{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:40:26Z","timestamp":1768545626207,"version":"3.49.0"},"reference-count":37,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2013,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare the perioperative analgesic effect between methadone and butorphanol in cats.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized controlled clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201422 healthy female domestic cats.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Cats admitted for ovariohysterectomy were allocated to a butorphanol group (n = 10) or methadone group (12) and premedicated with butorphanol (0.4 mg\/kg [0.18 mg\/lb], SC) or methadone (0.6 mg\/kg [0.27 mg\/lb], SC), respectively, in combination with acepromazine (0.02 mg\/kg [0.01 mg\/lb], SC). Anesthesia was induced with propofol (IV) and maintained with isoflurane in oxygen. A multidimensional composite scale was used to conduct pain assessments prior to premedication and 5, 20, 60, 120, 180, 240, 300, and 360 minutes after extubation or until rescue analgesia was given. Groups were compared to evaluate isoflurane requirement, propofol requirement, pain scores, and requirement for rescue analgesia.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014Propofol and isoflurane requirements and preoperative pain scores were not different between groups. During recovery, dysphoria prevented pain evaluation at 5 minutes. Pain scores at 20 minutes were significantly lower in the methadone group, and 6 of 10 cats in the butorphanol group received rescue analgesia, making subsequent pain score comparisons inapplicable. After 6 hours, only 3 of 12 cats in the methadone group had received rescue analgesia.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014In the present study, methadone appeared to be a better postoperative analgesic than butorphanol and provided effective analgesia for 6 hours following ovariohysterectomy in most cats. 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antinociception","volume":"274","author":"Codd","year":"1995"},{"key":"ref4","series-title":"J Pharmacol Exp Ther","first-page":"366","article-title":"Blockade of rat alpha-3beta4 nicotinic receptor function by methadone, its metabolites, and structural analogs","volume":"299","author":"Xiao","year":"2001"},{"key":"ref5","series-title":"Pharmacogenetics","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1097\/00008571-200006000-00009","article-title":"Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms","volume":"10","author":"Court","year":"2000"},{"key":"ref6","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1467-2987.2004.00148.x","article-title":"Comparison of perioperative racemic methadone, levo-methadone and dextromoramide in cats using indicators of post-operative pain","volume":"31","author":"Rohrer Bley","year":"2004"},{"key":"ref7","series-title":"J Vet Pharmacol Ther","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1111\/j.1365-2885.2006.00800.x","article-title":"Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats","volume":"29","author":"Steagall","year":"2006"},{"key":"ref8","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"764","DOI":"10.2460\/ajvr.72.6.764","article-title":"Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats","volume":"72","author":"Ferreira","year":"2011"},{"key":"ref9","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1111\/j.1467-2995.2012.00736.x","article-title":"Methadone in combination with acepromazine as premedication prior to neutering in the cat","volume":"40","author":"Bortolami","year":"2013"},{"key":"ref10","series-title":"Drugs","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2165\/00003495-199141030-00002","article-title":"Opioid agonist-antagonist drugs in acute and chronic pain states","volume":"41","author":"Hoskin","year":"1991"},{"key":"ref11","series-title":"Vet Med","first-page":"346","article-title":"Is butorphanol analgesic in dogs and cats?","volume":"94","author":"Wagner","year":"1999"},{"key":"ref12","series-title":"J Am Anim Hosp Assoc","first-page":"438","article-title":"Analgesia and behavioral effects of butorphanol, nalbuphine, and pentazocine in the cat","volume":"23","author":"Sawyer","year":"1987"},{"key":"ref13","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.2460\/ajvr.2004.65.1085","article-title":"Use of thermal threshold response to evaluate the antinociceptive effects of butorphanol in cats","volume":"65","author":"Lascelles","year":"2004"},{"key":"ref14","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.2460\/ajvr.69.12.1548","article-title":"Pharmacokinetics of butorphanol in cats after intramuscular and buccal transmucosal administration","volume":"69","author":"Wells","year":"2008"},{"key":"ref15","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1136\/vr.153.15.462","article-title":"Changes in thermal threshold response in eight cats after administration of buprenorphine, butorphanol and morphine","volume":"153","author":"Robertson","year":"2003"},{"key":"ref16","series-title":"Lumb & Jones' veterinary anesthesia and analgesia","first-page":"241","article-title":"Opioids, nonsteroidal anti-inflammatories, and analgesic adjuvants","author":"Lamont","year":"2007"},{"key":"ref17","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2460\/ajvr.72.2.174","article-title":"Refinement and initial validation of a multidimensional composite scale for use in assessing acute postoperative pain in cats","volume":"72","author":"Brondani","year":"2011"},{"key":"ref18","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1136\/vr.143.7.185","article-title":"Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat","volume":"143","author":"Slingsby","year":"1998"},{"key":"ref19","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1111\/j.1748-5827.1988.tb02290.x","article-title":"Propofol anaesthesia in cats","volume":"29","author":"Brearley","year":"1988"},{"key":"ref20","series-title":"Vet Clin North Am Small","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/S0195-5616(99)50059-4","article-title":"Propofol anesthesia","volume":"29","author":"Short","year":"1999"},{"key":"ref21","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1748-5827.2001.tb01995.x","article-title":"Effect of propofol at two injection rates or thiopentone on post-intubation apnoea in the dog","volume":"42","author":"Murison","year":"2001"},{"key":"ref22","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1093\/bja\/73.5.692","article-title":"Optimum rate of administration of propofol for induction of anaesthesia in rats","volume":"73","author":"Larsson","year":"1994"},{"key":"ref23","series-title":"J Am Vet Med Assoc","first-page":"1099","article-title":"Minimal alveolar concentrations for halothane, enflurane, and isoflurane in the cat","volume":"182","author":"Drummond","year":"1983"},{"key":"ref24","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1111\/j.1939-1676.2004.tb00159.x","article-title":"Antinociceptive effects of hydromorphone, butorphanol, or the combination in cats","volume":"18","author":"Lascelles","year":"2004"},{"key":"ref25","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.2460\/ajvr.2002.63.1198","article-title":"Effects of morphine, butorphanol, buprenorphine, and U50488H on the minimum alveolar concentration of isoflurane in cats","volume":"63","author":"Ilkiw","year":"2002"},{"key":"ref26","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.2460\/ajvr.71.11.1270","article-title":"Effects of perzinfotel, butorphanol tartrate, and a butorphanol-perzinfotel combination on the minimum alveolar concentration of isoflurane in cats","volume":"71","author":"Zwijnenberg","year":"2010"},{"key":"ref27","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/j.1748-5827.2011.01085.x","article-title":"A comparison of the sedative and analgesic properties of pethidine (meperidine) and butorphanol in dogs","volume":"52","author":"Vettorato","year":"2011"},{"key":"ref28","series-title":"Neurosci Lett","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/0304-3940(88)90244-3","article-title":"Sympathetic stimulating effects of sufentanil in the cat are mediated centrally","volume":"91","author":"Gaumann","year":"1988"},{"key":"ref29","series-title":"Am J Vet Res","first-page":"1267","article-title":"Cardiovascular effects of equipotent isoflurane and alfentanil\/isoflurane minimum alveolar concentration multiple in cats","volume":"58","author":"Pascoe","year":"1997"},{"key":"ref30","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1097\/00000542-197101000-00017","article-title":"On the language of pain","volume":"34","author":"Melzack","year":"1971"},{"key":"ref31","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/vr.162.13.403","article-title":"Application of a modified form of the Glasgow pain scale in a veterinary teaching centre in the Netherlands","volume":"162","author":"Murrell","year":"2008"},{"key":"ref32","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.jfms.2008.10.002","article-title":"Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy","volume":"11","author":"Brondani","year":"2009"},{"key":"ref33","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1111\/j.1748-5827.1993.tb02588.x","article-title":"Assessment of methadone as an anaesthetic premedicant in cats","volume":"34","author":"Dobromylskyj","year":"1993"},{"key":"ref34","series-title":"BSAVA manual of small animal anaesthesia and analgesia","first-page":"89","article-title":"Pain management: systemic analgesics","author":"Kerr","year":"1999"},{"key":"ref35","series-title":"J Am Vet Med Assoc","first-page":"61","article-title":"Comparison of three methods used for assessment of pain in dogs","volume":"212","author":"Holton","year":"1998"},{"key":"ref36"},{"key":"ref37"}],"container-title":["Journal of the American Veterinary Medical 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