{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:40:52Z","timestamp":1790725252794,"version":"4.1.0"},"reference-count":28,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of nutritional plane on health and performance of dairy calves after infection with <jats:italic>Cryptosporidium parvum<\/jats:italic>.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized, controlled trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201420 Holstein bull calves.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Calves were assigned to a higher plane of nutrition (HPN; 0.30 Mcal intake energy\/kg of metabolic body weight using a 28% protein-20% fat milk replacer) or conventional nutrition (CN; 0.13 Mcal intake energy\/kg of metabolic body weight using a 20% protein-20% fat milk replacer). Calves were inoculated with <jats:italic>C parvum<\/jats:italic> oocysts at 3 days old. Fecal and health scores, oocyst counts, weight gain, dry matter intake, and hematologic variables were measured for 21 days. Data were analyzed with nonparametric and regression methods.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Body weight (day 1), serum total protein concentration (day 3), and PCV (day 3) were not different between groups. Oocyst shedding was not different between groups. The PCV was higher in the CN group (40%), compared with the HPN group (32%) at the end of the study. Fecal scores (FS) improved faster in the HPN group (median, \u22120.1 FS\/feeding), compared with the CN group (median, \u22120.06 FS\/feeding). The HPN calves had better average daily gain (ADG) than did CN calves (median, 433 g\/d vs \u221248 g\/d, respectively). Feed efficiency (ADG:dry matter intake ratio) was better for HPN calves than CN calves (median, 131.9 g\/kg vs \u221231.4 g\/kg).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014After a pathogen challenge, calves maintained hydration, had faster resolution of diarrhea, grew faster, and converted feed with greater efficiency when fed a higher plane of nutrition.<\/jats:p>","DOI":"10.2460\/javma.241.11.1514","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T16:37:45Z","timestamp":1353688665000},"page":"1514-1520","source":"Crossref","is-referenced-by-count":68,"title":["Effect of nutritional plane on health and performance in dairy calves after experimental infection with Cryptosporidium parvum"],"prefix":"10.2460","volume":"241","author":[{"given":"Theresa L.","family":"Ollivett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl V.","family":"Nydam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Linden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight D.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Van Amburgh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Nutrient requirements of dairy cattle","first-page":"214","article-title":"Nutrient requirements of the young calf","author":"National Research","year":"2001"},{"key":"ref2","series-title":"The development, nutrition, and management of the young calf","first-page":"5","article-title":"Introduction","author":"Davis","year":"1998"},{"key":"ref3","series-title":"J Dairy Sci","first-page":"830","article-title":"Composition of growth of Holstein calves fed milk replacer from birth to 105-kilogram body weight","volume":"84","author":"Diaz","year":"2001"},{"key":"ref4","series-title":"J Anim Sci","first-page":"1454","article-title":"Growth and body composition of dairy calves fed milk replacers containing different amounts of protein at two feeding rates","volume":"84","author":"Bartlett","year":"2006"},{"key":"ref5","series-title":"J Dairy Sci","first-page":"799","article-title":"Impact of conventional or intensive milk replacer programs on Holstein heifer performance through six months of age and during first lactation","volume":"92","author":"Raeth-Knight","year":"2008"},{"key":"ref6","series-title":"J Dairy Sci","first-page":"3054","article-title":"Effects of ad libitum milk intake on dairy calves","volume":"85","author":"Jasper","year":"2002"},{"key":"ref7","series-title":"J Dairy Sci","first-page":"585","article-title":"Effect of increasing energy and protein intake on body growth and carcass composition of heifer calves","volume":"88","author":"Brown","year":"2005"},{"key":"ref8","series-title":"J Dairy Sci","first-page":"207","article-title":"Effects of additional milk replacer feeding on calf health, growth, and selected blood metabolites in calves","volume":"89","author":"Quigley","year":"2006"},{"key":"ref9","series-title":"J Dairy Sci","first-page":"1643","article-title":"Effect of nitazoxanide on cryptosporidiosis in experimentally infected neonatal dairy calves","volume":"92","author":"Ollivett","year":"2009"},{"key":"ref10","series-title":"J Am Vet Med Assoc","first-page":"86","article-title":"Potential risk factors for Cryptosporidium infection in dairy calves","volume":"205","author":"Garber","year":"1994"},{"key":"ref11","series-title":"Prev Vet Med","first-page":"11","article-title":"Association between management practices and within-herd prevalence of Cryptosporidium parvum shedding on dairy farms in southern Ontario","volume":"83","author":"Trotz-Williams","year":"2008"},{"key":"ref12","series-title":"J Dairy Sci","first-page":"2110","article-title":"Heat treatment of bovine colostrum. 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