{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:10:36Z","timestamp":1782601836521,"version":"3.54.5"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To describe the use of sclerotherapy for the renal-sparing treatment of idiopathic renal hematuria (IRH) in dogs and report clinical outcomes.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u20146 dogs (8 renal pelvises) with IRH.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical records of dogs that underwent sclerotherapy were reviewed. Each ureterovesicular junction was identified cystoscopically to determine the side of bleeding, and a retrograde ureteropyelogram was performed with endoscopic and fluoroscopic guidance. A ureteropelvic junction balloon was used for ureteral occlusion, and pelvis filling volumes were recorded. A povidone iodine mixture, followed by a sterile silver nitrate solution, was infused into the renal pelvis. A double-pigtail ureteral stent was placed after the procedure. Information on preprocedure and postprocedure biochemical changes, imaging parameters, and clinical outcomes was obtained.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u20146 dogs (5 males and 1 female) had sclerotherapy for unilateral (4) or bilateral (2) bleeding. Five were right-sided and 3 were left-sided. The median age and weight of dogs were 3 years and 42.4 kg (93.28 lb), respectively. Median procedure time was 150 minutes. One dog that did not have a ureteral stent placed following the procedure developed short-term signs of renal pain and pyelectasis. Cessation of macroscopic hematuria occurred in 4 of 6 dogs (median, 6 hours). Two additional dogs improved moderately. Median follow-up time was 8 months (range, 3.5 to 20.5 months).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Topical sclerotherapy for IRH was safe and effective. Local sclerotherapy for IRH in dogs could be considered a valuable and minimally invasive renal-sparing treatment over ureteronephrectomy.<\/jats:p>","DOI":"10.2460\/javma.242.11.1556","type":"journal-article","created":{"date-parts":[[2013,5,17]],"date-time":"2013-05-17T15:28:21Z","timestamp":1368804501000},"page":"1556-1563","source":"Crossref","is-referenced-by-count":27,"title":["Endoscopic-guided sclerotherapy for renal-sparing treatment of idiopathic renal hematuria in dogs: 6 cases (2010\u20132012)"],"prefix":"10.2460","volume":"242","author":[{"given":"Allyson C.","family":"Berent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chick W.","family":"Weisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erinne","family":"Branter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry G.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alissa","family":"Aarhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Smee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demetrius H.","family":"Bagley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"868","article-title":"Massive hematuria of nontraumatic renal origin in dogs","volume":"183","author":"Stone","year":"1983"},{"key":"ref2","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1748-5827.1987.tb03880.x","article-title":"Idiopathic renal hemorrhage in the dog","volume":"28","author":"Holt","year":"1987"},{"key":"ref3","series-title":"Textbook of veterinary internal medicine","first-page":"129","article-title":"Hematuria and dysuria","volume":"1","author":"Meyer","year":"1983"},{"key":"ref4","series-title":"Compend Contin Educ Pract Vet","first-page":"1317","article-title":"Benign essential hematuria in dogs","volume":"16","author":"Kaufman","year":"1994"},{"key":"ref5","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"511","DOI":"10.5326\/15473317-34-6-511","article-title":"Recurrent urethral obstruction secondary to idiopathic renal hematuria in a puppy","volume":"34","author":"Hawthorne","year":"1998"},{"key":"ref6","series-title":"J Vet Med Sci","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1292\/jvms.59.293","article-title":"Idiopathic renal hematuria in a dog: the usefulness of a method of partial occlusion of the renal artery","volume":"59","author":"Mishina","year":"1997"},{"key":"ref7","series-title":"Compend Contin Educ Pract Vet","first-page":"14","article-title":"Hematuria of renal origin","volume":"8","author":"Hitt","year":"1986"},{"key":"ref8","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/S0022-5347(01)62762-9","article-title":"Ureteroscopic evaluation and treatment of chronic unilateral hematuria","volume":"160","author":"Tawfiek","year":"1998"},{"key":"ref9","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0022-5347(17)40016-4","article-title":"Flexible ureteropyeloscopy in the diagnosis of benign essential hematuria","volume":"143","author":"Bagley","year":"1990"},{"key":"ref10","series-title":"Urol Clin North Am","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0094-0143(03)00098-3","article-title":"Ureteroscopy of benign hematuria","volume":"31","author":"Dooley","year":"2004"},{"key":"ref11","series-title":"Acta Chir Scand","first-page":"657","article-title":"Renal angioma. Four cases of renal angioma of the renal pelvis","volume":"126","author":"Hagen","year":"1963"},{"key":"ref12","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0022-5347(17)66057-9","article-title":"Hemangioma of the kidney","volume":"81","author":"Wallach","year":"1959"},{"key":"ref13","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.cvsm.2004.03.009","article-title":"Diagnostic approach to hematuria in dogs and cats","volume":"34","author":"Forrester","year":"2004"},{"key":"ref14","series-title":"Mil Med","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1093\/milmed\/157.10.561","article-title":"Idiopathic renal hematuria in a military working dog","volume":"157","author":"Jennings","year":"1992"},{"key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"1371","article-title":"Idiopathic hematuria of unilateral renal origin in a dog","volume":"187","author":"Hitt","year":"1985"},{"key":"ref16","series-title":"Vet Rec","first-page":"603","article-title":"Idiopathic renal hematuria in a dog","volume":"135","author":"Batamuzi","year":"1994"},{"key":"ref17","series-title":"Through the cystoscope: diagnostic and therapeutic techniques in endourology","first-page":"511","author":"Adams","year":"2004"},{"key":"ref18","series-title":"Current veterinary therapy XIV","first-page":"965","article-title":"Interventional radiology in urinary diseases","author":"Weisse","year":"2009"},{"key":"ref19","series-title":"Textbook of small animal surgery","first-page":"1558","article-title":"Anatomy of the urinary tract","author":"Christie","year":"2003"},{"key":"ref20","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2460\/javma.239.3.344","article-title":"Transvesicular percutaneous cystolithotomy for the retrieval of cystic and urethral calculi in dogs and cats: 27 cases (2006\u20132008)","volume":"239","author":"Runge","year":"2011"},{"key":"ref21","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/S0022-5347(17)44447-8","article-title":"Silver nitrate irrigation for hematuria from sickle cell hemoglobinopathy","volume":"137","author":"Bahnson","year":"1987"},{"key":"ref22","series-title":"Urology","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0090-4295(81)90384-8","article-title":"Control of prolonged, benign, renal hematuria by silver nitrate instillation","volume":"18","author":"Diamond","year":"1981"},{"key":"ref23","series-title":"BJU Int","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/j.1464-410X.2004.05108.x","article-title":"Is povidone iodine an alternative to silver nitrate for renal pelvic instillation sclerotherapy in cyluria?","volume":"94","author":"Goel","year":"2004"},{"key":"ref24","series-title":"Urol","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1016\/j.urology.2004.07.035","article-title":"Povidone iodine and dextrose solution combination sclerotherapy in chyluria","volume":"64","author":"Nandy","year":"2004"},{"key":"ref25","series-title":"Int Braz J Urol","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1590\/S1677-55382008000300003","article-title":"Fluoroscopy guided instillation therapy in chyluria using combination of povidone iodine with contrast agent. Is a single instillation sufficient?","volume":"34","author":"Sharma","year":"2008"},{"key":"ref26","series-title":"Urol Int","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1159\/000296287","article-title":"Silver nitrate sclerotherapy for chyluria: evaluation for the optimal instillation regime","volume":"85","author":"Dhabalia","year":"2010"},{"key":"ref27","series-title":"Int J Oral Maxillofac Surg","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.ijom.2006.01.015","article-title":"Is povidone-iodine a hemostyptic? A clinical study","volume":"35","author":"Kumar","year":"2006"},{"key":"ref28","series-title":"Kaohsiung J Med Sci","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S1607-551X(09)70251-7","article-title":"Acute necrotizing ureteritis with obstructive uropathy following instillation of silver nitrate in chyluria: a case report","volume":"20","author":"Su","year":"2004"},{"key":"ref29","series-title":"Nat Clin Pract Urol","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/ncpuro1044","article-title":"Persistent prostatic hematuria","volume":"5","author":"Rastinehad","year":"2008"},{"key":"ref30","series-title":"Australas Radiol","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1440-1673.1998.tb00502.x","article-title":"Arterial haemorrhage following instillation of silver nitrate in chyluria: treatment by coil embolization","volume":"42","author":"Srivastava","year":"1998"},{"key":"ref31","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1097\/01.ju.0000169130.80049.9c","article-title":"Passive dilation by ureteral stenting before ureteroscopy: eliminating the need for active dilation","volume":"174","author":"Hubert","year":"2005"},{"key":"ref32","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1016\/S0022-5347(17)38950-4","article-title":"Flexible, actively deflectable fiberoptic ureteronephroscopy","volume":"142","author":"Kavoussi","year":"1989"},{"key":"ref33","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0022-5347(17)54493-6","article-title":"Nephroscopy in chronic unilateral hematuria","volume":"126","author":"Gittes","year":"1981"},{"key":"ref34","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.juro.2007.03.098","article-title":"Ureteroscopic evaluation and laser treatment of chronic unilateral hematuria","volume":"178","author":"Mugiya","year":"2007"},{"key":"ref35","series-title":"Am J Chin Med","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1142\/S0192415X76000184","article-title":"The haemostatic effects of the Chinese herbal drug Yunnan baiyao: a pilot study","volume":"4","author":"Ogle","year":"1976"},{"key":"ref36","series-title":"Comp Med East West","first-page":"155","article-title":"The haemostatic effects of orally administered Yunnan baiyao in rats and rabbits","volume":"5","author":"Ogle","year":"1977"},{"key":"ref37","series-title":"Comp Med East West","first-page":"169","article-title":"Effects of Yunnan baiyao on blood platelets: an ultrastructural study","volume":"5","author":"Chew","year":"1977"},{"key":"ref38","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0022-5347(17)40018-8","article-title":"Safe and effective prolonged administration of epsilon aminocaproic acid in bleeding from the urinary tract","volume":"143","author":"Stefanini","year":"1990"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/242\/11\/javma.242.11.1556.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/242\/11\/javma.242.11.1556.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/242\/11\/javma.242.11.1556.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:37:16Z","timestamp":1741347436000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/242\/11\/javma.242.11.1556.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,1]]},"references-count":38,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.2460\/javma.242.11.1556","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,1]]}}}