{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:51:55Z","timestamp":1761094315314,"version":"build-2065373602"},"reference-count":34,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To determine whether anemia, thrombocytopenia, and RBC morphologic changes are identified in canine patients with multiple acquired portosystemic shunts (MAPSS), and to determine whether hematologic abnormalities in dogs with MAPSS correlate with survival. <\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>In a retrospective study from January 2014 to December 2023, CBC, RBC morphology, biochemistry results, diagnostic imaging findings, diagnosis, and survival times were recorded. Dogs were categorized on the basis of suspected MAPSS etiology. <\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Thirty-seven client-owned dogs diagnosed with MAPSS were included. Thirty-five percent of dogs with MAPSS were anemic, with a median RBC concentration of 5.79 X 10<jats:sup>6<\/jats:sup>\/\u00b5L (range, 2.48 X 10<jats:sup>6<\/jats:sup> to 9.11 X 10<jats:sup>6<\/jats:sup>\/\u00b5L; reference interval, 5.4 X 10<jats:sup>6<\/jats:sup> to 8.4 X 10<jats:sup>6<\/jats:sup>\/\u00b5L). Poikilocytosis was identified in 43% of dogs with MAPSS. Thrombocytopenia was reported in 65% of dogs with MAPSS with a median platelet concentration of 177 X 10<jats:sup>3<\/jats:sup>\/\u00b5L (range, 10 X 10<jats:sup>3<\/jats:sup> to 635 X 10<jats:sup>3<\/jats:sup>\/\u00b5L; reference interval, 220 X 10<jats:sup>3<\/jats:sup> to 600 X 10<jats:sup>3<\/jats:sup>\/\u00b5L). Hematologic abnormalities did not correlate with survival. Median survival of dogs with MAPSS was 100 days (range, 0 to 2,217 days; n = 35, with survival data unavailable for 2 dogs). Thirty-five percent of dogs with MAPSS survived for &gt; 1 year after diagnosis. <\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Long-term survival is possible in dogs with MAPSS regardless of hematologic abnormalities. The reduction in platelets in dogs with MAPSS may be caused by splenic sequestration, consumption secondary to vascular shear stress, or coagulation derangements related to the underlying disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>Anemia, poikilocytosis, and thrombocytopenia are not prognostic indicators of survival in dogs with MAPSS.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.25.03.0141","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T17:30:59Z","timestamp":1752687059000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Hematologic abnormalities do not correlate with survival in dogs with multiple acquired portosystemic shunts"],"prefix":"10.2460","volume":"263","author":[{"given":"Loni","family":"Albrecht","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Blue Pearl Pet Hospital\u2013Charlestown, Boston, MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon D.","family":"Dehghanpir","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-8313","authenticated-orcid":true,"given":"Chin-Chi","family":"Liu","sequence":"additional","affiliation":[{"name":"Office of Research and Graduate Education, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Rademacher","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1082-1155","authenticated-orcid":true,"given":"Andrea N.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA"},{"name":"Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI"},{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"2","key":"ref1","series-title":"J Vet Intern Med.","first-page":"169","article-title":"Portal hypertension: pathophysiology, diagnosis, and treatment","volume":"25","author":"Buob S","year":"2011","unstructured":"Buob S, Johnston AN, Webster CR. 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