{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:19:14Z","timestamp":1784830754403,"version":"3.55.0"},"reference-count":39,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2015,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To critically evaluate plasma fibrinogen concentration as a diagnostic indicator of inflammation in red-eared sliders (<jats:italic>Trachemys scripta elegans<\/jats:italic>).<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Prospective induced-disease model and prospective cross-sectional study.<\/jats:p>\n<jats:p><jats:bold>Sample<\/jats:bold>\u2014Plasma samples from 12 purpose-bred red-eared sliders and 153 farm-raised red-eared sliders.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014A modification of the Jacobsson method was developed to measure fibrinogen concentration in platelet-poor plasma from red-eared sliders. Purpose-bred turtles had been inoculated with a ranavirus (n = 4) or sterile PBS solution (8) as part of another study. Farm-raised red-eared sliders were categorized as healthy (n = 138) or overtly ill (15) on the basis of physical examination findings at the time of blood sample collection. Samples from 124 of the 138 healthy red-eared sliders were used to establish a fibrinogen concentration reference interval as measured by the modified Jacobsson method. Fibrinogen concentrations in ranavirus-infected and physically ill turtles were compared with those of healthy turtles to determine whether fibrinogen concentration would be a useful diagnostic indicator of inflammation in red-eared sliders.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014The modified Jacobsson method was reliably used to measure fibrinogen concentration. The fibrinogen concentration reference interval from healthy reproductively active female red-eared sliders was right skewed. Fibrinogen concentration did not differ significantly between healthy red-eared sliders and ranavirus-infected or overtly ill red-eared sliders.<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014A reference interval for red-eared slider plasma fibrinogen concentration was established and partitioned by sex to account for considerable right skewing observed for females. Fibrinogen concentration was not a useful indicator of inflammation in red-eared sliders with ranavirus infection or other overt illnesses.<\/jats:p>","DOI":"10.2460\/javma.246.2.245","type":"journal-article","created":{"date-parts":[[2015,1,2]],"date-time":"2015-01-02T15:14:07Z","timestamp":1420211647000},"page":"245-253","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of plasma fibrinogen concentration as a diagnostic indicator of inflammation in red-eared sliders (Trachemys scripta elegans)"],"prefix":"10.2460","volume":"246","author":[{"given":"A Russell","family":"Moore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Allender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy 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