{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:04:55Z","timestamp":1788199495859,"version":"build-2803163510"},"reference-count":25,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2013,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To investigate long-term outcomes and owner-perceived quality of life associated with sudden acquired retinal degeneration syndrome (SARDS) in dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Design<\/jats:bold>\n                    \u2014Survey study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u2014100 dogs with SARDS examined at 5 academic veterinary institutions from 2005 to 2010.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedures<\/jats:bold>\n                    \u2014The diagnosis was based on documented acute vision loss, normal results of ophthalmic examinations, and evaluation of extinguished bright-flash electroretinograms. Primary owners of affected dogs completed a questionnaire addressing outcome measures including vision, systemic signs, and perceived quality of life for their dogs.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Age at diagnosis was significantly correlated with positive outcome measures; dogs in which SARDS was diagnosed at a younger age were more likely to have alleged partial vision and higher owner-perceived quality of life. Polyphagia was the only associated systemic sign found to increase in severity over time. Medical treatment was attempted in 22% of dogs; visual improvement was not detected in any. Thirty-seven percent of respondents reported an improved relationship with their dog after diagnosis, and 95% indicated they would discourage euthanasia of dogs with SARDS.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Blindness and concurrent systemic signs associated with SARDS appeared to persist indefinitely, but only polyphagia increased in severity over time. Most owners believed their pets had good quality of life and would discourage euthanasia of dogs with SARDS.\n                  <\/jats:p>","DOI":"10.2460\/javma.243.10.1426","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T10:56:34Z","timestamp":1383130594000},"page":"1425-1431","source":"Crossref","is-referenced-by-count":32,"title":["Long-term outcome of sudden acquired retinal degeneration syndrome in dogs"],"prefix":"10.2460","volume":"243","author":[{"given":"Jane A.","family":"Stuckey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline W.","family":"Pearce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah 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Ophthalmol","first-page":"11","article-title":"Sudden acquired retinal degeneration in the dog: clinical and laboratory findings in 36 cases","volume":"1","author":"van der Woerdt","year":"1991"},{"key":"ref5","series-title":"Trans Am Coll Vet Ophthalmol","first-page":"86","article-title":"Sudden acquired retinal degeneration in the dog: clinical and morphologic characterization of the \u201csilent retina\u201d syndrome","volume":"15","author":"Acland","year":"1984"},{"key":"ref6","series-title":"Vet Immunol Immunopathol","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.vetimm.2008.02.020","article-title":"Neuron-specific enolase antibodies in patients with sudden acquired retinal degeneration syndrome","volume":"124","author":"Braus","year":"2008"},{"key":"ref7","series-title":"J Am Anim Hosp Assoc","first-page":"199","article-title":"Clinical features suggesting hyperadrenocorticism associated with sudden acquired retinal degeneration syndrome in a dog","volume":"28","author":"Mattson","year":"1992"},{"key":"ref8","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.cvsm.2007.12.003","article-title":"Antibody-mediated retinopathies in canine patients: mechanism, diagnosis, and treatment modalities","volume":"38","author":"Grozdanic","year":"2008"},{"key":"ref9","series-title":"Am J Vet Res","first-page":"149","article-title":"Photoreceptor cell death by apoptosis in dogs with sudden acquired retinal degeneration syndrome","volume":"59","author":"Miller","year":"1998"},{"key":"ref10","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"28","article-title":"Anti-retinal immunoglobulins in canine ocular diseases","volume":"3","author":"Belhorn","year":"1988"},{"key":"ref11","series-title":"Vet Ophthalmol","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1463-5224.2006.00466.x","article-title":"Evaluation of canine serum for the presence of antiretinal autoantibodies in sudden acquired retinal degeneration syndrome","volume":"9","author":"Keller","year":"2006"},{"key":"ref12","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"877","DOI":"10.2460\/ajvr.67.5.877","article-title":"Evaluation of a comparative pathogenesis between cancer-associated retinopathy in humans and sudden acquired retinal degeneration syndrome in dogs via diagnostic imaging and western blot analysis","volume":"67","author":"Gilmour","year":"2006"},{"key":"ref13","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"722","DOI":"10.2460\/javma.2005.226.722","article-title":"Quality-of-life assessment in pet dogs","volume":"226","author":"Wojciechowska","year":"2005"},{"key":"ref14","series-title":"Aging Cell","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1046\/j.1474-9728.2003.00061.x","article-title":"Age-related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy","volume":"2","author":"Speakman","year":"2003"},{"key":"ref15","series-title":"Altern Med Rev","first-page":"5","article-title":"Epidemiology, etiology, and natural treatment of seasonal affective disorder","volume":"10","author":"Miller","year":"2005"},{"key":"ref16","series-title":"J Biol Rhythms","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/0748730408328914","article-title":"Circadian rhythm profiles in women with night eating syndrome","volume":"24","author":"Goel","year":"2009"},{"key":"ref17","series-title":"Am J Obstet Gynecol","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/S0002-9378(16)32480-2","article-title":"Metabolic effects of progesterone","volume":"142","author":"Kalkhoff","year":"1982"},{"key":"ref18","series-title":"Science","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1126\/science.1246617","article-title":"Stress-induced hyperphagia and obesity in rats: a possible model for understanding human obesity","volume":"191","author":"Rowland","year":"1976"},{"key":"ref19","series-title":"Res Vet Sci","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.rvsc.2011.04.017","article-title":"Blindness in dogs with pituitary dependent hyperadrenocorticism: relationship with glucose, cortisol and triglyceride concentration and with ophthalmic blood flow","volume":"92","author":"Cabrera Blatter","year":"2012"},{"key":"ref20","series-title":"Vet Dermatol","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/j.1365-3164.2006.00522.x","article-title":"A retrospective analysis of case series using home-prepared and chicken hydrolysate diets in the diagnosis of adverse food reactions in 181 pruritic dogs","volume":"17","author":"Loeffler","year":"2006"},{"key":"ref21","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/j.1748-5827.2002.tb00066.x","article-title":"Canine neoplasia in the UK: estimates of incidence rates from a population of insured dogs","volume":"43","author":"Dobson","year":"2002"},{"key":"ref22","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1136\/vr.130.8.157","article-title":"Sudden acquired retinal degeneration (\u2018silent retina syndrome\u2019) in two dogs","volume":"130","author":"O'Toole","year":"1992"},{"key":"ref23","series-title":"Brain Res Cogn Brain Res","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S0926-6410(97)00006-2","article-title":"Blind rats are not profoundly impaired in the reference memory Morris water maze and cannot be clearly discriminated from rats with cognitive deficits in the cued platform task","volume":"5","author":"Lindner","year":"1997"},{"key":"ref24","series-title":"Vet Ther","first-page":"247","article-title":"Brain aging in dogs: parallels with human brain aging and Alzheimer's disease","volume":"2","author":"Head","year":"2001"},{"key":"ref25","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cvsm.2004.12.008","article-title":"Behavior problems in geriatric pets","volume":"35","author":"Landsberg","year":"2005"}],"container-title":["Journal of the American Veterinary Medical 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