{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:29:11Z","timestamp":1766068151614,"version":"3.41.0"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To assess heart rate variability (HRV) as a marker of autonomic nervous system disruption and its role in disease progression in dogs with Chagas disease (CD), and to evaluate arrhythmias and conduction abnormalities in symptomatic and asymptomatic groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A prospective observational study was conducted on dogs treated at a small animal hospital in central Texas from August to December 2023. Ambulatory 24-hour Holter monitoring was conducted to assess HRV metrics (proportion of pairs of successive NN intervals differing by &gt; 50 milliseconds and root mean square of the successive differences), arrhythmias, and conduction abnormalities. Heart rate variability parameters were categorized as high, normal, or low. Dogs were classified as symptomatic or asymptomatic on the basis of clinical presentation, and comparisons of HRV and ECG findings between groups were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>112 client-owned dogs with confirmed <jats:italic>Trypanosoma cruzi<\/jats:italic> infection were included. Of the 112 dogs, 46 (41.1%) were symptomatic and 66 (58.9%) were asymptomatic. Heart rate variability disruptions were observed in 63% of dogs, underscoring early and widespread autonomic dysregulation in <jats:italic>T cruzi<\/jats:italic> infection. Symptomatic dogs had more arrhythmias (1.54 vs 1.02) and a higher prevalence of second-degree atrioventricular blocks (0.19 vs 0.03), but HRV abnormalities were similar between groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Heart rate variability abnormalities were prominent across all dogs with CD, regardless of symptoms, suggesting their utility as early markers of autonomic and cardiac dysfunction. These findings highlight HRV\u2019s potential for monitoring disease progression, particularly in asymptomatic dogs, supporting its inclusion in routine assessments for <jats:italic>T cruzi<\/jats:italic> infections.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>Heart rate variability analysis may enhance early detection and management of CD, an emerging One Health issue, by addressing underdiagnosed autonomic and cardiac dysfunction in dogs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.24.12.0773","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T19:23:33Z","timestamp":1742412213000},"page":"888-895","source":"Crossref","is-referenced-by-count":1,"title":["Heart rate variability derangements in dogs with Chagas disease: a potential indicator of autonomic and cardiac disruption"],"prefix":"10.2460","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4284-6077","authenticated-orcid":true,"given":"Roy","family":"Madigan","sequence":"first","affiliation":[{"name":"Vida Pharmacal and United Veterinary Care, Spring Branch, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby","family":"West","sequence":"additional","affiliation":[{"name":"School of Public Health, Texas A&M University, College Station, TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-1599","authenticated-orcid":true,"given":"Luis C.","family":"Ascanio","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1344-9312","authenticated-orcid":true,"given":"Juan D.","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5056-9615","authenticated-orcid":true,"given":"Christopher","family":"McMahan","sequence":"additional","affiliation":[{"name":"Clemson University, Clemson, SC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-1736","authenticated-orcid":true,"given":"Alberto","family":"Paniz-Mondolfi","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"4","key":"ref1","series-title":"Infect Immun","first-page":"1349","article-title":"Preferential brain homing following intranasal administration of Trypanosoma cruzi","volume":"77","author":"Caradonna K","year":"2009","unstructured":"Caradonna K, Pereiraperrin M. 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