{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:49:19Z","timestamp":1763747359200,"version":"3.38.0"},"reference-count":9,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2015,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To compare anamnestic antibody responses of dogs and cats with current versus out-of-date vaccination status.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Cross-sectional study.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201474 dogs and 33 cats.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Serum samples were obtained from dogs and cats that had been exposed to rabies and brought to a veterinarian for proactive serologic monitoring or that had been brought to a veterinarian for booster rabies vaccination. Blood samples were collected on the day of initial evaluation (day 0) and then again 5 to 15 days later. On day 0, a rabies vaccine was administered according to label recommendations. Paired serum samples were analyzed for antirabies antibodies by means of a rapid fluorescent focus inhibition test.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014All animals had an antirabies antibody titer \u2265 0.5 IU\/mL 5 to 15 days after booster vaccination. Dogs with an out-of-date vaccination status had a higher median increase in titer, higher median fold increase in titer, and higher median titer following booster vaccination, compared with dogs with current vaccination status. Most (26\/33) cats, regardless of rabies vaccination status, had a titer \u2265 12 IU\/mL 5 to 15 days after booster vaccination.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results indicated that dogs with out-of-date vaccination status were not inferior in their antibody response following booster rabies vaccination, compared with dogs with current vaccination status. Findings supported immediate booster vaccination followed by observation for 45 days of dogs and cats with an out-of-date vaccination status that are exposed to rabies, as is the current practice for dogs and cats with current vaccination status.<\/jats:p>","DOI":"10.2460\/javma.246.2.205","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T15:14:07Z","timestamp":1420211647000},"page":"205-211","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of anamnestic responses to rabies vaccination in dogs and cats with current and out-of-date vaccination status"],"prefix":"10.2460","volume":"246","author":[{"given":"Michael C.","family":"Moore","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolan D.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher I.","family":"Vahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathleen A.","family":"Hanlon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Mosier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2460\/javma.239.5.609","article-title":"Compendium of animal rabies prevention and control, 2011","volume":"239","author":"Brown","year":"2011"},{"series-title":"States consider controlling rabies vaccination intervals (2011)","author":"Lau","key":"ref2"},{"key":"ref3","series-title":"Bull World Health Organ","first-page":"535","article-title":"A rapid reproducible test for determining rabies neutralizing antibody","volume":"48","author":"Smith","year":"1973"},{"key":"ref4","series-title":"OIE terrestrial manual","first-page":"1","article-title":"Chapter 2.1.13. Rabies","year":"2013"},{"key":"ref5","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1136\/vr.154.14.423","article-title":"Factors affecting the serological response of dogs and cats to rabies vaccination","volume":"154","author":"Mansfield","year":"2004"},{"key":"ref6","series-title":"Stat Med","doi-asserted-by":"publisher","first-page":"5392","DOI":"10.1002\/sim.3367","article-title":"Non-inferiority hypotheses and choice of non-inferiority margin","volume":"27","author":"Ng","year":"2008"},{"key":"ref7","series-title":"Rev Sci Tech","doi-asserted-by":"publisher","first-page":"735","DOI":"10.20506\/rst.11.3.622","article-title":"Practical significance of rabies antibodies in cats and dogs","volume":"11","author":"Aubert","year":"1992"},{"key":"ref8","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.1128\/JVI.72.5.3711-3719.1998","article-title":"Collaboration of antibody and inflammation in clearance of rabies virus from the central nervous system","volume":"72","author":"Hooper","year":"1998"},{"key":"ref9","series-title":"J Comp Pathol","doi-asserted-by":"publisher","first-page":"S60","DOI":"10.1016\/j.jcpa.2009.10.011","article-title":"Ageing, immunosenescence and inflammageing in the dog and cat","volume":"142","author":"Day","year":"2010"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/246\/2\/javma.246.2.205.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/246\/2\/javma.246.2.205.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/246\/2\/javma.246.2.205.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:45:02Z","timestamp":1741347902000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/246\/2\/javma.246.2.205.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,15]]},"references-count":9,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.246.2.205","relation":{},"ISSN":["0003-1488"],"issn-type":[{"type":"print","value":"0003-1488"}],"subject":[],"published":{"date-parts":[[2015,1,15]]}}}