{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:24:34Z","timestamp":1759335874971,"version":"3.38.0"},"reference-count":32,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 9-year-old castrated male Bichon Frise was evaluated because of a 3-week history of a nonhealing corneal ulcer and corneal pigmentation of the left eye.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Ophthalmic examination of the left eye revealed conjunctival hyperemia, corneal neovascularization, corneal edema, corneal ulceration, and central corneal pigmentation. Intraocular structures of the left eye could not be visually examined because of the diffuse nature of the corneal lesions. The right eye had anterior cortical incipient cataracts, nuclear sclerosis, and an inactive chorioretinal scar.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Superficial lamellar keratectomy of the left eye was performed for both therapeutic and diagnostic purposes. Histologic evaluation of corneal biopsy specimens revealed dematiaceous fungal keratitis of the left eye, and topical administration of voriconazole was used to successfully resolve the keratitis. Seven months after diagnosis of dematiaceous fungal keratitis, the dog had no clinical signs or history of recurrence of the keratitis.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014Dematiaceous fungal keratitis should be considered as a possible cause of nonhealing corneal ulceration with heavy pigment deposition in dogs. Results suggested that lamellar keratectomy along with topical administration of voriconazole can be used successfully to treat dematiaceous fungal keratitis in dogs.<\/jats:p>","DOI":"10.2460\/javma.240.9.1104","type":"journal-article","created":{"date-parts":[[2012,4,19]],"date-time":"2012-04-19T14:39:55Z","timestamp":1334846395000},"page":"1104-1108","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of dematiaceous fungal keratitis in a dog"],"prefix":"10.2460","volume":"240","author":[{"given":"Jonathan D.","family":"Pucket","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel A.","family":"Allbaugh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Rankin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Ophthalmol","first-page":"126","article-title":"Curvularia keratomycosis in a dog","volume":"13","author":"Ben-Shlomo","year":"2010"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"507","article-title":"Ocular infections with dematiaceous fungi in two cats and a dog","volume":"213","author":"Bernays","year":"1998"},{"key":"ref3","series-title":"Vet Ophthalmol","first-page":"48","article-title":"Aspergillus flavus keratomycosis in a cat treated with topical 1% voriconazole solution","volume":"12","author":"Labelle","year":"2009"},{"key":"ref4","series-title":"J Am Anim Hosp Assoc","first-page":"331","article-title":"Canine keratomycosis: a report of eight cases and literature review","volume":"30","author":"Marlar","year":"1994"},{"key":"ref5","series-title":"Vet Ophthalmol","first-page":"43","article-title":"Hormographiella aspergillata keratomycosis in a dog","volume":"12","author":"Rampazzo","year":"2009"},{"key":"ref6","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"567","article-title":"Immunological aspects of fungal pathogenesis","volume":"9","author":"Deepe","year":"1990"},{"key":"ref7","series-title":"Dermatol Clin","first-page":"147","article-title":"Phaeohyphomycosis","volume":"14","author":"Rinaldi","year":"1996"},{"key":"ref8","series-title":"Am J Ophthalmol","first-page":"1156","article-title":"Climatology of dematiaceous fungal keratitis","volume":"140","author":"Wilhelmus","year":"2005"},{"key":"ref9","series-title":"Trans Am Ophthalmol Soc","first-page":"111","article-title":"Curvularia keratitis","volume":"99","author":"Wilhelmus","year":"2001"},{"key":"ref10","series-title":"Clin Microbiol Rev","first-page":"708","article-title":"Pathogenic roles for fungal melanins","volume":"13","author":"Jacobson","year":"2000"},{"key":"ref11","series-title":"Ophthalmic Res","first-page":"251","article-title":"Comparative study of Gram stain, potassium hydroxide smear, culture and nested PCR in the diagnosis of fungal keratitis","volume":"44","author":"Badiee","year":"2010"},{"key":"ref12","series-title":"Indian J Ophthalmol","first-page":"315","article-title":"Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study","volume":"51","author":"Bharathi","year":"2003"},{"key":"ref13","series-title":"Clin Tech Small Anim Pract","first-page":"186","article-title":"Corneal fungal disease in small animals","volume":"18","author":"Andrew","year":"2003"},{"issue":"suppl 1","key":"ref14","series-title":"J Med Assoc Thai","first-page":"S217","article-title":"Infectious keratitis at King Chulalongkorn Memorial Hospital: a 12-year retrospective study of 391 cases","volume":"85","author":"Boonpasart","year":"2002"},{"key":"ref15","series-title":"Clin Microbiol Rev","first-page":"730","article-title":"Current perspectives on ophthalmic mycoses","volume":"16","author":"Thomas","year":"2003"},{"key":"ref16","series-title":"Ophthalmology","first-page":"574","article-title":"Keratomycosis: clinical and microbiologic experience with dematiaceous fungi","volume":"107","author":"Garg","year":"2000"},{"key":"ref17","series-title":"Br J Ophthalmol","first-page":"116","article-title":"Activity of antibiotics against Fusarium and Aspergillus","volume":"93","author":"Day","year":"2009"},{"key":"ref18","series-title":"J Am Anim Hosp Assoc","first-page":"158","article-title":"Spontaneous chronic corneal epithelial defects in dogs: a review","volume":"41","author":"Bentley","year":"2005"},{"key":"ref19","series-title":"J Am Vet Med Assoc","first-page":"1568","article-title":"Mineralized corneal sequestrum in a cat","volume":"219","author":"Gemensky","year":"2001"},{"key":"ref20","series-title":"Clin Ophthalmol","first-page":"391","article-title":"Clinical utility of voriconazole eye drops in ophthalmic fungal keratitis","volume":"4","author":"Al-Badriyeh","year":"2010"},{"key":"ref21","series-title":"Vet Clin North Am Small Anim Pract","first-page":"669","article-title":"Antifungals and their use in veterinary ophthalmology","volume":"34","author":"Ford","year":"2004"},{"key":"ref22","series-title":"Arch Ophthalmol","first-page":"672","article-title":"Comparison of natamycin and 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