{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T13:07:41Z","timestamp":1774098461166,"version":"3.50.1"},"reference-count":52,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2016,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the effect of resveratrol administration in performance horses with lameness localized to the distal tarsal joints.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Randomized, blinded, placebo-controlled clinical trial.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 45 client-owned horses with lameness localized to the distal tarsal joints.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> All horses received injections of triamcinolone acetonide in the centrodistal and tarsometatarsal joints of both hind limbs. A placebo or a supplement containing resveratrol was fed twice daily by owners for 4 months. Primary outcomes were horse performance as determined by rider opinion (better, worse, or the same) and change in lameness severity from the enrollment examination.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Complete data were obtained for 21 horses that received resveratrol and 20 that received the placebo. Percentage of riders who reported that the horse's performance was better, compared with worse or the same, was significantly higher for the resveratrol group than for the placebo group after 2 (20\/21 [95%] vs 14\/20 [70%]) and 4 (18\/21 [86%] vs 10\/20 [50%]) months. The change in A1:A2 ratio between the enrollment and 4-month recheck examinations was significantly better for horses in the resveratrol versus placebo group. However, subjective lameness scores and degree of asymmetry of pelvis movement did not differ between groups.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results suggested that in performance horses with lameness localized to the distal tarsal joints, injection of triamcinolone in the centrodistal and tarsometatarsal joints of both hind limbs followed by oral supplementation with resveratrol for 4 months resulted in reduced lameness, compared with triamcinolone injection and supplementation with a placebo.<\/jats:p>","DOI":"10.2460\/javma.249.6.650","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T15:20:15Z","timestamp":1472743215000},"page":"650-659","source":"Crossref","is-referenced-by-count":15,"title":["A randomized, controlled trial of the effects of resveratrol administration in performance horses with lameness localized to the distal tarsal joints"],"prefix":"10.2460","volume":"249","author":[{"given":"Ashlee E.","family":"Watts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Dabareiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chad","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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(-)-epigallocatechin-3-gallate on the scuticociliate fish pathogen Philasterides dicentrarchi","volume":"59","author":"Leiro","year":"2004"},{"key":"ref14","series-title":"Eur Heart J","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1093\/eurheartj\/ehm149","article-title":"The red wine hypothesis: from concepts to protective signalling molecules","volume":"28","author":"Opie","year":"2007"},{"key":"ref15","series-title":"Biochem Soc Trans","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1042\/BST0351156","article-title":"Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications","volume":"35","author":"de la Lastra","year":"2007"},{"key":"ref16","series-title":"Cell Cycle","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.4161\/cc.7.8.5740","article-title":"Resveratrol: a multitargeted agent for age-associated chronic 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