{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:02:27Z","timestamp":1769421747608,"version":"3.49.0"},"reference-count":30,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate outcomes for cats treated with orally administered famciclovir 3 times\/d for clinical signs attributed to naturally occurring feline herpesvirus type 1 (FHV-1) infection and to assess variables related to owner satisfaction with the treatment.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Retrospective case series.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 59 client-owned cats.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Medical records were reviewed to identify cats treated for presumed FHV-1 infection from 2006 through 2013 with \u2265 1 follow-up visit. Signalment, duration of clinical signs, prior treatment, examination findings, diagnostic test results, concurrent treatments, and outcome data were recorded. Owners were asked to complete a survey regarding patient- and treatment-related variables. Data were compared between cats that received low (approx 40 mg\/kg [18 mg\/lb]) and high (approx 90 mg\/kg [41 mg\/lb]) doses of famciclovir, PO, 3 times\/d.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Patient age ranged from 0.03 to 16 years. Conjunctivitis (51\/59 [86%]), keratitis (51 [86%]), blepharitis (19 [32%]), nasal discharge or sneezing (10 [17%]), and dermatitis (4 [7%]) were common findings. Clinical improvement was subjectively graded as marked in 30 (51%) cats, mild in 20 (34%), and nonapparent in 9 (15%). Median time to improvement was significantly shorter, and degree of improvement was significantly greater in the highdose group than in the low-dose group. Adverse effects potentially attributable to famciclovir administration were reported for 10 cats. On the basis of survey responses, most (29\/32 [91%]) owners were satisfied with their cat's treatment.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Famciclovir at the prescribed dosages was associated with improved clinical signs in cats with presumed FHV-1 infection, and few adverse effects were attributed to the treatment. Further studies are needed to assess whether a famciclovir dosage of 90 versus 40 mg\/kg, PO, 3 times\/d would result in increased efficacy and shorter treatment time.<\/jats:p>","DOI":"10.2460\/javma.249.5.526","type":"journal-article","created":{"date-parts":[[2016,8,24]],"date-time":"2016-08-24T14:23:28Z","timestamp":1472048608000},"page":"526-538","source":"Crossref","is-referenced-by-count":48,"title":["Oral administration of famciclovir for treatment of spontaneous ocular, respiratory, or dermatologic disease attributed to feline herpesvirus type 1: 59 cases (2006\u20132013)"],"prefix":"10.2460","volume":"249","author":[{"given":"Sara M.","family":"Thomasy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Shull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Outerbridge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine C.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate S.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann R.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip H.","family":"Kass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Maggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cvsm.2010.07.010","article-title":"Antiviral therapy for feline herpesvirus infections","volume":"40","author":"Maggs","year":"2010"},{"key":"ref2","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jfms.2011.03.010","article-title":"Feline herpesvirus-1: ocular manifestations, diagnosis and treatment options","volume":"13","author":"Gould","year":"2011"},{"key":"ref3","series-title":"Xenobiotica","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3109\/00498259509061867","article-title":"Metabolic and pharmacokinetic studies following oral administration of famciclovir to the rat and dog","volume":"25","author":"Filer","year":"1995"},{"key":"ref4","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"399","DOI":"10.2460\/ajvr.2004.65.399","article-title":"In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1","volume":"65","author":"Maggs","year":"2004"},{"key":"ref5","series-title":"Curr Eye Res","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/02713680490504849","article-title":"Efficacy of antiviral agents in feline herpetic keratitis: results of an in vitro study","volume":"29","author":"Williams","year":"2004"},{"key":"ref6","series-title":"J Virol Methods","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jviromet.2008.05.018","article-title":"Development of a quantitative realtime TaqMan PCR assay for testing the susceptibility of feline herpesvirus-1 to antiviral compounds","volume":"152","author":"Hussein","year":"2008"},{"key":"ref7","series-title":"Antiviral Res","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.antiviral.2007.10.015","article-title":"Penciclovir is a potent inhibitor of feline herpesvirus-1 with susceptibility determined at the level of virus-encoded thymidine kinase","volume":"78","author":"Hussein","year":"2008"},{"key":"ref8","series-title":"Vet Ophthalmol","first-page":"416","article-title":"Assessment of antiviral efficacy against feline herpesvirus and cytotoxicity of famciclovir and its metabolites, and intracellular accumulation of penciclovir","volume":"13","author":"Groth","year":"2010"},{"key":"ref9","series-title":"J Vet Pharmacol Ther","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/j.1365-2885.1996.tb00087.x","article-title":"Pharmacokinetics of acyclovir in the cat","volume":"19","author":"Owens","year":"1996"},{"key":"ref10","series-title":"Am J Vet Res","first-page":"1141","article-title":"Effects of valacyclovir in cats infected with feline herpesvirus 1","volume":"58","author":"Nasisse","year":"1997"},{"key":"ref11","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.2460\/ajvr.68.11.1252","article-title":"Pharmacokinetics and safety of penciclovir following oral administration of famciclovir to cats","volume":"68","author":"Thomasy","year":"2007"},{"key":"ref12","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2460\/ajvr.72.1.85","article-title":"Evaluation of orally administered famciclovir in cats experimentally infected with feline herpesvirus type-1","volume":"72","author":"Thomasy","year":"2011"},{"key":"ref13","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.2460\/ajvr.73.7.1092","article-title":"Pharmacokinetics of penciclovir in healthy cats following oral administration of famciclovir or intravenous infusion of penciclovir","volume":"73","author":"Thomasy","year":"2012"},{"issue":"suppl 1","key":"ref14","series-title":"Antivir Chem Chemother","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1177\/09563202930040S602","article-title":"Pharmacokinetics of famciclovir in man","volume":"4","author":"Pue","year":"1993"},{"key":"ref15","series-title":"Vet Ophthalmol","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1463-5224.2011.00984.x","article-title":"Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study","volume":"15","author":"Thomasy","year":"2012"},{"key":"ref16","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jfms.2008.11.012","article-title":"Treatment of feline herpesvirus-1 associated disease in cats with famciclovir and related drugs","volume":"11","author":"Malik","year":"2009"},{"key":"ref17","series-title":"Mod Vet Pract","first-page":"48","article-title":"The Schirmer tear test\u2014in cats","volume":"51","author":"Veith","year":"1970"},{"key":"ref18","series-title":"Am J Vet Res","first-page":"1917","article-title":"Evaluation of two applanation tonometers in cats","volume":"52","author":"Miller","year":"1991"},{"issue":"suppl 1","key":"ref19","series-title":"Vet Ophthalmol","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/vop.12016","article-title":"Restrictive orbital myofibroblastic sarcoma in a cat-cross-sectional imaging (MRI & CT) appearance, treatment, and outcome","volume":"16","author":"Thomasy","year":"2013"},{"key":"ref20","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1086\/590561","article-title":"Single-day, patient-initiated famciclovir therapy versus 3-day valacyclovir regimen for recurrent genital herpes: a randomized, double-blind, comparative trial","volume":"47","author":"Abudalu","year":"2008"},{"key":"ref21","series-title":"Vet J","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tvjl.2014.11.011","article-title":"Clinical and antiviral effect of a single oral dose of famciclovir administered to cats at intake to a shelter","volume":"203","author":"Litster","year":"2015"},{"key":"ref22","series-title":"J Virol","doi-asserted-by":"publisher","first-page":"9166","DOI":"10.1128\/JVI.72.11.9166-9172.1998","article-title":"Persistence of herpes simplex virus type 1 DNA in chronic conjunctival and eyelid lesions of mice","volume":"72","author":"Maggs","year":"1998"},{"key":"ref23","series-title":"J Clin Diagn Res","first-page":"2904","article-title":"A comparative study to evaluate the efficacy and safety of acyclovir and famciclovir in the management of herpes zoster","volume":"7","author":"Gopal","year":"2013"},{"key":"ref24","series-title":"J Infect","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jinf.2008.06.008","article-title":"Famciclovir substitution for patients with acyclovir-associated renal toxicity","volume":"57","author":"Htwe","year":"2008"},{"key":"ref25","series-title":"Clin Pharmacol Ther","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/clpt.1994.51","article-title":"Pharmacokinetics of famciclovir in subjects with varying degrees of renal impairment","volume":"55","author":"Boike","year":"1994"},{"key":"ref26","series-title":"Antimicrob Agents Chemother","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1128\/AAC.01508-09","article-title":"Single-dose pharmacokinetics of famciclovir in infants and population pharmacokinetic analysis in infants and children","volume":"54","author":"Blumer","year":"2010"},{"key":"ref27","series-title":"Antimicrob Agents Chemother","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1128\/AAC.01054-08","article-title":"Pharmacokinetics and safety of famciclovir in children with herpes simplex or varicella-zoster virus infection","volume":"53","author":"S\u00e1ez-Llorens","year":"2009"},{"key":"ref28","series-title":"J Am Vet Med Assoc","first-page":"502","article-title":"Evaluation of serologic and viral detection methods for diagnosing feline herpesvirus-1 infection in cats with acute respiratory tract or chronic ocular disease","volume":"214","author":"Maggs","year":"1999"},{"key":"ref29","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"643","DOI":"10.2460\/ajvr.68.6.643","article-title":"Prevalence of feline herpesvirus 1, Chlamydophila felis, and Mycoplasma spp DNA in conjunctival cells collected from cats with and without conjunctivitis","volume":"68","author":"Low","year":"2007"},{"key":"ref30","series-title":"Clin Tech Small Anim Pract","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/j.ctsap.2004.12.013","article-title":"Update on pathogenesis, diagnosis, and treatment of feline herpesvirus type 1","volume":"20","author":"Maggs","year":"2005"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/249\/5\/javma.249.5.526.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/249\/5\/javma.249.5.526.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/249\/5\/javma.249.5.526.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:50:31Z","timestamp":1741348231000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/249\/5\/javma.249.5.526.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":30,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.2460\/javma.249.5.526","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}