiliation":[{"name":"James L. Voss Veterinary Teaching Hospital, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Desmarchelier","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al, Saint-Hyacinthe, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mollie","family":"Burton","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resources, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khursheed","family":"Mama","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangeeta","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lon V.","family":"Kendall","sequence":"additional","affiliation":[{"name":"Laboratory Animal Resources, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda J.","family":"Sadar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Veterinary Psychopharmacology","first-page":"147","article-title":"Anticonvulsants and mood stabilizers","author":"Crowell-Davis SL","year":"2019","unstructured":"Crowell-Davis SL, Irimajiri M, Mattos de Souza Dantes L. 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