{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:53:35Z","timestamp":1770220415650,"version":"3.49.0"},"reference-count":51,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2015,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>Objective<\/jats:bold>\u2014To evaluate the effect of nutrition on recurrent clinical signs of lower urinary tract (LUT) disease in cats with idiopathic cystitis.<\/jats:p>\n<jats:p><jats:bold>Design<\/jats:bold>\u2014Randomized, controlled, masked clinical trial.<\/jats:p>\n<jats:p><jats:bold>Animals<\/jats:bold>\u201431 cats with acute nonobstructive idiopathic cystitis.<\/jats:p>\n<jats:p><jats:bold>Procedures<\/jats:bold>\u2014Cats were assigned to receive 1 of 2 foods (a cystitis prevention or control food) that differed in mineral (calcium, phosphorous, and magnesium), antioxidant, and fatty acid profiles. Owners documented LUT signs daily for up to 1 year. The primary endpoint was the number of recurrent episodes in which a cat had multiple (\u2265 2 concurrent) LUT signs within a day (defined as multiple-sign day). Consecutive days in which a cat had multiple LUT signs were considered as a single episode.<\/jats:p>\n<jats:p><jats:bold>Results<\/jats:bold>\u20144 cats fed prevention food and 2 cats fed control food were excluded from analysis because of noncompliance, gastrointestinal signs, food refusal, or owner voluntary withdrawal. The proportion of cats fed prevention food that had \u2265 1 recurrent episode of multiple-sign days (4\/11) was not significantly lower than that of cats fed control food (9\/14). However, cats fed prevention food had significantly lower mean incidence rates for recurrent episodes of multiple-sign days (0.7 episodes\/1,000 cat-days) and episodes of hematuria (0.3 episodes\/1,000 cat-days), dysuria (0.2 episodes\/1,000 cat-days), and stranguria (0.2 episodes\/1,000 cat-days) as single LUT signs, compared with cats fed control food (5.4, 3.4, 3.1, and 3.8 episodes\/1,000 cat-days, respectively). Significantly fewer cats fed prevention food required analgesics (4\/11), compared with cats fed control food (12\/14).<\/jats:p>\n<jats:p><jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Foods with differing nutritional profiles appeared to impact mean incidence rates of recurrent feline idiopathic cystitis-associated signs.<\/jats:p>","DOI":"10.2460\/javma.247.5.508","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T13:27:36Z","timestamp":1440163656000},"page":"508-517","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of foods with differing nutritional profiles for long-term management of acute nonobstructive idiopathic cystitis in cats"],"prefix":"10.2460","volume":"247","author":[{"given":"John M.","family":"Kruger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jody 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disease","volume":"199","author":"Kruger","year":"1991"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"46","article-title":"Clinical evaluation of cats with nonobstructive urinary tract diseases","volume":"210","author":"Buffington","year":"1997"},{"key":"ref3","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.jfms.2011.08.001","article-title":"Risk factors and clinical presentation of cats with feline idiopathic cystitis","volume":"13","author":"Defauw","year":"2011"},{"key":"ref4","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1748-5827.2005.tb00288.x","article-title":"Evaluation of clinical signs and causes of lower urinary tract disease in European cats","volume":"46","author":"Gerber","year":"2005"},{"key":"ref5","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jfms.2007.06.007","article-title":"Guarded long-term prognosis in male cats with urethral obstruction","volume":"10","author":"Gerber","year":"2008"},{"key":"ref6","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.2460\/javma.2001.218.1429","article-title":"Epidemiologic study of risk factors for lower urinary tract diseases in cats","volume":"218","author":"Lekcharoensuk","year":"2001"},{"key":"ref7","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.jfms.2010.12.012","article-title":"Causes of lower urinary tract disease in Norwegian cats","volume":"13","author":"S\u00e6vik","year":"2011"},{"key":"ref8","series-title":"Current veterinary therapy XIV","first-page":"944","article-title":"Managing feline idiopathic cystitis","author":"Kruger","year":"2009"},{"key":"ref9","series-title":"Textbook of veterinary internal medicine","first-page":"2069","article-title":"Lower urinary tract disorders in cats","author":"Westropp","year":"Elsevier Saunders"},{"key":"ref10","series-title":"J Am Anim Hosp Assoc","first-page":"387","article-title":"Feline urologic syndrome: further investigation into therapy","volume":"18","author":"Barsanti","year":"1982"},{"key":"ref11","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jfms.2003.09.007","article-title":"Oral glucosamine and the management of feline idiopathic cystitis","volume":"6","author":"Gunn-Moore","year":"2004"},{"key":"ref12","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"749","DOI":"10.2460\/javma.2003.222.749","article-title":"Randomized controlled trial of the efficacy of short-term-amitriptyline administration for treatment of acute, nonobstructive, idiopathic lower urinary tract disease in cats","volume":"222","author":"Kruger","year":"2003"},{"key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"361","article-title":"Clinical evaluation of commercially available urinary acidification diets in the management of idiopathic cystitis in cats","volume":"214","author":"Markwell","year":"1999"},{"key":"ref14","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0195-5616(96)50085-9","article-title":"Prednisolone therapy of idiopathic feline lower urinary tract disease: a double-blind clinical study","volume":"26","author":"Osborne","year":"1996"},{"key":"ref15","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"312","DOI":"10.5326\/15473317-31-4-312","article-title":"Recurrent nonobstructive idiopathic feline lower urinary tract disease: an illustrative case report","volume":"31","author":"Kruger","year":"1995"},{"key":"ref16","series-title":"Feline lower urinary tract disease: the Minnesota experience","first-page":"338","author":"Osborne","year":"1997"},{"key":"ref17","series-title":"J Vet Behav","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jveb.2007.02.002","article-title":"Effect of alpha-casozepine (Zylkene) on anxiety in cats","volume":"2","author":"Beata","year":"2007"},{"key":"ref18","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"722","DOI":"10.2460\/javma.228.5.722","article-title":"Risk factors associated with clinical signs of lower urinary tract disease in indoor-housed cats","volume":"228","author":"Buffington","year":"2006"},{"key":"ref19","series-title":"Small animal clinical nutrition","first-page":"927","article-title":"Feline lower urinary tract diseases","author":"Forrester","year":"Mark Morris Institute"},{"key":"ref20","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1748-5827.1991.tb00935.x","article-title":"Perineal urethrostomy versus dietary management in prevention of recurrent lower urinary tract disease","volume":"32","author":"Osborne","year":"1991"},{"key":"ref21","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0195-5616(96)50205-6","article-title":"Feline urethral plugs: etiology and pathogenesis","volume":"26","author":"Osborne","year":"1996"},{"key":"ref22","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.2460\/javma.243.8.1147","article-title":"Efficacy of two commercially available, low-magnesium, urine-acidifying dry foods for the dissolution of struvite uroliths in cats","volume":"243","author":"Lulich","year":"2013"},{"key":"ref23","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/j.juro.2011.03.064","article-title":"AUA guideline for the diagnosis and treatment of interstitial cystitis\/bladder pain syndrome","volume":"185","author":"Hanno","year":"2011"},{"key":"ref24","series-title":"Fundamentals of clinical trials","first-page":"51","article-title":"The randomization process","author":"Freidman","year":"Mosby-Year Book"},{"key":"ref25","series-title":"Small animal clinical nutrition","first-page":"373","article-title":"Feeding young adult cats: before middle age","author":"Gross","year":"Mark Morris Institute"},{"key":"ref26","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.jfms.2006.02.002","article-title":"Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis","volume":"8","author":"Buffington","year":"2006"},{"key":"ref27","series-title":"Behavioral management of cats with idiopathic cystitis","author":"Neilson"},{"key":"ref28","series-title":"Appl Anim Behav Sci","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.applanim.2012.10.014","article-title":"Effects of stressors on the behavior and physiology of domestic cats","volume":"143","author":"Stella","year":"2013"},{"key":"ref29","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2460\/javma.238.1.67","article-title":"Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis","volume":"238","author":"Stella","year":"2011"},{"key":"ref30","series-title":"Generalized linear mixed models: modern concepts, methods and applications","author":"Stroup","year":"2013"},{"key":"ref31","series-title":"Biometrika","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/biomet\/76.2.297","article-title":"Regression and time series model selection in small samples","volume":"76","author":"Hurvich","year":"1989"},{"key":"ref32","series-title":"Veterinary epidemiology","first-page":"46","article-title":"Describing disease occurrence","author":"Thrusfield","year":"Blackwell Publishing"},{"key":"ref33","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jfms.2008.09.003","article-title":"Use of pentosan polysulphate in cats with idiopathic, nonobstructive lower urinary tract disease: a double-blind, randomized, placebo-controlled trial","volume":"11","author":"Wallius","year":"2009"},{"key":"ref34","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1056\/NEJM197809282991304","article-title":"The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 \u201cnegative\u201d trials","volume":"299","author":"Freiman","year":"1978"},{"key":"ref35","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.2460\/javma.239.11.1441","article-title":"Therapeutic use of fish oils in companion animals","volume":"239","author":"Bauer","year":"2011"},{"key":"ref36","series-title":"Am J Clin Nutr","doi-asserted-by":"publisher","first-page":"1505S","DOI":"10.1093\/ajcn\/83.6.1505S","article-title":"n-3 polyunsaturated fatty acids, inflammation, and inflammatory disease","volume":"83","author":"Calder","year":"2006"},{"key":"ref37","series-title":"Annu Rev Nutr","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev.nutr.24.012003.132446","article-title":"Vitamin E, oxidative stress, and inflammation","volume":"25","author":"Singh","year":"2005"},{"key":"ref38","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1748-5827.2004.tb00216.x","article-title":"A study of environmental and behavioral factors that may be associated with idiopathic cystitis","volume":"45","author":"Cameron","year":"2004"},{"key":"ref39","series-title":"J Am Vet Med Assoc","first-page":"103","article-title":"Intermittent alkaline urine in a cat fed an acidifying diet","volume":"209","author":"Buffington","year":"1996"},{"key":"ref40","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/j.1748-5827.1994.tb03823.x","article-title":"Dietary treatment of progressive feline struvite crystalluria","volume":"35","author":"Gevaert","year":"1994"},{"key":"ref41","series-title":"J Am Vet Med Assoc","first-page":"153","article-title":"The relationship of struvite crystals to urethral obstruction","volume":"154","author":"Rich","year":"1969"},{"key":"ref42","series-title":"Feline struvite urolithiasis: effect of diet","first-page":"60","author":"Buffington","year":"1988"},{"key":"ref43","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1748-5827.1992.tb01135.x","article-title":"Effect of food intake on urine pH in cats","volume":"33","author":"Finke","year":"1992"},{"key":"ref44","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1136\/vr.121.11.245","article-title":"Feline struvite urolithiasis: fasting reduced the effectiveness of a urinary acidifier (ammonium chloride) and increased the intake of a low magnesium diet","volume":"121","author":"Tarttelin","year":"1987"},{"key":"ref45","series-title":"J Am Vet Med Assoc","first-page":"433","article-title":"Evaluation of ammonium chloride as a urinary acidifier in the cat","volume":"184","author":"Taton","year":"1984"},{"key":"ref46","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0195-5616(99)50004-1","article-title":"Methods for evaluating treatment or uroliths","volume":"29","author":"Bartges","year":"1999"},{"key":"ref47","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.2460\/ajvr.74.10.1347","article-title":"Influence of acidifying of alkalinizing diets on bone mineral density and urine relative supersaturation with calcium oxalate and struvite in healthy cats","volume":"74","author":"Bartges","year":"2013"},{"key":"ref48","series-title":"Scanning Microsc","first-page":"597","article-title":"Heterogeneous nucleation of calcium oxalate crystals in mammalian urine","volume":"9","author":"Khan","year":"1995"},{"key":"ref49","series-title":"J Am Vet Med Assoc","first-page":"1429","article-title":"Evaluation of factors associated with development of calcium oxalate urolithiasis in cats","volume":"207","author":"Kirk","year":"1995"},{"key":"ref50","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.2460\/javma.2001.219.1228","article-title":"Association between dietary factors and calcium oxalate and magnesium ammonium phosphate urolithiasis in cats","volume":"219","author":"Lekcharoensuk","year":"2001"},{"key":"ref51","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"447","DOI":"10.2460\/ajvr.73.3.447","article-title":"Effects of urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis","volume":"73","author":"Lulich","year":"2012"}],"container-title":["Journal of the American Veterinary Medical 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