{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:27:54Z","timestamp":1787495274523,"version":"build-2736575974"},"reference-count":18,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To compare methicillin-resistant\n                    <jats:italic>Staphylococcus pseudintermedius<\/jats:italic>\n                    (MRSP) and methicillin-susceptible\n                    <jats:italic>S pseudintermedius<\/jats:italic>\n                    (MSSP) infections in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Multicenter case-control study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u2014Dogs with MRSP infections were matched, by hospital, with 2 MSSP controls, with the infections occurring immediately before and after the case infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014Signalment, historical, clinical, treatment, and outcome data were documented. Conditional logistic regression was performed. A manual stepwise backward elimination procedure was used to build the multivariable model.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u201456 case and 112 control dogs were enrolled. Pyoderma was the most common infection type in both groups. In the final multivariable model, systemic administration of antimicrobials within 30 days prior to infection was significantly associated with an MRSP versus an MSSP infection (OR, 9.9; 95% confidence interval, 3.59 to 27.53).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014The association of prior antimicrobial administration and MRSP infection indicated the potential impact of routine antimicrobial use in veterinary medicine on antimicrobial resistance and the need for prudent use of these important drugs. Mortality rate was not significantly different between MRSP and MSSP infections; the lack of a significant difference suggested that MRSP was inherently no more virulent than MSSP, provided the infection was properly diagnosed and appropriate treatment was started. Basic concepts such as prudent antimicrobial use and early diagnosis through timely submission of appropriate culture specimens therefore can be important measures to try to reduce the impact of this pathogen.\n                  <\/jats:p>","DOI":"10.2460\/javma.240.12.1450","type":"journal-article","created":{"date-parts":[[2012,6,1]],"date-time":"2012-06-01T10:07:22Z","timestamp":1338545242000},"page":"1450-1455","source":"Crossref","is-referenced-by-count":71,"title":["Factors associated with methicillin-resistant versus methicillin-susceptible Staphylococcus pseudintermedius infection in dogs"],"prefix":"10.2460","volume":"240","author":[{"given":"J. Scott","family":"Weese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith C.","family":"Faires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Battisti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Res Vet Sci","first-page":"174","article-title":"Occurrence of Staphylococcus intermedius on the hair and skin of normal dogs","volume":"52","author":"Allaker","year":"1992"},{"key":"ref2","series-title":"Cornell Vet","first-page":"124","article-title":"Species of Staphylococcus isolated from animal 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Epidemiol","first-page":"140","article-title":"Recommendations for surveillance of Clostridium difficile\u2013associated disease","volume":"28","author":"McDonald","year":"2007"},{"key":"ref16","series-title":"Emerg Infect Dis","first-page":"69","article-title":"Methicillin-resistant and -susceptible Staphylococcus aureus infections in dogs","volume":"16","author":"Faires","year":"2010"},{"key":"ref17","series-title":"Vet Res","first-page":"55","article-title":"Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) infection in dogs and cats: a case-control study","volume":"41","author":"Soares Magalh\u00e3es","year":"2010"},{"key":"ref18","series-title":"J Vet Diagn Invest","first-page":"160","article-title":"Proposed changes to Clinical Laboratory Standards Institute interpretive criteria for methicillin-resistant Staphylococcus pseudintermedius isolated from dogs (lett)","volume":"22","author":"Papich","year":"2010"}],"container-title":["Journal of the American 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