{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:20:37Z","timestamp":1775604037402,"version":"3.50.1"},"reference-count":9,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2015,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To describe the clinical signs, diagnostic findings, surgical management, and outcome in dogs with splenic liposarcoma.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201413 client-owned dogs with splenic liposarcoma.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Medical and pathology records of dogs with a histopathologic diagnosis of splenic liposarcoma from 2002 to 2012 were reviewed for the following data: clinical signs, CBC, biochemical profile, thoracic and abdominal imaging, surgical management, histologic grade, and outcome (local recurrence, distant metastasis, and survival time). Telephone interviews were conducted with referring veterinarians.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u2014The median survival time (MST) was 623 days (range, 1 to 1,283 days). In 5 dogs that died of splenic liposarcoma, survival times ranged from 42 to 369 days. Metastasis at the time of surgery was a negative prognostic indicator: the MST was 45 days for dogs with metastasis and 767 days for dogs without metastasis. Dogs with grade 1 splenic liposarcoma had a significantly greater MST (1,009 days), compared with dogs with grade 2 or 3 splenic liposarcoma (MST, 206 and 74 days, respectively).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Results confirmed that splenic liposarcoma is a rare differential diagnosis in dogs with a splenic mass. Survival time was influenced by preoperative clinical stage and histologic grade.<\/jats:p>","DOI":"10.2460\/javma.247.12.1404","type":"journal-article","created":{"date-parts":[[2015,12,7]],"date-time":"2015-12-07T18:56:13Z","timestamp":1449514573000},"page":"1404-1407","source":"Crossref","is-referenced-by-count":20,"title":["Splenic liposarcoma in dogs: 13 cases (2002\u20132012)"],"prefix":"10.2460","volume":"247","author":[{"given":"Krista L. A.","family":"Gower","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T. N.","family":"Culp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Withrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Small animal clinical oncology","first-page":"359","author":"Withrow","year":"2013"},{"key":"ref2","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"887","DOI":"10.2460\/javma.2004.224.887","article-title":"Liposarcomas in dogs: 56 cases (1989\u20132000)","volume":"224","author":"Baez","year":"2004"},{"key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"784","article-title":"Nonangiogenic and nonlymphomatous sarcomas of the canine spleen: 57 cases (1975\u20131987)","volume":"195","author":"Weinstein","year":"1989"},{"key":"ref4","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1177\/030098589403100105","article-title":"Primary mesenchyal (nonangiomatous\/nonlymphomatous) neoplasms occurring in the canine spleen: anatomic classification, immunohistochemistry, and mitotic activity correlated with patient survival","volume":"31","author":"Spangler","year":"1994"},{"key":"ref5","series-title":"Compend Contin Educ Vet","first-page":"35","article-title":"Clinical approach to splenomegaly in dogs and cats","volume":"18","author":"Neer","year":"1996"},{"key":"ref6","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1939-1676.1997.tb00085.x","article-title":"Pathologic factors affecting postsplenectomy survival in dogs","volume":"11","author":"Spangler","year":"1997"},{"key":"ref7","series-title":"J Am Vet Med Assoc","first-page":"1147","article-title":"Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986\u20131996)","volume":"211","author":"Kuntz","year":"1997"},{"key":"ref8","series-title":"Aust Vet J","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1751-0813.1985.tb06029.x","article-title":"Clinical and haematological features of haemangiosarcoma in dogs","volume":"62","author":"Ng","year":"1985"},{"key":"ref9","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.2460\/javma.2005.227.1442","article-title":"Outcome of dogs with high-grade soft tissue sarcomas treated with and without adjuvant doxorubicin chemotherapy: 39 cases (1996\u20132004)","volume":"227","author":"Selting","year":"2005"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/247\/12\/javma.247.12.1404.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/247\/12\/javma.247.12.1404.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/247\/12\/javma.247.12.1404.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:45:50Z","timestamp":1741347950000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/247\/12\/javma.247.12.1404.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,15]]},"references-count":9,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.2460\/javma.247.12.1404","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12,15]]}}}