{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:20Z","timestamp":1775768960661,"version":"3.50.1"},"reference-count":26,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2013,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Case Description<\/jats:bold>\n                    \u2014A 4-year-old sexually intact male mixed-breed dog was evaluated because of clinical signs of acute-onset pelvic limb ataxia, rapidly progressing to paraplegia with severe spinal hyperesthesia.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Findings<\/jats:bold>\n                    \u2014General physical examination revealed pyrexia, tachycardia, and tachypnea. Neurologic examination demonstrated severe spinal hyperesthesia and paraplegia with decreased nociception. Magnetic resonance imaging revealed extradural spinal cord compression at T13-L1 and hyperintense lesions on T1- and T2-weighted images in the epaxial musculature and epidural space.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Treatment and Outcome<\/jats:bold>\n                    \u2014Decompressive surgery, consisting of a continuous dorsal laminectomy, with copious lavage of the vertebral canal was performed. Cultures of blood, urine, and surgical site samples were negative. Histologic examination results for samples obtained during surgery demonstrated suppurative myositis and steatitis. These findings confirmed a diagnosis of sterile idiopathic inflammation of the epidural fat and epaxial muscles with spinal cord compression. The dog's neurologic status started to improve 1 week after surgery. After surgery, the dog received supportive care including antimicrobials and NSAIDs. The dog was ambulatory 1 month after surgery and was fully ambulatory despite signs of mild bilateral pelvic limb ataxia 3 years after surgery.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Relevance<\/jats:bold>\n                    \u2014Although idiopathic sterile inflammation of adipose tissue, referred to as panniculitis, more commonly affects subcutaneous tissue, its presence in the vertebral canal is rare. Specific MRI findings described in this report may help in reaching a presumptive diagnosis of this neurologic disorder. A definitive diagnosis and successful long-term outcome in affected patients can be achieved by decompressive surgery and histologic examination of surgical biopsy samples.\n                  <\/jats:p>","DOI":"10.2460\/javma.242.10.1405","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T14:27:56Z","timestamp":1367418476000},"page":"1405-1409","source":"Crossref","is-referenced-by-count":9,"title":["Idiopathic sterile inflammation of the epidural fat and epaxial muscles causing paraplegia in a mixed-breed dog"],"prefix":"10.2460","volume":"242","author":[{"given":"Ine","family":"Cornelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"De Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Gielen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Gadeyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Chiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Vandenabeele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaatje","family":"Kromhout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc M. L.","family":"Van Ham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Surgical approaches to the central nervous system","first-page":"1157","author":"Coates","year":"2003"},{"key":"ref2","series-title":"Miscellaneous skin diseases","first-page":"1156","author":"Scott","year":"2000"},{"key":"ref3","series-title":"Diseases of the panniculus","first-page":"538","author":"Gross","year":"2005"},{"key":"ref4","series-title":"Canine sterile nodular panniculitis: a retrospective study of 14 cases","first-page":"1","volume":"23","author":"O'Kell","year":"2009"},{"key":"ref5","series-title":"A retrospective study and gene analysis of canine sterile panniculitis","first-page":"915","volume":"69","author":"Yamagishi","year":"2007"},{"key":"ref6","series-title":"Epidural idiopathic sterile pyogranulomatous inflammation causing spinal cord compressive injury in five miniature Dachshunds","first-page":"594","volume":"37","author":"Aikawa","year":"2008"},{"key":"ref7","series-title":"Spinal epidural empyema","first-page":"196","volume":"17","author":"Pilkington","year":"2003"},{"key":"ref8","series-title":"Suspected paraspinal abscess and spinal epidural empyema in a dog","first-page":"149","volume":"38","author":"Cherrone","year":"2002"},{"key":"ref9","series-title":"Spinal epidural empyema in two dogs","first-page":"305","volume":"34","author":"Dewey","year":"1998"},{"key":"ref10","series-title":"Magnetic resonance imaging features of spinal epidural empyema in five dogs","first-page":"135","volume":"49","author":"De Stefani","year":"2008"},{"key":"ref11","series-title":"Spinal epidural empyema in seven dogs","first-page":"176","volume":"35","author":"Lavely","year":"2006"},{"key":"ref12","series-title":"Spinal osteomyelitis and epidural empyema in a dog due to migrating conifer material","first-page":"693","volume":"166","author":"Sutton","year":"2010"},{"key":"ref13","series-title":"Bacterial spinal epidural abscess. Review of 43 cases and literature survey","first-page":"369","volume":"71","author":"Darouiche","year":"1992"},{"key":"ref1","series-title":"Surgical approaches to the central nervous system","first-page":"1157","author":"Coates","year":"2003"},{"key":"ref2","series-title":"Miscellaneous skin diseases","first-page":"1156","author":"Scott","year":"2000"},{"key":"ref3","series-title":"Diseases of the panniculus","first-page":"538","author":"Gross","year":"2005"},{"key":"ref4","series-title":"Canine sterile nodular panniculitis: a retrospective study of 14 cases","first-page":"1","volume":"23","author":"O'Kell","year":"2009"},{"key":"ref5","series-title":"A retrospective study and gene analysis of canine sterile panniculitis","first-page":"915","volume":"69","author":"Yamagishi","year":"2007"},{"key":"ref6","series-title":"Epidural idiopathic sterile pyogranulomatous inflammation causing spinal cord compressive injury in five miniature Dachshunds","first-page":"594","volume":"37","author":"Aikawa","year":"2008"},{"key":"ref7","series-title":"Spinal epidural empyema","first-page":"196","volume":"17","author":"Pilkington","year":"2003"},{"key":"ref8","series-title":"Suspected paraspinal abscess and spinal epidural empyema in a dog","first-page":"149","volume":"38","author":"Cherrone","year":"2002"},{"key":"ref9","series-title":"Spinal epidural empyema in two dogs","first-page":"305","volume":"34","author":"Dewey","year":"1998"},{"key":"ref10","series-title":"Magnetic resonance imaging features of spinal epidural empyema in five dogs","first-page":"135","volume":"49","author":"De Stefani","year":"2008"},{"key":"ref11","series-title":"Spinal epidural empyema in seven dogs","first-page":"176","volume":"35","author":"Lavely","year":"2006"},{"key":"ref12","series-title":"Spinal osteomyelitis and epidural empyema in a dog due to migrating conifer material","first-page":"693","volume":"166","author":"Sutton","year":"2010"},{"key":"ref13","series-title":"Bacterial spinal epidural abscess. Review of 43 cases and literature survey","first-page":"369","volume":"71","author":"Darouiche","year":"1992"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/242\/10\/javma.242.10.1405.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/242\/10\/javma.242.10.1405.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/242\/10\/javma.242.10.1405.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:08:41Z","timestamp":1775765321000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/242\/10\/javma.242.10.1405.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,15]]},"references-count":26,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.2460\/javma.242.10.1405","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5,15]]}}}