{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:40:12Z","timestamp":1788918012227,"version":"build-2803163510"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To analyze survival time and identify prognostic factors associated with outcome following discharge in dogs with primary brain tumors treated palliatively.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Prospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201451 dogs with 5 histopathologic types of brain tumors.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Owners with dogs examined from 2004 to 2008 were invited to participate if dogs had CT or MRI evidence of a brain mass that was histopathologically confirmed as a neoplasm upon death, dogs survived for \u2265 48 hours after hospital discharge, and treatments following discharge were limited to administration of prednisone or phenobarbital. Prognostic factors, including signalment, clinical signs (including duration), tumor type, tumor location, degree of peritumoral edema, lesion burden, and prescribed treatment, were evaluated. Survival time was estimated and animal- and tumor-specific variables evaluated as potential prognostic factors.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014The median survival time in all dogs was 69 days (95% confidence interval [CI], 18 to 201 days). Multivariate analyses identified neuroanatomic location as the only significant prognostic variable, with the survival time of dogs with infratentorial tumors (n = 18) being significantly shorter (median, 28 days; 95% CI, 19 to 68 days) than survival time of dogs with supratentorial (33) tumors (median, 178 days; 95% CI, 119 to 270 days). Seizures were the most common clinical sign associated with supratentorial tumors (24\/33 [73%]) and central vestibular dysfunction with infratentorial tumors (12\/18).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Dogs with palliatively treated primary brain tumors, particularly those with tumors in the cerebellum, pons, or medulla, had a poor prognosis. However, dogs with supratentorial tumors had survival times &gt; 3 months.<\/jats:p>","DOI":"10.2460\/javma.242.2.193","type":"journal-article","created":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T14:02:53Z","timestamp":1356962573000},"page":"193-198","source":"Crossref","is-referenced-by-count":72,"title":["Survival time following hospital discharge in dogs with palliatively treated primary brain tumors"],"prefix":"10.2460","volume":"242","author":[{"given":"John H.","family":"Rossmeisl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeryl C.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt L.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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