{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:27:22Z","timestamp":1773030442633,"version":"3.50.1"},"reference-count":51,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2016,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate the outcome associated with unilateral nephrectomy in feline kidney donors.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 141 cats.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Medical records of cats that underwent nephrectomy for renal donation were reviewed for information on signalment, date of renal donation, results of blood and urine analyses, infectious disease history, anesthetic protocols, intra- and postoperative complications, and postoperative analgesic protocols. Long-term follow-up data were obtained via client telephone interview and review of referring veterinarian medical records.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> All donors were healthy young adult cats with a median age of 1.5 years (range, 0.8 to 2 years). No cats died or were euthanized during the perioperative period. Intraoperative complications occurred in 2 cats, and postoperative complications occurred in 17. Median time from nephrectomy to hospital discharge was 3.6 days (range, 2 to 8 days). Long-term follow-up information was available for 99 cats, with a median interval between nephrectomy and follow-up of 10 years (range, 0.25 to 15 years). Six cats had a history of urinary tract disease including stable chronic kidney disease (n = 3), acute kidney injury (2), and cystitis (1). Nine cats were dead at follow-up; death was attributed to chronic renal failure in 2 and acute ureteral obstruction in 4.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Feline donor nephrectomy had an acceptably low perioperative morbidity in this series. Most cats (84%) for which follow-up information was available had no associated long-term effects. However, a small subset (7%) developed renal insufficiency or died of urinary tract disease.<\/jats:p>","DOI":"10.2460\/javma.248.3.275","type":"journal-article","created":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T19:02:21Z","timestamp":1453489341000},"page":"275-281","source":"Crossref","is-referenced-by-count":8,"title":["Perioperative morbidity and long-term outcome of unilateral nephrectomy in feline kidney donors: 141 cases (1998\u20132013)"],"prefix":"10.2460","volume":"248","author":[{"given":"Chloe","family":"Wormser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian R.","family":"Aronson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"183","article-title":"Status on renal transplantation in the 1990s","volume":"7","author":"Gregory","year":"1992"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"285","article-title":"Renal transplantation for treatment of end-stage renal failure in cats","volume":"201","author":"Gregory","year":"1992"},{"key":"ref3","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1097\/00000658-198606000-00008","article-title":"Living related kidney donors","volume":"203","author":"Dunn","year":"1986"},{"key":"ref4","series-title":"Transplant Proc","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/S0041-1345(03)00135-0","article-title":"Clinical outcome of living kidney donation","volume":"35","author":"Ciszek","year":"2003"},{"key":"ref5","series-title":"Transplantation","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1097\/00007890-199710270-00007","article-title":"Complications and risks of living donor nephrectomy","volume":"64","author":"Johnson","year":"1997"},{"key":"ref6","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/0140-6736(92)92683-7","article-title":"20 years or more of follow-up of living kidney donors","volume":"340","author":"Najarian","year":"1992"},{"key":"ref7","series-title":"Clin J Am Soc Nephrol","doi-asserted-by":"publisher","first-page":"366","DOI":"10.2215\/CJN.10561011","article-title":"The living kidney donor evaluation: focus on renal issues","volume":"7","author":"Kher","year":"2012"},{"key":"ref8","series-title":"Transplantation","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1097\/00007890-200108150-00015","article-title":"No evidence of accelerated loss of kidney function in living kidney donors: results from a cross-sectional follow-up","volume":"72","author":"Fehrman-Ekholm","year":"2001"},{"key":"ref9","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1056\/NEJMoa0804883","article-title":"Long-term consequences of kidney donation","volume":"360","author":"Ibrahim","year":"2009"},{"key":"ref10","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1001\/jama.2013.285141","article-title":"Risk of end-stage renal disease following live kidney donation","volume":"311","author":"Muzaale","year":"2014"},{"key":"ref11","series-title":"Kidney Int","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1038\/ki.2013.460","article-title":"Long-term risks for kidney donors","volume":"86","author":"Mj\u00f8en","year":"2014"},{"key":"ref12","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1111\/j.1532-950X.2008.00435.x","article-title":"Survival, complications, and analysis of risk factors after renal transplantation in cats","volume":"37","author":"Schmiedt","year":"2008"},{"key":"ref13","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"743","DOI":"10.2460\/javma.228.5.743","article-title":"Renal transplantation in cats with calcium oxalate urolithiasis: 19 cases (1997\u20132004)","volume":"228","author":"Aronson","year":"2006"},{"key":"ref14","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.2460\/ajvr.2003.64.1248","article-title":"Evaluation of erythropoiesis and changes in serum erythropoietin concentration in cats after renal transplantation","volume":"64","author":"Aronson","year":"2003"},{"key":"ref15","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/jvet.2002.30540","article-title":"The prevalence of malignant neoplasia in feline renal-transplant recipients","volume":"31","author":"Wooldridge","year":"2002"},{"key":"ref16","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.2460\/javma.243.11.1580","article-title":"Retroperitoneal fibrosis in feline renal transplant recipients: 29 cases (1998\u20132011)","volume":"243","author":"Wormser","year":"2013"},{"key":"ref17","series-title":"J Am Vet Med Assoc","first-page":"1044","article-title":"Long-term renal and hematologic effects of uninephrectomy in healthy feline kidney donors","volume":"207","author":"Lirtzman","year":"1995"},{"key":"ref18","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1111\/j.1740-8261.2003.tb00522.x","article-title":"Use of computed tomography renal angiography for screening feline renal transplant donors","volume":"44","author":"Bouma","year":"2003"},{"key":"ref19","series-title":"Vet Radiol Ultrasound","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1740-8261.2008.00378.x","article-title":"Characterization of normal feline renal vascular anatomy with dual-phase CT angiography","volume":"49","author":"C\u00e1ceres","year":"2008"},{"key":"ref20","series-title":"Veterinary surgery: small animal","first-page":"2019","article-title":"Renal transplant","author":"Aronson","year":"2012"},{"key":"ref21","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1097\/00000658-200009000-00011","article-title":"Increased rates of donation with laparoscopic donor nephrectomy","volume":"232","author":"Schweitzer","year":"2000"},{"key":"ref22","series-title":"Transplant Proc","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/j.transproceed.2007.04.017","article-title":"Is living kidney donation really safe?","volume":"39","author":"Azar","year":"2007"},{"key":"ref23","series-title":"Transplant Proc","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1016\/j.transproceed.2004.08.016","article-title":"Risks and quality-of-life changes in living kidney donors","volume":"36","author":"Chen","year":"2004"},{"key":"ref24","series-title":"Transplant Proc","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.transproceed.2007.12.010","article-title":"Medical risk analysis of renal transplant donors","volume":"40","author":"Berber","year":"2008"},{"key":"ref25","series-title":"Transplant Rev (Orlando)","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.trre.2008.04.003","article-title":"Responding to offers of altruistic living unrelated kidney donation by group associations: an ethical analysis","volume":"22","author":"Mueller","year":"2008"},{"key":"ref26","series-title":"Exp Clin Transplant","first-page":"485","article-title":"Ethical issues in living donor kidney transplantation","volume":"4","author":"Mazaris","year":"2006"},{"key":"ref27","series-title":"Exp Clin Transplant","first-page":"1","article-title":"Ethical issues in live donor kidney transplant: views of medical and nursing staff","volume":"7","author":"Mazaris","year":"2009"},{"key":"ref28","series-title":"Exp Clin Transplant","first-page":"181","article-title":"Expanding the live kidney donor pool: ethical considerations regarding altruistic donors, paired and pooled programs","volume":"9","author":"Patel","year":"2011"},{"key":"ref29","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/S0140-6736(14)62484-3","article-title":"Living kidney donation: outcomes, ethics, and uncertainty","volume":"385","author":"Reese","year":"2015"},{"key":"ref30","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1172\/JCI78885","article-title":"Longitudinal study of living kidney donor glomerular dynamics after nephrectomy","volume":"125","author":"Lenihan","year":"2015"},{"key":"ref31","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1001\/jama.1966.03100170064019","article-title":"Renal function in 29 healthy adults before and after nephrectomy","volume":"196","author":"Krohn","year":"1966"},{"key":"ref32","series-title":"Am J Physiol Renal Physiol","doi-asserted-by":"publisher","first-page":"F629","DOI":"10.1152\/ajprenal.00329.2005","article-title":"Adaptive hyperfiltration in the aging kidney after contralateral nephrectomy","volume":"291","author":"Saxena","year":"2006"},{"key":"ref33","series-title":"Transplantation","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/01.TP.0000128168.97735.B3","article-title":"Blood pressure and renal function after kidney donation from hypertensive living donors","volume":"78","author":"Textor","year":"2004"},{"key":"ref34","series-title":"Am J Transplant","doi-asserted-by":"publisher","first-page":"2417","DOI":"10.1111\/j.1600-6143.2005.01037.x","article-title":"Long-term consequences of live kidney donation follow-up in 93% of living kidney donors in a single transplant center","volume":"5","author":"Gossmann","year":"2005"},{"key":"ref35","series-title":"Am J Surg","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/S0002-9610(85)80104-5","article-title":"Urinary albumin excretion in renal transplant donors","volume":"149","author":"Chavers","year":"1985"},{"key":"ref36","series-title":"Kidney Int","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/ki.1984.112","article-title":"Hypertension and proteinuria: long-term sequelae of uninephrectomy in humans","volume":"25","author":"Hakim","year":"1984"},{"key":"ref37","series-title":"Kidney Int","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/ki.1986.109","article-title":"Long-term blood pressure and renal function in kidney donors","volume":"29","author":"Talseth","year":"1986"},{"key":"ref38","series-title":"Transplantation","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/TP.0b013e31817ba9e3","article-title":"Cardiovascular disease and hypertension risk in living donors: an analysis of health administrative data in Ontario, Canada","volume":"86","author":"Garg","year":"2008"},{"key":"ref39","series-title":"PLoS Med","doi-asserted-by":"publisher","first-page":"e1000440","DOI":"10.1371\/journal.pmed.1000440","article-title":"Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts","volume":"8","author":"Wills","year":"2011"},{"key":"ref40","series-title":"Am J Transplant","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1111\/j.1600-6143.2007.01975.x","article-title":"2509 living donor nephrectomies, morbidity and mortality, including the UK introduction of laparoscopic donor surgery","volume":"7","author":"Hadjianastassiou","year":"2007"},{"key":"ref41","series-title":"J Urol","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1016\/S0022-5347(05)65502-4","article-title":"Renal outcomes 25 years after donor nephrectomy","volume":"166","author":"Goldfarb","year":"2001"},{"key":"ref42","series-title":"Transplantation","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1097\/01.tp.0000250728.73268.e3","article-title":"Incidence of end-stage renal disease among live kidney donors","volume":"82","author":"Fehrman-Ekholm","year":"2006"},{"key":"ref43","series-title":"Compend Contin Educ Pract Vet","first-page":"127","article-title":"Feline renal failure: questions, answers, questions","volume":"14","author":"Lulich","year":"1992"},{"key":"ref44","series-title":"J Am Vet Med Assoc","first-page":"1150","article-title":"Diagnosis and surgical management of obstructive ureteral calculi in cats: 11 cases (1993\u20131996)","volume":"213","author":"Kyles","year":"1998"},{"key":"ref45","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1939-1676.1998.tb00491.x","article-title":"Renal calculi in dogs and cats: prevalence, mineral type, breed, age, and gender interrelationships (1981\u20131993)","volume":"12","author":"Ling","year":"1998"},{"key":"ref46","series-title":"Vet Clin North Am Small Anim Pract","first-page":"183","article-title":"Analysis of 451,891 canine uroliths, feline uroliths, and feline urethral plugs from 1981 to 2007: perspectives from the Minnesota Urolith Center","volume":"39","author":"Osborne","year":"2008"},{"key":"ref47","series-title":"J Am Vet Med Assoc","first-page":"1429","article-title":"Evaluation of factors associated with development of calcium oxalate urolithiasis in cats","volume":"207","author":"Kirk","year":"1995"},{"key":"ref48","series-title":"Vet Clin North Am Small Anim Pract","first-page":"967","article-title":"Update: management of calcium oxalate uroliths in dogs and cats","volume":"34","author":"Bartges","year":"2004"},{"key":"ref49","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"937","DOI":"10.2460\/javma.2005.226.937","article-title":"Management and outcome of cats with ureteral calculi: 153 cases (1984\u20132002)","volume":"226","author":"Kyles","year":"2005"},{"key":"ref50","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"932","DOI":"10.2460\/javma.2005.226.932","article-title":"Clinical, clinicopathological, radiographic, and ultrasonographic abnormalities in cats with ureteral calculi: 163 cases (1984\u20132002)","volume":"226","author":"Kyles","year":"2005"},{"key":"ref51","series-title":"Acta Urol Belg","first-page":"7","article-title":"Conservative management of ureteric stones","volume":"65","author":"Simon","year":"1997"}],"container-title":["Journal of the American Veterinary Medical 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