{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:50:53Z","timestamp":1762375853347,"version":"3.38.0"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2014,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Case Description<\/jats:bold>\u2014A 4-year-old castrated male domestic ferret (<jats:italic>Mustela putorius furo<\/jats:italic>) was examined because of a 3-week history of intermittent seizures, signs of depression, hypocalcemia, and hyperphosphatemia.<\/jats:p>\n<jats:p><jats:bold>Clinical Findings<\/jats:bold>\u2014Plasma biochemical analysis confirmed hyperphosphatemia (17.7 mg\/dL) and low concentrations of total (4.3 mg\/dL) and ionized (0.49 mmol\/L) calcium. Serum parathyroid hormone concentration (2.30 pmol\/L) was low or in the low part of the reference interval.<\/jats:p>\n<jats:p><jats:bold>Treatment and Outcome<\/jats:bold>\u2014Calcium gluconate was administered (2.0 mg\/kg\/h [0.9 mg\/lb\/h], IV), followed by a transition to administration of calcium carbonate (53 mg\/kg [24.1 mg\/lb], PO, q 12 h) and dihydrotachysterol (0.02 mg\/kg\/d [0.009 mg\/lb\/d], PO). Attitude of the ferret improved and seizures ceased as blood calcium concentrations increased. The ferret was reexamined because of seizures approximately 1 year after oral maintenance administration of dihydrotachysterol and calcium was initiated. The ferret responded well to emergency and long-term treatment but then was lost to follow-up monitoring. The ferret died approximately 2 years after the initial evaluation and treatment. Hypertrophic cardiomyopathy was diagnosed during necropsy, but the parathyroid glands could not be identified.<\/jats:p>\n<jats:p><jats:bold>Clinical Relevance<\/jats:bold>\u2014To the authors\u2019 knowledge, primary hypoparathyroidism has not previously been reported in a ferret. The condition should be considered for ferrets with hypocalcemia and hyperphosphatemia without azotemia. Treatment with dihydrotachysterol and oral supplementation of calcium appeared to be a viable option for long-term management.<\/jats:p>","DOI":"10.2460\/javma.245.4.419","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T13:22:12Z","timestamp":1406726532000},"page":"419-424","source":"Crossref","is-referenced-by-count":8,"title":["Suspected primary hypoparathyroidism in a domestic ferret (Mustela putorius furo)"],"prefix":"10.2460","volume":"245","author":[{"given":"Ricardo E.","family":"de Matos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren J.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon R.","family":"Starkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James K.","family":"Morrisey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Ferrets, rabbits, and rodents: clinical medicine and surgery","article-title":"Basic approach to veterinary care","author":"Quesenberry","year":"2012"},{"key":"ref2","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.2460\/javma.2003.222.1093","article-title":"Suspected pseudohypoparathyroidism in a domestic ferret","volume":"222","author":"Wilson","year":"2003"},{"key":"ref3","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1939-1676.1988.tb01971.x","article-title":"Primary hypoparathyroidism in the dog: report of 15 cases and review of 13 previously reported cases","volume":"2","author":"Bruyette","year":"1988"},{"key":"ref4","series-title":"Textbook of veterinary internal medicine","article-title":"Disorders of the parathyroid glands","author":"Feldman","year":"2010"},{"key":"ref5","series-title":"Kirk's current veterinary therapy XIII. 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