{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:20:09Z","timestamp":1787761209322,"version":"build-2784847793"},"reference-count":33,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 5-year-old sexually intact male Giant Schnauzer was evaluated because of difficulty breathing and left pelvic limb swelling. Eighteen months previously, the patient had had intermittent left pelvic limb swelling, but the owner declined further testing at that time.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Physical examination revealed severe pitting edema of the left pelvic limb and prepuce and muffled heart sounds on thoracic auscultation. Results of thoracic radiography and thoracocentesis were consistent with chylothorax, and CT imaging of the thorax and abdomen revealed a mass involving the whole left sublumbar area.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014In an attempt to treat the chylothorax, pleural omentalization and pericardectomy were performed. Histologic evaluation of several biopsy specimens harvested in the abdominal and thoracic cavities revealed disseminated lymphangiosarcoma. The patient recovered well from surgery, and mitoxantrone chemotherapy was administered. As of 10 months after surgery, the dog was clinically normal except for mild pelvic limb edema.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014The combination of clinical signs, multiple imaging features, surgical findings, and histologic examination findings enabled the final diagnosis of lymphangiosarcoma. Clinical management that included medical and surgical treatments and chemotherapy resulted in improved quality of life and extended survival time in a dog with metastatic lymphangiosarcoma.<\/jats:p>","DOI":"10.2460\/javma.241.12.1639","type":"journal-article","created":{"date-parts":[[2012,12,6]],"date-time":"2012-12-06T14:39:22Z","timestamp":1354804762000},"page":"1639-1644","source":"Crossref","is-referenced-by-count":12,"title":["Use of surgery and mitoxantrone chemotherapy in a dog with disseminated lymphangiosarcoma"],"prefix":"10.2460","volume":"241","author":[{"given":"V\u00e9ronique","family":"Sicotte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Benamou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyanne C.","family":"Fifle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Plant\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues I.","family":"Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam W.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Anim Hosp Assoc","first-page":"312","article-title":"Chylothorax treated via thoracic duct ligation and omentalization","volume":"46","author":"Stewart","year":"2010"},{"key":"ref2","series-title":"Ann Dermatol Venereol","first-page":"760","article-title":"Lymphangiosarcoma treated with liposomal doxorubicin (Caelyx) [in French]","volume":"134","author":"Verdier","year":"2007"},{"key":"ref3","series-title":"Acta Derm Venereol","first-page":"318","article-title":"Fatal lymphangiosarcoma revealed by lymphoedema of the neck","volume":"89","author":"Lalanne","year":"2009"},{"key":"ref4","series-title":"Eur J Surg Oncol","first-page":"982","article-title":"Stewart-Treves syndrome\u2014treatment and outcome in six patients from a single centre","volume":"30","author":"Roy","year":"2004"},{"key":"ref5","series-title":"Cases J","first-page":"6887","article-title":"Lymphangiosarcoma of the arm presenting with lymphedema in a woman 16 years after mastectomy: a case report","volume":"2","author":"Sepah","year":"2009"},{"key":"ref6","series-title":"J Am Anim Hosp Assoc","first-page":"301","article-title":"Lymphangiosarcoma in a dog presenting with massive head and neck swelling","volume":"34","author":"Fossum","year":"1998"},{"key":"ref7","series-title":"J Am Anim Hosp Assoc","first-page":"81","article-title":"Chylothorax in a dog with pulmonary lymphangiosarcoma","volume":"37","author":"Waldrop","year":"2001"},{"key":"ref8","series-title":"J Vet Med Sci","first-page":"197","article-title":"Lymphangiosarcoma in a dog treated with surgery and chemotherapy","volume":"66","author":"Itoh","year":"2004"},{"key":"ref9","series-title":"Can Vet J","first-page":"42","article-title":"Disseminated lymphangiosarcoma in a dog","volume":"38","author":"Barnes","year":"1997"},{"key":"ref10","series-title":"J S Afr Vet Assoc","first-page":"127","article-title":"Lymphangiosarcoma of dogs: a review","volume":"76","author":"Williams","year":"2005"},{"key":"ref11","series-title":"J S Afr Vet Assoc","first-page":"165","article-title":"Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects","volume":"76","author":"Williams","year":"2005"},{"key":"ref12","series-title":"J Vet Med A Physiol Pathol Clin Med","first-page":"452","article-title":"Cutaneous lymphangiosarcoma in a young dog: clinical, anatomopathological and lectinhistochemical description","volume":"50","author":"Diessler","year":"2003"},{"key":"ref13","series-title":"J Vet Intern Med","first-page":"122","article-title":"Lymphangiosarcoma associated with primary lymphedema in a Bouvier des Flandres","volume":"18","author":"Webb","year":"2004"},{"key":"ref14","series-title":"Skin diseases of the dog and cat: clinical and histopathologic diagnosis","first-page":"754","author":"Gross","year":"2005"},{"key":"ref15","series-title":"J Vet Med Sci","first-page":"1199","article-title":"Lymphangiosarcoma in a dog","volume":"56","author":"Shiga","year":"1994"},{"key":"ref16","series-title":"Textbook of veterinary internal medicine: diseases of the dog and the cat","first-page":"1386","article-title":"Venous and lymphatic disorders","author":"Petrie","year":"2010"},{"key":"ref17","series-title":"Vet Pathol","first-page":"353","article-title":"Lymphangiosarcoma in a young dog","volume":"33","author":"Sagartz","year":"1996"},{"key":"ref18","series-title":"Vet Comp Oncol","first-page":"94","article-title":"Postoperative radiotherapy and mitoxantrone for anal sac adenocarcinoma in the dog: 15 cases (1991\u20132001)","volume":"1","author":"Turek","year":"2003"},{"key":"ref19","series-title":"J Feline Med Surg","first-page":"199","article-title":"Treatment of a well differentiated pulmonary adenocarcinoma in a cat by pneumonectomy and adjuvant mitoxantrone chemotherapy","volume":"6","author":"Clements","year":"2004"},{"key":"ref20","series-title":"Withrow & MacEwen's small animal clinical oncology","first-page":"180","author":"Withrow","year":"2007"},{"key":"ref21","series-title":"J Am Vet Med Assoc","first-page":"570","article-title":"Toxicoses associated with the administration of mitoxantrone to dogs with malignant tumors: a dose escalation study","volume":"205","author":"Ogilvie","year":"1994"},{"key":"ref22","series-title":"J Am Vet Med Assoc","first-page":"1613","article-title":"Toxicoses associated with administration of mitoxantrone to dogs with malignant tumors","volume":"198","author":"Ogilvie","year":"1991"},{"key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"1618","article-title":"Efficacy of mitoxantrone against various neoplasms in dogs","volume":"198","author":"Ogilvie","year":"1991"},{"key":"ref24","series-title":"Am J Pathol","first-page":"121","article-title":"The effect of mitoxantrone treatment in Beagle dogs previously treated with minimally cardiotoxic doses of doxorubicin","volume":"128","author":"Tham","year":"1987"},{"key":"ref25","series-title":"J Am Anim Hosp Assoc","first-page":"236","article-title":"Mitoxantrone and cyclophosphamide combination chemotherapy for the treatment of various canine malignancies","volume":"35","author":"Henry","year":"1999"},{"key":"ref26","series-title":"Kirk's current veterinary therapy XIV","first-page":"675","article-title":"Pleural effusion","author":"Hawkins","year":"2009"},{"key":"ref27","series-title":"Vet Surg","first-page":"21","article-title":"Thoracoscopic thoracic duct ligation and thoracoscopic pericardectomy for treatment of chylothorax in dogs","volume":"39","author":"Allman","year":"2010"},{"key":"ref28","series-title":"J Am Anim Hosp Assoc","first-page":"134","article-title":"Chylothorax associated with a congenital peritoneopericardial diaphragmatic hernia in a dog","volume":"45","author":"Schmiedt","year":"2009"},{"key":"ref29","series-title":"Vet J","first-page":"234","article-title":"Pleural omentalisation with en bloc ligation of the thoracic duct and pericardiectomy for idiopathic chylothorax in nine dogs and four cats","volume":"188","author":"Bussadori","year":"2011"},{"key":"ref30","series-title":"J Am Anim Hosp Assoc","first-page":"263","article-title":"Chylothorax and chylous ascites in a dog with mediastinal lymphangiosarcoma","volume":"32","author":"Myers NC","year":"1996"},{"key":"ref31","series-title":"J Vet Intern Med","first-page":"307","article-title":"Thoracic duct ligation and pericardectomy for treatment of idiopathic chylothorax","volume":"18","author":"Fossum","year":"2004"},{"key":"ref32","series-title":"Vet Surg","first-page":"61","article-title":"Use of omentum as a physiologic drain for treatment of chylothorax in a dog","volume":"28","author":"Williams","year":"1999"},{"key":"ref33","series-title":"J Am Anim Hosp Assoc","first-page":"74","article-title":"Omentalization of the thorax for treatment of idiopathic chylothorax with constrictive pleuritis in a cat","volume":"38","author":"Lafond","year":"2002"}],"container-title":["Journal of the American Veterinary Medical 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