{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:31:52Z","timestamp":1770219112544,"version":"3.49.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2012,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in shelter-housed cats with clinical signs of upper respiratory tract disease (URTD).<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized prospective clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals\u2014<\/jats:bold>48 cats with URTD.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Conjunctival and nasal swab specimens were obtained for culture and susceptibility testing, and cats were randomly assigned to 3 treatment groups (16 cats\/group) on day 1: amoxicillin-clavulanic acid (12.5 mg\/kg [5.68 mg\/lb], PO, q 12 h, for 14 days), cefovecin (8.0 mg\/kg [3.64 mg\/lb], SC, once), or doxycycline (10.0 mg\/kg [4.55 mg\/lb], PO, q 24 h, for 14 days). Oculonasal discharge, sneezing, coughing, dyspnea, demeanor, and food intake were scored twice daily for 14 days (scale, 0 [subjectively normal] to 3 [markedly abnormal]).<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014The most common bacterial isolates were <jats:italic>Mycoplasma<\/jats:italic> spp (n = 22) and <jats:italic>Bordetella bronchiseptica<\/jats:italic> (9). Cats treated with amoxicillin-clavulanic acid or doxycycline had significantly increased body weight by day 14. Cats that received doxycycline had significantly lower overall oculonasal discharge scores than those treated with amoxicillin-clavulanic acid or cefovecin. Cats treated with amoxicillin-clavulanic acid or doxycycline had significantly lower overall sneezing scores than those that received cefovecin. Cats that received amoxicillin-clavulanic acid had significantly decreased demeanor and food intake scores on day 2, whereas this was detected later in other groups (demeanor score on days 5 and 7 and food intake score on days 10 and 11 in the cefovecin and doxycycline groups, respectively).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Oral administration of amoxicillin-clavulanic acid or doxycycline appeared to be more effective than a single SC injection of cefovecin in treating cats with clinical signs of URTD.<\/jats:p>","DOI":"10.2460\/javma.241.2.218","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T17:31:43Z","timestamp":1341509503000},"page":"218-226","source":"Crossref","is-referenced-by-count":28,"title":["Comparison of the efficacy of amoxicillin-clavulanic acid, cefovecin, and doxycycline in the treatment of upper respiratory tract disease in cats housed in an animal shelter"],"prefix":"10.2460","volume":"241","author":[{"given":"Annette L.","family":"Litster","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching Ching","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Constable","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Feline Med Surg","first-page":"109","article-title":"Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters","volume":"7","author":"Bannasch","year":"2005"},{"key":"ref2","series-title":"J Feline Med Surg","first-page":"816","article-title":"Descriptive epidemiology of feline upper respiratory tract disease in an animal shelter","volume":"11","author":"Dinnage","year":"2009"},{"key":"ref3","series-title":"J Small Anim Pract","first-page":"327","article-title":"Prevalence of Chlamydia psittaci in different cat populations in Britain","volume":"29","author":"Wills","year":"1988"},{"key":"ref4","series-title":"Vet Rec","first-page":"669","article-title":"Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries","volume":"156","author":"Helps","year":"2005"},{"key":"ref5","series-title":"J Am Vet Med Assoc","first-page":"579","article-title":"Assessment of infectious organisms associated with chronic rhinosinusitis in cats","volume":"227","author":"Johnson","year":"2005"},{"key":"ref6","series-title":"Am J Vet Res","first-page":"643","article-title":"Prevalence of feline herpesvirus 1, Chlamydophila felis, and Mycoplasma spp DNA in conjunctival cells collected from cats with and without conjunctivitis","volume":"68","author":"Low","year":"2007"},{"key":"ref7","series-title":"J Feline Med Surg","first-page":"775","article-title":"Detection of bacterial and viral organisms from the conjunctiva of cats with conjunctivitis and upper respiratory tract disease","volume":"12","author":"Hartmann","year":"2010"},{"key":"ref8","series-title":"Prev Vet Med","first-page":"327","article-title":"Risk factors for time to diagnosis of feline upper respiratory tract disease in UK animal adoption shelters","volume":"87","author":"Edwards","year":"2008"},{"key":"ref9","series-title":"Vet Rec","first-page":"269","article-title":"Bacteriological and antibiotic sensitivity test results in 271 cats with respiratory tract infections","volume":"158","author":"Schultz","year":"2006"},{"key":"ref10","series-title":"J Feline Med Surg","first-page":"472","article-title":"Evaluation of pradofloxacin for the treatment of feline rhinitis","volume":"10","author":"Spindel","year":"2008"},{"key":"ref11","series-title":"J Feline Med Surg","first-page":"542","article-title":"Efficacy of amoxicillin and azithromycin for the empirical treatment of cats with suspected bacterial upper respiratory tract infections","volume":"10","author":"Ruch-Gallie","year":"2008"},{"key":"ref12","series-title":"Vet Rec","first-page":"73","article-title":"Controlled study of the efficacy of clavulanic acid-potentiated amoxicillin in the treatment of Chlamydia psittaci in cats","volume":"149","author":"Sturgess","year":"2001"},{"key":"ref13","series-title":"Prev Vet Med","first-page":"141","article-title":"Molecular epidemiology of feline bordetellosis in two animal shelters in California, USA","volume":"54","author":"Foley","year":"2002"},{"key":"ref14","series-title":"Vet Microbiol","first-page":"57","article-title":"Determination of Mycoplasma bovis susceptibilities against six antimicrobial agents using the E test method","volume":"105","author":"Francoz","year":"2005"},{"key":"ref15","series-title":"J Feline Med Surg","first-page":"605","article-title":"Chlamydophila felis infection. 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