{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:54:35Z","timestamp":1787025275489,"version":"build-2736575974"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2016,6,1]]},"abstract":"Abstract<\/jats:title>\n \n OBJECTIVE<\/jats:bold>\n To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine.\n <\/jats:p>\n \n DESIGN<\/jats:bold>\n Randomized controlled trial.\n <\/jats:p>\n \n ANIMALS<\/jats:bold>\n 66 healthy female domestic shorthair cats.\n <\/jats:p>\n \n PROCEDURES<\/jats:bold>\n Cats were randomly assigned to receive maropitant (1 mg\/kg [0.45 mg\/lb], SC; maropitant group; n = 32) or saline (0.9% NaCl) solution (0.1 mL\/kg [0.045 mL\/lb], SC; control group; 34) 20 hours before IM administration of dexmedetomidine (20 \u03bcg\/kg [9.1 \u03bcg\/lb]) and morphine (0.1 mg\/kg). Following administration of dexmedetomidine and morphine, the incidences of emesis, retching, and signs of nausea (sialorrhea and lip licking) were compared between the 2 groups. The aversive behavioral response of each cat to injection of maropitant or saline solution was scored on a visual analogue scale by each of 4 observers who were unaware of the treatment administered.\n <\/jats:p>\n \n RESULTS<\/jats:bold>\n Only 1 of 32 cats in the maropitant group vomited, whereas 20 of 34 control cats vomited. The incidences of emesis and retching for the maropitant group were significantly lower than those for the control group. The incidence of signs of nausea did not differ between the 2 groups. Visual analogue scale scores for the maropitant group were significantly higher than those for the control group.\n <\/jats:p>\n \n CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold>\n Results of the present study indicated that administration of maropitant to healthy cats approximately 20 hours prior to administration of dexmedetomidine and morphine significantly decreased the incidence of emesis but did not decrease the incidence of signs of nausea. However, maropitant appeared to cause substantial discomfort when injected SC.\n <\/jats:p>","DOI":"10.2460\/javma.248.11.1257","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T11:17:10Z","timestamp":1463051830000},"page":"1257-1261","source":"Crossref","is-referenced-by-count":26,"title":["Effects of maropitant in cats receiving dexmedetomidine and morphine"],"prefix":"10.2460","volume":"248","author":[{"given":"Manuel","family":"Martin-Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McKenzie M.","family":"Learn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Mastrocco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Campoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn M.","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin D.","family":"Gleed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/j.1467-2995.2011.00619.x","article-title":"A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats","volume":"38","author":"Santos","year":"2011"},{"key":"ref2","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jfms.2008.05.003","article-title":"Antinociceptive and side-effects of hydromorphone after subcutaneous administration in cats","volume":"11","author":"Robertson","year":"2009"},{"key":"ref3","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.jfms.2010.06.008","article-title":"Effects of metoclopramide on emesis in cats sedated with xylazine hydrochloride","volume":"12","author":"Kolahian","year":"2010"},{"key":"ref4","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1467-2995.2012.00788.x","article-title":"Efficacy of maropitant in preventing vomiting in dogs premedicated with hydromorphone","volume":"40","author":"Hay Kraus","year":"2013"},{"key":"ref5","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1111\/jvim.12414","article-title":"Effects of maropitant citrate or acepromazine on the incidence of adverse events associated with hydromorphone premedication in dogs","volume":"28","author":"Claude","year":"2014"},{"key":"ref6","article-title":"Cerenia [package insert]","year":"2012"},{"key":"ref7","series-title":"Anesthetic pharmacology: physiologic principles and clinical practice (a companion to Miller's anesthesia).","first-page":"777","article-title":"Antiemetics","author":"Scholz","year":"2004"},{"key":"ref8","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.2460\/ajvr.2001.62.1218","article-title":"Effects of dexamethasone on emesis in cats sedated with xylazine hydrochloride","volume":"62","author":"Ho","year":"2001"},{"key":"ref9","series-title":"Can Vet J","first-page":"193","article-title":"Antiemetic efficacy of promethazine on xylazine-induced emesis in cats","volume":"53","author":"Kolahian","year":"2012"},{"key":"ref10","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.2460\/javma.245.9.1015","article-title":"Effect of dosing interval on efficacy of maropitant for prevention of hydromorphone-induced vomiting and signs of nausea in dogs","volume":"245","author":"Hay Kraus","year":"2014"},{"key":"ref11","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/vaa.12120","article-title":"Maropitant prevented vomiting but not gastroesophageal reflux in anesthetized dogs premedicated with acepromazine-hydromorphone","volume":"41","author":"Johnson","year":"2014"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/248\/11\/javma.248.11.1257.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/248\/11\/javma.248.11.1257.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/248\/11\/javma.248.11.1257.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T19:39:03Z","timestamp":1696534743000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/248\/11\/javma.248.11.1257.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,1]]},"references-count":11,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.2460\/javma.248.11.1257","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6,1]]}}}