{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:17:22Z","timestamp":1789831042124,"version":"4.0.1"},"reference-count":46,"publisher":"American Veterinary Medical Association (AVMA)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To investigate associations between recovery of locomotion and putative prognostic factors in dogs with loss of deep pain perception in the pelvic limbs caused by intervertebral disk herniation (IVDH).<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Prospective cohort study.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 78 client-owned dogs evaluated for IVDH that underwent spinal decompression surgery.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs with complete loss of deep pain perception in the pelvic limbs and tail underwent routine examinations, advanced imaging, and spinal decompression surgery in accordance with standards of practice and owner consent. For each dog, information was prospectively collected on duration of clinical signs prior to onset of paraplegia; delay between onset of paraplegia and initial referral evaluation; date of recovery of locomotion, death, or euthanasia (3-month follow-up period); and whether dogs had received corticosteroid drugs before surgery. Severity of spinal cord compression at the lesion epicenter was measured via CT or MRI.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> 45 of 78 (58%) of dogs recovered the ability to ambulate independently within 3 months after spinal decompression surgery. No evidence of prognostic value was identified for any of the investigated factors; importantly, a greater delay between onset of paraplegia and referral evaluation was not associated with a poorer prognosis.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> In this group of dogs with IVDH, immediacy of surgical treatment had no apparent association with outcome. The prognosis for recovery may instead be strongly influenced by the precise nature of the initiating injury.<\/jats:p>","DOI":"10.2460\/javma.248.4.386","type":"journal-article","created":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T16:24:37Z","timestamp":1454343877000},"page":"386-394","source":"Crossref","is-referenced-by-count":95,"title":["Factors associated with recovery from paraplegia in dogs with loss of pain perception in the pelvic limbs following intervertebral disk herniation"],"prefix":"10.2460","volume":"248","author":[{"given":"Nick D.","family":"Jeffery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary Z.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody J.","family":"Alcott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl H.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Scanlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Granger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Compend Contin Educ Pract Vet","first-page":"E1","article-title":"Canine thoracolumbar intervertebral disk disease: diagnosis, prognosis and treatment","volume":"31","author":"Griffin","year":"2009"},{"key":"ref2","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1111\/jvim.12183","article-title":"Intervertebral disk degeneration in dogs: consequences, diagnosis, treatment, and future directions","volume":"27","author":"Jeffery","year":"2013"},{"key":"ref3","series-title":"Am J Vet Res","first-page":"1687","article-title":"Canine intervertebral disk disease: characterization by age, sex, breed, and anatomic site of involvement","volume":"31","author":"Goggin","year":"1970"},{"key":"ref4","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.2460\/javma.240.11.1300","article-title":"Incidence of intervertebral disk degeneration-related diseases and associated mortality rates in dogs","volume":"240","author":"Bergknut","year":"2012"},{"key":"ref5","series-title":"Vet J","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.tvjl.2012.10.011","article-title":"Intervertebral disc degeneration in the dog. 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