{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:31:13Z","timestamp":1792704673392,"version":"4.5.0"},"reference-count":57,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rocky Mountain spotted fever (RMSF) kills people and dogs in rural communities throughout the Americas and in urban epidemics in Brazil and Mexico. The companion Currents in One Health by Foley et al,\n                    <jats:italic>AJVR<\/jats:italic>\n                    , March 2025, addresses the urban ecology of this devastating disease across the Americas. Cases acquired from\n                    <jats:italic>Dermacentor<\/jats:italic>\n                    spp ticks are sylvatic and sporadic, in contrast with peridomestic cases from\n                    <jats:italic>Rhipicephalus sanguineus<\/jats:italic>\n                    sensu lato, which relies on dogs as hosts. Since the early 2000s, RMSF reemerged in northern Mexico with at least 9,152 human cases and case mortality up to 50%. These cases tend to occur where people are impoverished and have marginal access to medical care. Data on RMSF in dogs are sparse, although dogs are sentinels for human risk. The presence of roaming dogs in neighborhoods is associated with human cases, canine seroprevalence, and tick abundance. Dogs and people share hematological and clinical chemical findings and results of targeted diagnostic tests. Diagnosis requires PCR confirmation or rising convalescent titers, although seropositivity can be a cross-reaction with other rickettsial organisms. Suspect cases should be treated with doxycycline immediately. Coinfection with other\n                    <jats:italic>R sanguineus<\/jats:italic>\n                    \u2013transmitted pathogens is common. Veterinarians in clinical practice can help families manage RMSF risk with client education and provide tick preventive medication, although the considerable cost is a barrier. Veterinarians can also advise how to manage tick infestations in a home, recognizing that eradicating\n                    <jats:italic>R. sanguineus<\/jats:italic>\n                    is very difficult. To reduce roaming and canine population sizes, veterinarians should promote canine spay, neuter, and restraint to the home.\n                  <\/jats:p>","DOI":"10.2460\/javma.24.11.0756","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T11:45:13Z","timestamp":1738151113000},"page":"293-300","source":"Crossref","is-referenced-by-count":7,"title":["Focus on brown dog tick\u2013transmitted Rocky Mountain spotted fever in dogs and people: shared threats and solutions"],"prefix":"10.2460","volume":"263","author":[{"given":"Janet","family":"Foley","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-5555","authenticated-orcid":true,"given":"Laura","family":"Backus","sequence":"additional","affiliation":[{"name":"Animal Science Department, College of Agriculture, Food and Environmental Sciences, California Polytechnic State University, San Luis Obispo, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5726-7943","authenticated-orcid":true,"given":"Andr\u00e9s M.","family":"L\u00f3pez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Red de Biolog\u00eda y Conservaci\u00f3n de Vertebrados, Instituto de Ecolog\u00eda AC, Veracruz, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"2","key":"ref1","series-title":"MMWR Recomm Rep","first-page":"1","article-title":"Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis\u2014United States","volume":"65","author":"Biggs HM","year":"2016","unstructured":"Biggs HM, Behravesh CB, Bradley KK,  Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever and other spotted fever group rickettsioses, ehrlichioses, and anaplasmosis\u2014United States. MMWR Recomm Rep. 2016;65(2):1-44."},{"key":"ref2","series-title":"Front Public Health","first-page":"55","article-title":"Challenges posed by tick-borne rickettsiae: eco-epidemiology and public health implications","volume":"3","author":"Eremeeva ME","year":"2015","unstructured":"Eremeeva ME, Dasch GA. Challenges posed by tick-borne rickettsiae: eco-epidemiology and public health implications. Front Public Health. 2015;3:55. doi:10.3389\/fpubh.2015.00055"},{"issue":"1","key":"ref3","series-title":"J Med Entomol","first-page":"17","article-title":"Distribution, seasonality, and hosts of the Rocky Mountain wood tick in the United States","volume":"43","author":"James AM","year":"2006","unstructured":"James AM, Freier JE, Keirans JE, Durden LA, Mertins JW, Schlater JL. Distribution, seasonality, and hosts of the Rocky Mountain wood tick in the United States. J Med Entomol. 2006;43(1):17-24."},{"key":"ref4","series-title":"Parasit Vectors","first-page":"26","article-title":"Biology and ecology of the brown dog tick, Rhipicephalus sanguineus","volume":"3","author":"Dantas-Torres F","year":"2010","unstructured":"Dantas-Torres F. Biology and ecology of the brown dog tick, Rhipicephalus sanguineus. Parasit Vectors. 2010;3:26. doi:10.1186\/1756-3305-3-26"},{"issue":"6","key":"ref5","series-title":"N Engl J Med","first-page":"587","article-title":"Rocky Mountain spotted fever from an unexpected tick vector in Arizona","volume":"353","author":"Demma LJ","year":"2005","unstructured":"Demma LJ, Traeger MS, Nicholson WL,  Rocky Mountain spotted fever from an unexpected tick vector in Arizona. N Engl J Med. 2005;353(6):587-594. doi:10.1056\/NEJMoa050043"},{"issue":"4","key":"ref6","series-title":"Am J Trop Med Hyg","first-page":"779","article-title":"Roaming dogs, intense brown dog tick infestation, and emerging Rocky Mountain spotted fever in Tijuana, M\u00e9xico","volume":"110","author":"Foley J","year":"2024","unstructured":"Foley J, L\u00f3pez-P\u00e9rez AM, Rubino F,  Roaming dogs, intense brown dog tick infestation, and emerging Rocky Mountain spotted fever in Tijuana, M\u00e9xico. Am J Trop Med Hyg. 2024;110(4):779-794. doi:10.4269\/ajtmh.23-0410"},{"issue":"9","key":"ref7","series-title":"PLoS Negl Trop Dis","first-page":"e0010738","article-title":"A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes","volume":"16","author":"Kjemtrup AM","year":"2022","unstructured":"Kjemtrup AM, Padgett K, Paddock CD,  A forty-year review of Rocky Mountain spotted fever cases in California shows clinical and epidemiologic changes. PLoS Negl Trop Dis. 2022;16(9):e0010738. doi:10.1371\/journal.pntd.0010738.Published correction appears in PLoS Negl Trop Dis. 2023;17(1):e0011030. doi:10.1371\/journal.pntd.0011030."},{"issue":"11","key":"ref8","series-title":"Emerg Infect Dis","first-page":"2288","article-title":"Rocky Mountain spotted fever in children along the US-Mexico border, 2017-2023","volume":"30","author":"Chiang L","year":"2024","unstructured":"Chiang L, Ramchandar N, Aramkul J,  Rocky Mountain spotted fever in children along the US-Mexico border, 2017-2023. Emerg Infect Dis. 2024;30(11):2288-2293. doi:10.3201\/eid3011.231760"},{"key":"ref9","article-title":"Severe and fatal confirmed Rocky Mountain spotted fever among people with recent travel to Tecate, Mexico","author":"CDC Health Alert Network","unstructured":"CDC Health Alert Network. Severe and fatal confirmed Rocky Mountain spotted fever among people with recent travel to Tecate, Mexico. https:\/\/emergency.cdc.gov\/han\/2023\/han00502.asp"},{"key":"ref10","series-title":"Revista Instituto Salud Enfermidades Tropicales","first-page":"189","article-title":"Una nueva rickettsiosis en M\u00e9xico. Existencia de la Fiebre Manchada americana en los estados de Sinaloa y Sonora","volume":"4","author":"Bustamante M","year":"1943","unstructured":"Bustamante M, Varela G. Una nueva rickettsiosis en M\u00e9xico. Existencia de la Fiebre Manchada americana en los estados de Sinaloa y Sonora. Revista Instituto Salud Enfermidades Tropicales. 1943;4:189-211."},{"issue":"6","key":"ref11","series-title":"Lancet Infect Dis","first-page":"e189","article-title":"Rocky Mountain spotted fever in Mexico: past, present, and future","volume":"17","author":"\u00c1lvarez-Hern\u00e1ndez G","year":"2017","unstructured":"\u00c1lvarez-Hern\u00e1ndez G, Rold\u00e1n JFG, Milan NSH, Lash RR, Behravesh CB, Paddock CD. Rocky Mountain spotted fever in Mexico: past, present, and future. Lancet Infect Dis. 2017;17(6):e189-e196. doi:10.1016\/S1473-3099(17)30173-1"},{"issue":"7","key":"ref12","series-title":"PLoS Negl Trop Dis","first-page":"e0012276","article-title":"Rocky Mountain spotted fever is a neglected tropical disease in Latin America","volume":"18","author":"\u00c1lvarez-Hern\u00e1ndez G","year":"2024","unstructured":"\u00c1lvarez-Hern\u00e1ndez G, Paddock CD, Walker DH,  Rocky Mountain spotted fever is a neglected tropical disease in Latin America. PLoS Negl Trop Dis. 2024;18(7):e0012276. doi:10.1371\/journal.pntd.0012276"},{"issue":"5","key":"ref13","series-title":"Bol Med Hosp Infant Mex","first-page":"303","article-title":"Fiebre manchada de monta\u00f1as rocosas: experiencia en 5 a\u00f1os de vigilancia activa en un hospital pedi\u00e1trico de segundo nivel en el noreste de M\u00e9xico","volume":"75","author":"L\u00f3pez-Castillo DC","year":"2018","unstructured":"L\u00f3pez-Castillo DC, Vaquera-Aparicio D, Gonz\u00e1lez-Soto MA, Mart\u00ednez-Ram\u00edrez R, Rodr\u00edguez-Mu\u00f1oz L, Sol\u00f3rzano-Santos F. Fiebre manchada de monta\u00f1as rocosas: experiencia en 5 a\u00f1os de vigilancia activa en un hospital pedi\u00e1trico de segundo nivel en el noreste de M\u00e9xico. Bol Med Hosp Infant Mex. 2018;75(5):303-308. doi:10.24875\/BMHIM.M18000034"},{"key":"ref14","article-title":"28 sonorenses han muerto por Rickettsia; urgen a fumigar hogares y cuidar mascotas","author":"Rivera M","unstructured":"Rivera M. 28 sonorenses han muerto por Rickettsia; urgen a fumigar hogares y cuidar mascotas. RadioF\u00f3rmula Sonora. Accessed February 6, 2023. https:\/\/www.radioformula.com.mx\/sonora\/2022\/7\/12\/28-sonorenses-han-muerto-por-rickettsia-urgen-fumigar-hogares-cuidar-mascotas-723543.html"},{"key":"ref15","article-title":"Reportan 135 casos de rickettsia en el estado; 41 de ellos perdieron la vida","author":"Rivas V","unstructured":"Rivas V. Reportan 135 casos de rickettsia en el estado; 41 de ellos perdieron la vida. El Heraldo de Chihuahua. October 4, 2022. Accessed November 1, 2024. https:\/\/oem.com.mx\/elheraldodechihuahua\/local\/reportan-135-casos-de-rickettsia-en-el-estado-41-de-ellos-perdieron-la-vida-14496836"},{"key":"ref16","article-title":"Informaci\u00f3n epidemiol\u00f3gica: direcci\u00f3n general de epidemiolog\u00eda","author":"El Sistema Nacional de Vigilancia Epidemiol\u00f3gica","unstructured":"El Sistema Nacional de Vigilancia Epidemiol\u00f3gica. Informaci\u00f3n epidemiol\u00f3gica: direcci\u00f3n general de epidemiolog\u00eda. Gobierno de M\u00e9xico. Accessed November 1, 2024. https:\/\/www.gob.mx\/salud\/acciones-y-programas\/informacion-epidemiologica"},{"key":"ref17","series-title":"Rev Biomed","first-page":"59","article-title":"Deteccion de especies del genero Rickettsia por PCR en pacientes del sector salud y analisis de factores de riesgo en Mexicali Baja California","volume":"26","author":"G\u00f3mez-Castellanos P","year":"2015","unstructured":"G\u00f3mez-Castellanos P, Tinoco-Gracia L, L\u00f3pez-Valencia G,  Deteccion de especies del genero Rickettsia por PCR en pacientes del sector salud y analisis de factores de riesgo en Mexicali Baja California. Rev Biomed. 2015;26:59."},{"key":"ref18","series-title":"Am J Trop Med Hyg","article-title":"Rocky Mountain spotted fever in Mexico: a call to action","author":"\u00c1lvarez-Hern\u00e1ndez G","unstructured":"\u00c1lvarez-Hern\u00e1ndez G, L\u00f3pez-Ridaura R, Cort\u00e9s-Alcal\u00e1 R,  Rocky Mountain spotted fever in Mexico: a call to action. Am J Trop Med Hyg. Published online September 17, 2024. doi:10.4269\/ajtmh.24-0265"},{"issue":"1","key":"ref19","series-title":"Am J Trop Med Hyg","first-page":"22","article-title":"Unbiased assessment of abundance of Rhipicephalus sanguineus sensu lato ticks, canine exposure to spotted fever group Rickettsia, and risk factors in Mexicali, M\u00e9xico","volume":"101","author":"Foley J","year":"2019","unstructured":"Foley J, Tinoco-Gracia L, Rodriguez-Lomel\u00ed M,  Unbiased assessment of abundance of Rhipicephalus sanguineus sensu lato ticks, canine exposure to spotted fever group Rickettsia, and risk factors in Mexicali, M\u00e9xico. Am J Trop Med Hyg. 2019;101(1):22-32. doi:10.4269\/ajtmh.18-0878"},{"key":"ref20","series-title":"Am J Trop Med Hyg","article-title":"Rickettsial pathogens detected in dogs and tick during an epidemic of Rocky Mountain spotted fever in Ensenada, Baja California, M\u00e9xico","author":"Backus L","unstructured":"Backus L, Rubino F, Lopez-Perez A,  Rickettsial pathogens detected in dogs and tick during an epidemic of Rocky Mountain spotted fever in Ensenada, Baja California, M\u00e9xico. Am J Trop Med Hyg. Forthcoming."},{"issue":"12","key":"ref21","series-title":"PLoS One","first-page":"e115105","article-title":"Clinical presentation, convalescence, and relapse of rocky mountain spotted fever in dogs experimentally infected via tick bite","volume":"9","author":"Levin ML","year":"2014","unstructured":"Levin ML, Killmaster LF, Zemtsova GE, Ritter JM, Langham G. Clinical presentation, convalescence, and relapse of rocky mountain spotted fever in dogs experimentally infected via tick bite. PLoS One. 2014;9(12):e115105. doi:10.1371\/journal.pone.0115105"},{"issue":"7","key":"ref22","series-title":"Mem Inst Oswaldo Cruz","first-page":"696","article-title":"Experimental infection of dogs with a Brazilian strain of Rickettsia rickettsii: clinical and laboratory findings","volume":"103","author":"Piranda EM","year":"2008","unstructured":"Piranda EM, Faccini JLH, Pinter A,  Experimental infection of dogs with a Brazilian strain of Rickettsia rickettsii: clinical and laboratory findings. Mem Inst Oswaldo Cruz. 2008;103(7):696-701. doi:10.1590\/s0074-02762008000700012"},{"issue":"3","key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"375","article-title":"Tick-borne pathogens detected in sheltered dogs during an epidemic of Rocky Mountain spotted fever, a One Health challenge","volume":"261","author":"Backus L","year":"2022","unstructured":"Backus L, Foley J, Chung C, Virata S, Zazueta OE, L\u00f3pez-P\u00e9rez A. Tick-borne pathogens detected in sheltered dogs during an epidemic of Rocky Mountain spotted fever, a One Health challenge. J Am Vet Med Assoc. 2022;261(3):375-383. doi:10.2460\/javma.22.08.0388"},{"issue":"1","key":"ref24","series-title":"BMC Vet Res","first-page":"221","article-title":"Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap Region of the United States","volume":"16","author":"Patterson G","year":"2020","unstructured":"Patterson G, Tanhauser M, Schmidt P,  Serosurvey of arthropod-borne diseases among shelter dogs in the Cumberland Gap Region of the United States. BMC Vet Res. 2020;16(1):221. doi:10.1186\/s12917-020-02440-1"},{"issue":"7","key":"ref25","series-title":"J Am Vet Med Assoc","first-page":"1092","article-title":"Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs","volume":"218","author":"Hinrichsen VL","year":"2001","unstructured":"Hinrichsen VL, Whitworth UG, Breitschwerdt EB, Hegarty BC, Mather TN. Assessing the association between the geographic distribution of deer ticks and seropositivity rates to various tick-transmitted disease organisms in dogs. J Am Vet Med Assoc. 2001;218(7):1092-1097. doi:10.2460\/javma.2001.218.1092"},{"issue":"8","key":"ref26","series-title":"Zoonoses Public Health","first-page":"984","article-title":"Serologic assessment for exposure to spotted fever group rickettsiae in dogs in the Arizona-Sonora border region","volume":"65","author":"Yaglom HD","year":"2018","unstructured":"Yaglom HD, Nicholson WL, Casal M, Nieto NC, Adams L. Serologic assessment for exposure to spotted fever group rickettsiae in dogs in the Arizona-Sonora border region. Zoonoses Public Health. 2018;65(8):984-992. doi:10.1111\/zph.12517"},{"issue":"2","key":"ref27","series-title":"Zoonoses Public Health","first-page":"148","article-title":"Spotted fever group rickettsiae canine serosurveillance near the US-Mexico border in California","volume":"67","author":"Estrada I","year":"2020","unstructured":"Estrada I, Balagot C, Fierro M,  Spotted fever group rickettsiae canine serosurveillance near the US-Mexico border in California. Zoonoses Public Health. 2020;67(2):148-155. doi:10.1111\/zph.12666"},{"issue":"1","key":"ref28","series-title":"Vector Borne Zoonotic Dis","first-page":"29","article-title":"Experimental infection of Rhipicephalus sanguineus ticks with the bacterium Rickettsia rickettsii, using experimentally infected dogs","volume":"11","author":"Piranda EM","year":"2011","unstructured":"Piranda EM, Faccini JLH, Pinter A, Pacheco RC, Can\u00e7ado PH, Labruna MB. Experimental infection of Rhipicephalus sanguineus ticks with the bacterium Rickettsia rickettsii, using experimentally infected dogs. Vector Borne Zoonotic Dis. 2011;11(1):29-36. doi:10.1089\/vbz.2009.0250"},{"issue":"6","key":"ref29","series-title":"Emerg Infect Dis","first-page":"1567","article-title":"Rocky Mountain spotted fever in a large metropolitan center, Mexico-United States border, 2009-2019","volume":"27","author":"Zazueta OE","year":"2021","unstructured":"Zazueta OE, Armstrong PA, M\u00e1rquez-Elguea A,  Rocky Mountain spotted fever in a large metropolitan center, Mexico-United States border, 2009-2019. Emerg Infect Dis. 2021;27(6):1567-1576. doi:10.3201\/eid2706.191662"},{"key":"ref30","series-title":"Ann N Y Acad Sci","first-page":"519","article-title":"Spotted fever group rickettsial infection in dogs from eastern Arizona: how long has it been there?","volume":"1078","author":"Nicholson WL","year":"2006","unstructured":"Nicholson WL, Gordon R, Demma LJ. Spotted fever group rickettsial infection in dogs from eastern Arizona: how long has it been there? Ann N Y Acad Sci. 2006;1078:519-522. doi:10.1196\/annals.1374.102"},{"issue":"2","key":"ref31","series-title":"Am J Trop Med Hyg","first-page":"197","article-title":"Short report: concurrent Rocky Mountain spotted fever in a dog and its owner","volume":"66","author":"Paddock CD","year":"2002","unstructured":"Paddock CD, Brenner O, Vaid C,  Short report: concurrent Rocky Mountain spotted fever in a dog and its owner. Am J Trop Med Hyg. 2002;66(2):197-199. doi:10.4269\/ajtmh.2002.66.197"},{"key":"ref32","series-title":"J Am Vet Med Assoc","first-page":"1450","article-title":"Implications of presumptive fatal Rocky Mountain spotted fever in two dogs and their owner","volume":"223","author":"Elchos BN","year":"2003","unstructured":"Elchos BN, Goddard J. Implications of presumptive fatal Rocky Mountain spotted fever in two dogs and their owner. J Am Vet Med Assoc. 2003;223:1450-1452. doi:10.2460\/javma.2003.223.1450"},{"issue":"3","key":"ref33","series-title":"Emerg Infect Dis","first-page":"458","article-title":"Rocky Mountain spotted fever in dogs, Brazil","volume":"15","author":"Labruna MB","year":"2009","unstructured":"Labruna MB, Kamakura O, Moraes-Filho J, Horta MC, Pacheco RC. Rocky Mountain spotted fever in dogs, Brazil. Emerg Infect Dis. 2009;15(3):458-460. doi:10.3201\/eid1503.081227"},{"issue":"2","key":"ref34","series-title":"J Vector Borne Dis","first-page":"114","article-title":"Clinical characteristics of Rocky Mountain spotted fever in the United States: A literature review","volume":"57","author":"Jay R","year":"2020","unstructured":"Jay R, Armstrong PA. Clinical characteristics of Rocky Mountain spotted fever in the United States: A literature review. J Vector Borne Dis. 2020;57(2):114-120. doi:10.4103\/0972-9062.310863"},{"issue":"1","key":"ref35","series-title":"J Am Anim Hosp Assoc","first-page":"41","article-title":"Canine Rocky Mountain spotted fever: a retrospective study of 30 cases","volume":"37","author":"Gasser AM","year":"2001","unstructured":"Gasser AM, Birkenheuer AJ, Breitschwerdt EB. Canine Rocky Mountain spotted fever: a retrospective study of 30 cases. J Am Anim Hosp Assoc. 2001;37(1):41-48. doi:10.5326\/15473317-37-1-41"},{"issue":"1","key":"ref36","series-title":"J Vet Intern Med","first-page":"145","article-title":"Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii","volume":"34","author":"Lashnits E","year":"2020","unstructured":"Lashnits E, Neupane P, Maggi RG,  Detection of Bartonella spp. in dogs after infection with Rickettsia rickettsii. J Vet Intern Med. 2020;34(1):145-159. doi:10.1111\/jvim.15675"},{"key":"ref37","series-title":"Am J Case Rep","first-page":"917","article-title":"Septic shock caused by Rocky Mountain spotted fever in a suburban Texas patient with pet dog exposure: a case report","volume":"19","author":"Hatcher C","year":"2018","unstructured":"Hatcher C, Karahalios B, Badam M. Septic shock caused by Rocky Mountain spotted fever in a suburban Texas patient with pet dog exposure: a case report. Am J Case Rep. 2018;19:917-919. doi:10.12659\/AJCR.909636"},{"issue":"2","key":"ref38","series-title":"Vet Clin Pathol","first-page":"127","article-title":"Diagnosis of rickettsial diseases in dogs and cats","volume":"42","author":"Allison RW","year":"2013","unstructured":"Allison RW, Little SE. Diagnosis of rickettsial diseases in dogs and cats. Vet Clin Pathol. 2013;42(2):127-144. doi:10.1111\/vcp.12040"},{"key":"ref39","series-title":"Parasit Vectors","first-page":"127","article-title":"Comparison of serological and molecular panels for diagnosis of vector-borne diseases in dogs","volume":"7","author":"Maggi RG","year":"2014","unstructured":"Maggi RG, Birkenheuer AJ, Hegarty BC, Bradley JM, Levy MG, Breitschwerdt EB. Comparison of serological and molecular panels for diagnosis of vector-borne diseases in dogs. Parasit Vectors. 2014;7:127. doi:10.1186\/1756-3305-7-127"},{"issue":"5","key":"ref40","series-title":"Vet Radiol Ultrasound","first-page":"458","article-title":"Orchitis in two dogs with Rocky Mountain spotted fever","volume":"45","author":"Ober CP","year":"2004","unstructured":"Ober CP, Spaulding K, Breitschwerdt EB, Malarkey DE, Hegarty BC. Orchitis in two dogs with Rocky Mountain spotted fever. Vet Radiol Ultrasound. 2004;45(5):458-465. doi:10.1111\/j.1740-8261.2004.04079.x"},{"key":"ref41","series-title":"Canine and Feline Infectious Diseases","first-page":"300","article-title":"Rocky Mountain spotted fever","author":"Kidd L","year":"2014","unstructured":"Kidd L, Breitschwerdt E. Rocky Mountain spotted fever. In: Sykes J, ed. Canine and Feline Infectious Diseases. Elsevier Saunders; 2014:300-310."},{"key":"ref42","article-title":"Data and statistics on spotted fever rickettsiosis","author":"Rocky Mountain spotted fever (RMSF)","unstructured":"Rocky Mountain spotted fever (RMSF). Data and statistics on spotted fever rickettsiosis. CDC. Accessed October 26, 2024. https:\/\/www.cdc.gov\/rocky-mountain-spotted-fever\/data-research\/facts-stats\/index.html"},{"issue":"RR-4","key":"ref43","series-title":"MMWR Recomm Rep","first-page":"1","article-title":"Tickborne Rickettsial Diseases Working Group; CDC. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis\u2014United States: a practical guide for physicians and other health-care and public health professionals","volume":"55","author":"Chapman AS","year":"2006","unstructured":"Chapman AS, Bakken JS, Folk SM, ; Tickborne Rickettsial Diseases Working Group; CDC. Diagnosis and management of tickborne rickettsial diseases: Rocky Mountain spotted fever, ehrlichioses, and anaplasmosis\u2014United States: a practical guide for physicians and other health-care and public health professionals. MMWR Recomm Rep. 2006;55(RR-4):1-27."},{"issue":"7","key":"ref44","series-title":"J Infect Dis","first-page":"1221","article-title":"T cells mediate cross-protective immunity between spotted fever group rickettsiae and typhus group rickettsiae","volume":"190","author":"Valbuena G","year":"2004","unstructured":"Valbuena G, Jordan JM, Walker DH. T cells mediate cross-protective immunity between spotted fever group rickettsiae and typhus group rickettsiae. J Infect Dis. 2004;190(7):1221-1227. doi:10.1086\/423819"},{"issue":"4","key":"ref45","series-title":"Am J Trop Med Hyg","first-page":"767","article-title":"Inadequacy of IgM antibody tests for diagnosis of Rocky Mountain spotted fever","volume":"91","author":"McQuiston JH","year":"2014","unstructured":"McQuiston JH, Wiedeman C, Singleton J,  Inadequacy of IgM antibody tests for diagnosis of Rocky Mountain spotted fever. Am J Trop Med Hyg. 2014;91(4):767-770. doi:10.4269\/ajtmh.14-0123"},{"key":"ref46","series-title":"The Merck Veterinary Manual","author":"Kahn CMLS","year":"2010","unstructured":"Kahn CMLS. The Merck Veterinary Manual. 10th ed. Whitehorse Station; 2010."},{"key":"ref47","series-title":"Vet J","first-page":"45","article-title":"An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis)","volume":"246","author":"Mylonakis ME","year":"2019","unstructured":"Mylonakis ME, Harrus S, Breitschwerdt EB. An update on the treatment of canine monocytic ehrlichiosis (Ehrlichia canis). Vet J. 2019;246:45-53. doi:10.1016\/j.tvjl.2019.01.015"},{"issue":"12","key":"ref48","series-title":"PLoS One","first-page":"e112368","article-title":"Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013","volume":"9","author":"Drexler N","year":"2014","unstructured":"Drexler N, Miller M, Gerding J,  Community-based control of the brown dog tick in a region with high rates of Rocky Mountain spotted fever, 2012-2013. PLoS One. 2014;9(12):e112368. doi:10.1371\/journal.pone.0112368"},{"issue":"4","key":"ref49","series-title":"Trans R Soc Trop Med Hyg","first-page":"293","article-title":"Community-based prevention of epidemic Rocky Mountain spotted fever among minority populations in Sonora, Mexico, using a One Health approach","volume":"114","author":"Alvarez-Hernandez G","year":"2020","unstructured":"Alvarez-Hernandez G, Drexler N, Paddock CD,  Community-based prevention of epidemic Rocky Mountain spotted fever among minority populations in Sonora, Mexico, using a One Health approach. Trans R Soc Trop Med Hyg. 2020;114(4):293-300. doi:10.1093\/trstmh\/trz114"},{"key":"ref50","article-title":"Quick product reference guide","author":"Companion Animal Parasite Council","unstructured":"Companion Animal Parasite Council. Quick product reference guide. Accessed 23 January, 2023. https:\/\/capcvet.org\/parasite-product-applications\/"},{"key":"ref51","series-title":"Ann N Y Acad Sci","first-page":"338","article-title":"Rocky Mountain spotted fever in Arizona: documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site","volume":"1078","author":"Nicholson WL","year":"2006","unstructured":"Nicholson WL, Paddock CD, Demma L,  Rocky Mountain spotted fever in Arizona: documentation of heavy environmental infestations of Rhipicephalus sanguineus at an endemic site. Ann N Y Acad Sci. 2006;1078:338-341. doi:10.1196\/annals.1374.065"},{"issue":"4","key":"ref52","series-title":"Ticks Tick Borne Dis","first-page":"102344","article-title":"A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l","volume":"15","author":"Stone NE","year":"2024","unstructured":"Stone NE, Ballard R, Bourgeois RM,  A mutation associated with resistance to synthetic pyrethroids is widespread in US populations of the tropical lineage of Rhipicephalus sanguineus s.l. Ticks Tick Borne Dis. 2024;15(4):102344. doi:10.1016\/j.ttbdis.2024.102344"},{"issue":"4","key":"ref53","series-title":"Vector Borne Zoonotic Dis","first-page":"423","article-title":"Serologic evidence for exposure to Rickettsia rickettsii in eastern Arizona and recent emergence of Rocky Mountain spotted fever in this region","volume":"6","author":"Demma LJ","year":"2006","unstructured":"Demma LJ, Traeger M, Blau D,  Serologic evidence for exposure to Rickettsia rickettsii in eastern Arizona and recent emergence of Rocky Mountain spotted fever in this region. Vector Borne Zoonotic Dis. 2006;6(4):423-429. doi:10.1089\/vbz.2006.6.423. Published correction appears in Vector Borne Zoonotic Dis. 2007;7(1):106."},{"issue":"2","key":"ref54","series-title":"Zoonoses Public Health","first-page":"85","article-title":"Evidence of exposure to spotted fever group rickettsiae among Arizona dogs outside a previously documented outbreak area","volume":"58","author":"McQuiston JH","year":"2011","unstructured":"McQuiston JH, Guerra MA, Watts MR,  Evidence of exposure to spotted fever group rickettsiae among Arizona dogs outside a previously documented outbreak area. Zoonoses Public Health. 2011;58(2):85-92. doi:10.1111\/j.1863-2378.2009.01300.x"},{"issue":"5","key":"ref55","series-title":"PLoS One","first-page":"e0233567","article-title":"An exploratory analysis of demography and movement patterns of dogs: new insights in the ecology of endemic Rocky Mountain-Spotted Fever in Mexicali, Mexico","volume":"15","author":"L\u00f3pez-P\u00e9rez AM","year":"2020","unstructured":"L\u00f3pez-P\u00e9rez AM, Orozco L, Zazueta OE, Fierro M, Gomez P, Foley J. An exploratory analysis of demography and movement patterns of dogs: new insights in the ecology of endemic Rocky Mountain-Spotted Fever in Mexicali, Mexico. PLoS One. 2020;15(5):e0233567. doi:10.1371\/journal.pone.0233567"},{"key":"ref56","article-title":"Prevalencia de riquetsiosis (Rickettsia rickettsii) en perros asociada al grado de marginilidad en la zona urbana de Mexicali, BC","author":"Tinoco-Gracia L","year":"2009","unstructured":"Tinoco-Gracia L, Hori-Oshima S, Medina-Basulto G,  Prevalencia de riquetsiosis (Rickettsia rickettsii) en perros asociada al grado de marginilidad en la zona urbana de Mexicali, BC. Presented at: XIV Congreso Veterinario de L\u00e9on; 2009."},{"key":"ref57","article-title":"Diagnostico serologico y molecular de un brote de riquetsiosis (Rickettsia rickettsii) en perros y un humano en la cuidad de Mexicali, BC","author":"Tinoco-Gracia L","unstructured":"Tinoco-Gracia L, Hori-Oshima S, Medina-Basulto G,  Diagnostico serologico y molecular de un brote de riquetsiosis (Rickettsia rickettsii) en perros y un humano en la cuidad de Mexicali, BC. Presented at: XXXIV Congreso Anual de Infectologia y Microbiologia Clinica; October 2009; Guadalajara, Mexico."}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/263\/3\/javma.24.11.0756.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/263\/3\/javma.24.11.0756.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/263\/3\/javma.24.11.0756.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:23:08Z","timestamp":1741346588000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/263\/3\/javma.24.11.0756.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":57,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.2460\/javma.24.11.0756","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}