{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T22:06:51Z","timestamp":1745273211207,"version":"3.38.0"},"reference-count":13,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To determine the prevalence of heart murmurs in chinchillas (<jats:italic>Chinchilla lanigera<\/jats:italic>) and determine whether heart murmurs were associated with cardiac disease.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective multi-institutional case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u2014260 chinchillas.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records of all chinchilla patients evaluated at the Tufts University Foster Hospital for Small Animals between 2001 and 2009, the University of California-Davis William R. Pritchard Veterinary Medical Teaching Hospital between 1996 and 2009, and the University of Wisconsin Veterinary Medical Teaching Hospital between 1998 and 2009 were reviewed.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Prevalence of heart murmurs was 23% (59\/260). Of 15 chinchillas with heart murmurs that underwent echocardiography, 8 had echocardiographic abnormalities, including dynamic right ventricular outflow tract obstruction, mitral regurgitation, hypertrophy of the left ventricle, tricuspid regurgitation, and hypovolemia. Echocardiographic abnormalities were approximately 29 times as likely (OR, 28.7) to be present in chinchillas with a murmur of grade 3 or higher than in chinchillas without a murmur.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results suggested that heart murmurs are common in chinchillas and that chinchillas with heart murmurs often have echocardiographic abnormalities, with valvular disease being the most common. On the basis of these results, we believe that echocardiography should be recommended for chinchillas with heart murmurs, especially older chinchillas with murmurs of grade 3 or higher. Further prospective studies are needed to accurately evaluate the prevalence of cardiac disease in chinchillas with heart murmurs.<\/jats:p>","DOI":"10.2460\/javma.241.10.1344","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T14:43:32Z","timestamp":1351694612000},"page":"1344-1347","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of heart murmurs in chinchillas (Chinchilla lanigera): 59 cases (1996\u20132009)"],"prefix":"10.2460","volume":"241","author":[{"given":"Charly","family":"Pignon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sanchez-Migallon Guzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Baey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Pignon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joerg","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D.","family":"Kittleson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Paul-Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Ferrets, rabbits, and rodents: clinical medicine and surgery","first-page":"232","article-title":"Biology, husbandry and clinical techniques of guinea pigs and chinchillas","author":"Quesenberry","year":"2004"},{"key":"ref2","series-title":"Mammals of the world","volume":"II","author":"Walker","year":"1975"},{"key":"ref3","series-title":"The joy of chinchillas","first-page":"26","author":"Ritchey","year":"1995"},{"key":"ref4","series-title":"Ferrets, rabbits, and rodents: clinical medicine and surgery","first-page":"255","article-title":"Disease problems of the chinchillas","author":"Donnelly","year":"2004"},{"key":"ref5","series-title":"BSAVA manual of exotic pets","first-page":"65","article-title":"Chinchillas","author":"Hoefer","year":"2002"},{"key":"ref6","series-title":"J Vet Intern Med","first-page":"772","article-title":"Echocardiography in the chinchilla","volume":"18","author":"Linde","year":"2004"},{"key":"ref7","series-title":"Textbook of veterinary internal medicine","first-page":"195","article-title":"Abnormal heart sounds and hearts murmurs","author":"Prosek","year":"2005"},{"key":"ref8","series-title":"J Am Vet Med Assoc","first-page":"384","article-title":"Assessment of the prevalence of heart murmurs in overtly healthy cats","volume":"225","author":"C\u00f4t\u00e9","year":"2004"},{"key":"ref9","series-title":"Textbook of veterinary internal medicine","first-page":"1022","article-title":"Acquired valvular heart disease","author":"H\u00e4ggstr\u00f6m","year":"2005"},{"key":"ref10","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"135","article-title":"Cardiovascular physiology and diseases of the rabbit","volume":"12","author":"Pariaut","year":"2009"},{"key":"ref11","series-title":"Vet Clin North Am Exot Anim Pract","first-page":"115","article-title":"Ferret cardiology","volume":"12","author":"Wagner","year":"2009"},{"key":"ref12","series-title":"Diseases of the cat: medicine and surgery","first-page":"820","article-title":"Cardiovascular 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