{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:00:27Z","timestamp":1783958427777,"version":"3.55.0"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>This study aimed to evaluate whether pretreatment with gabapentin or alprazolam in cats increases sedation, facilitates intravenous catheter placement (IVCP), or reduces propofol requirements for intubation compared to placebo.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>All cats that participated in this prospective, randomized, blinded, controlled clinical trial were admitted for elective ovariohysterectomy at a veterinary teaching hospital from 2022 to 2023. The cats were healthy, were \u2265 6 months old, and weighed &gt; 3 kg. The cats were randomly assigned to 3 groups: group G received gabapentin (100 mg\/cat), group A received alprazolam (0.125 mg\/cat), and group P received a placebo. Ninety minutes after the pretreatment administration, premedication with acepromazine (0.02 mg\/kg) and buprenorphine (0.02 mg\/kg) was administered intramuscularly. Thirty minutes later, sedation levels, IVCP difficulty, and propofol requirements for intubation were evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 60 cats were finally included, with 20 cats in each group. Sedation scores were significantly higher in both group G and group A compared to group P, with no significant difference observed between group G and group A. No differences were observed in the difficulty of IVCP among the groups. Propofol requirements for intubation were significantly lower in group A (4.6 \u00b1 1.2 mg\/kg) compared to both group G (6.7 \u00b1 2.4 mg\/kg) and group P (8.4 \u00b1 1.9 mg\/kg).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Pretreatment with gabapentin or alprazolam increased sedation in cats undergoing premedication. Alprazolam reduced the propofol required for intubation, though neither drug facilitated IVCP.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>The findings of our study can have implications for anesthesia protocols in feline patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.09.0631","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T13:29:43Z","timestamp":1736947783000},"page":"515-520","source":"Crossref","is-referenced-by-count":1,"title":["Gabapentin and alprazolam pretreatment enhance sedation and reduce propofol requirements but do not improve intravenous catheter placement in cats undergoing elective ovariohysterectomy"],"prefix":"10.2460","volume":"263","author":[{"given":"Virginia","family":"Papageorgiou","sequence":"first","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Ververidis","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathios E.","family":"Mylonakis","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Savvas","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kazakos","sequence":"additional","affiliation":[{"name":"Companion Animal Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"10","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"1175","article-title":"Effects of a single preappointment dose of gabapentin on signs of stress in cats during transportation and veterinary examination","volume":"251","author":"van Haaften KA","year":"2017","unstructured":"van Haaften KA, Forsythe LRE, Stelow EA, Bain MJ. 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