{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T03:01:52Z","timestamp":1755226912963,"version":"3.43.0"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2025,5,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Objective<\/jats:title>\n<jats:p>To assess the validity of the brachycephalic risk (BRisk) score to correctly predict the risk of complications in dogs undergoing surgery for brachycephalic obstructive airway syndrome (BOAS).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Medical records from January 1, 2020, to December 31, 2024, were retrospectively reviewed. Variables for the BRisk score were collected, and scores were assigned. Area under the curve (AUC) was calculated for the ability of the BRisk score to correctly predict major postoperative complications (oxygen required for &gt; 48 hours, temporary tracheostomy, permanent tracheostomy, and\/or death).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>228 brachycephalic dogs undergoing BOAS surgery were included, of which 29 dogs (12.7%) had major postoperative complications. The median BRisk score for all dogs was 3.5 (range, 0.5 to 9.5). Dogs with a score &gt; 3 were 3.0 times more likely to have major postoperative complications (OR, 3.0; 95% CI, 1.2 to 7.3) compared to dogs with scores \u2264 3. The AUC of the BRisk score for predicting major postoperative complications was 0.719 (95% CI, 0.620 to 0.819). The AUC for French and English Bulldogs was 0.667 (95% CI, 0.527 to 0.806) and 0.754 (95% CI, 0.556 to 0.953), respectively. For breeds other than French or English Bulldog, the AUC was 0.882 (95% CI, 0.757 to 1.000).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The BRisk score had acceptable performance in this population. Performance varied by breed and was worst for French Bulldogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Clinical Relevance<\/jats:title>\n<jats:p>The BRisk score had acceptable performance in this external validation group. A breed-specific BRisk score with excellent to outstanding discrimination may better identify dogs at risk for major postoperative complications following BOAS surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.25.03.0145","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T15:08:47Z","timestamp":1747840127000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["The brachycephalic risk (BRisk) score\u2019s predictability for major postoperative complications varies between breeds undergoing brachycephalic obstructive airway surgery"],"prefix":"10.2460","author":[{"given":"Lauryn M.","family":"Cooper","sequence":"first","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-8013","authenticated-orcid":true,"given":"Janet A.","family":"Grimes","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akaterina M.","family":"Davros","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"3","key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","first-page":"749","article-title":"Brachycephalic obstructive airway syndrome","volume":"52","author":"Krainer D","year":"2022","unstructured":"Krainer D, Dupr\u00e9 G. Brachycephalic obstructive airway syndrome. Vet Clin North Am Small Anim Pract. 2022;52(3):749-780. doi:10.1016\/j.cvsm.2022.01.013"},{"key":"ref2","series-title":"Small Animal Soft Tissue Surgery","article-title":"Brachycephalic airway syndrome","author":"Dupre G","year":"2012","unstructured":"Dupre G, Findji L, Oechtering G. Brachycephalic airway syndrome. In: Monnet E, ed. Small Animal Soft Tissue Surgery. John Wiley & Sons Ltd; 2012. doi:10.1002\/9781118997505.ch19"},{"issue":"9","key":"ref3","series-title":"J Am Vet Med Assoc","first-page":"1324","article-title":"Surgical correction of brachycephalic syndrome in dogs: 62 cases (1991-2004)","volume":"230","author":"Riecks TW","year":"2007","unstructured":"Riecks TW, Birchard SJ, Stephens JA. Surgical correction of brachycephalic syndrome in dogs: 62 cases (1991-2004). J Am Vet Med Assoc. 2007;230(9):1324-1328. doi:10.2460\/javma.230.9.1324"},{"key":"ref4","series-title":"Vet J","first-page":"39","article-title":"How does multilevel upper airway surgery influence the lives of dogs with severe brachycephaly? Results of a structured pre- and postoperative owner questionnaire","volume":"210","author":"Pohl S","year":"2016","unstructured":"Pohl S, Roedler FS, Oechtering GU. How does multilevel upper airway surgery influence the lives of dogs with severe brachycephaly? Results of a structured pre- and postoperative owner questionnaire. Vet J. 2016;210:39-45. doi:10.1016\/j.tvjl.2016.01.017"},{"issue":"2","key":"ref5","series-title":"Vet Surg","first-page":"271","article-title":"Outcomes and prognostic factors of surgical treatments for brachycephalic obstructive airway syndrome in 3 breeds","volume":"46","author":"Liu N-C","year":"2017","unstructured":"Liu N-C, Oechtering GU, Adams VJ, Kalmar L, Sargan DR, Ladlow JF. Outcomes and prognostic factors of surgical treatments for brachycephalic obstructive airway syndrome in 3 breeds. Vet Surg. 2017;46(2):271-280. doi:10.1111\/vsu.12608"},{"issue":"3","key":"ref6","series-title":"J Am Vet Med Assoc","first-page":"301","article-title":"Risk of anesthesia-related complications in brachycephalic dogs","volume":"253","author":"Gruenheid M","year":"2018","unstructured":"Gruenheid M, Aarnes TK, McLoughlin MA,  Risk of anesthesia-related complications in brachycephalic dogs. J Am Vet Med Assoc. 2018;253(3):301-306. doi:10.2460\/javma.253.3.301"},{"issue":"7","key":"ref7","series-title":"Vet Surg","first-page":"1253","article-title":"Development and validation of a brachycephalic risk (BRisk) score to predict the risk of complications in dogs presenting for surgical treatment of brachycephalic obstructive airway syndrome","volume":"48","author":"Tarricone J","year":"2019","unstructured":"Tarricone J, Hayes GM, Singh A, Davis G. Development and validation of a brachycephalic risk (BRisk) score to predict the risk of complications in dogs presenting for surgical treatment of brachycephalic obstructive airway syndrome. Vet Surg. 2019;48(7):1253-1261. doi:10.1111\/vsu.13291"},{"issue":"5","key":"ref8","series-title":"Aust Vet J","first-page":"173","article-title":"Brachycephalic airway syndrome: management of post-operative respiratory complications in 248 dogs","volume":"98","author":"Lindsay B","year":"2020","unstructured":"Lindsay B, Cook D, Wetzel JM, Siess S, Moses P. Brachycephalic airway syndrome: management of post-operative respiratory complications in 248 dogs. Aust Vet J. 2020;98(5):173-180. doi:10.1111\/avj.12926"},{"issue":"4","key":"ref9","series-title":"Vet Surg","first-page":"630","article-title":"Risk factors for complicated perioperative recovery in dogs undergoing staphylectomy or folded flap palatoplasty: seventy-six cases (2018-2022)","volume":"53","author":"Fracka AB","year":"2024","unstructured":"Fracka AB, Song MK, Dejong TL, Fransson BA. Risk factors for complicated perioperative recovery in dogs undergoing staphylectomy or folded flap palatoplasty: seventy-six cases (2018-2022). Vet Surg. 2024;53(4):630-641. doi:10.1111\/vsu.14086"},{"issue":"3","key":"ref10","series-title":"J Small Anim Pract","first-page":"150","article-title":"Results of surgical correction of abnormalities associated with brachycephalic airway obstruction syndrome in dogs in Australia","volume":"47","author":"Torrez CV","year":"2006","unstructured":"Torrez CV, Hunt GB. Results of surgical correction of abnormalities associated with brachycephalic airway obstruction syndrome in dogs in Australia. J Small Anim Pract. 2006;47(3):150-154. doi:10.1111\/j.1748-5827.2006.00059.x"},{"issue":"9","key":"ref11","series-title":"J Am Vet Med Assoc","first-page":"1048","article-title":"Brachycephalic airway obstructive syndrome in dogs: 90 cases (1991-2008)","volume":"237","author":"Fasanella FJ","year":"2010","unstructured":"Fasanella FJ, Shivley JM, Wardlaw JL, Givaruangsawat S. Brachycephalic airway obstructive syndrome in dogs: 90 cases (1991-2008). J Am Vet Med Assoc. 2010;237(9):1048-1051. doi:10.2460\/javma.237.9.1048"},{"issue":"5","key":"ref12","series-title":"Vet Clin North Am Small Anim Pract","first-page":"969","article-title":"Complications of upper airway surgery in companion animals","volume":"41","author":"Mercurio A","year":"2011","unstructured":"Mercurio A. Complications of upper airway surgery in companion animals. Vet Clin North Am Small Anim Pract. 2011;41(5):969-980, vi-vii. doi:10.1016\/j.cvsm.2011.05.016"},{"article-title":"Journal of the American Animal Hospital Association","author":"Body condition scoring (BCS) systems","key":"ref13","unstructured":"Body condition scoring (BCS) systems. Journal of the American Animal Hospital Association. Accessed April 25, 2025. https:\/\/www.aaha.org\/wp-content\/uploads\/globalassets\/02-guidelines\/weight-management\/weightmgmt_bodyconditionscoring.pdf"},{"key":"ref14","first-page":"177","article-title":"Applied Logistic Regression","author":"Hosmer DWJ","year":"2013","unstructured":"Hosmer DWJ, Lemeshow S, Sturdivant RX. Applied Logistic Regression. 3rd ed. John Wiley & Sons Inc; 2013:177. doi:10.1002\/9781118548387"},{"issue":"S1","key":"ref15","series-title":"J Am Vet Med Assoc","first-page":"S65","article-title":"Complications, prognostic factors, and long-term outcomes for dogs with brachycephalic obstructive airway syndrome that underwent H-pharyngoplasty and ala-vestibuloplasty: 423 cases (2011-2017)","volume":"260","author":"Carabalona JPR","year":"2021","unstructured":"Carabalona JPR, Le Boedec K, Poncet CM. Complications, prognostic factors, and long-term outcomes for dogs with brachycephalic obstructive airway syndrome that underwent H-pharyngoplasty and ala-vestibuloplasty: 423 cases (2011-2017). J Am Vet Med Assoc. 2021;260(S1):S65-S73. doi:10.2460\/javma.20.09.0534"},{"issue":"9","key":"ref16","series-title":"Can Vet J","first-page":"976","article-title":"Factors associated with major complications in the short-term postoperative period in dogs undergoing surgery for brachycephalic airway syndrome","volume":"57","author":"Ree JJ","year":"2016","unstructured":"Ree JJ, Milovancev M, MacIntyre LA, Townsend KL. Factors associated with major complications in the short-term postoperative period in dogs undergoing surgery for brachycephalic airway syndrome. Can Vet J. 2016;57(9):976-980."},{"issue":"10","key":"ref17","series-title":"Vet Rec","first-page":"403","article-title":"Prognostic indicators of short-term outcome in dogs undergoing surgery for brachycephalic obstructive airway syndrome","volume":"187","author":"Seneviratne M","year":"2020","unstructured":"Seneviratne M, Kaye BM, Ter Haar G. Prognostic indicators of short-term outcome in dogs undergoing surgery for brachycephalic obstructive airway syndrome. Vet Rec. 2020;187(10):403-403. doi:10.1136\/vr.105624"},{"issue":"11","key":"ref18","series-title":"Vet Rec","first-page":"e1430","article-title":"Impact of an educational intervention on public perception of brachycephalic obstructive airway syndrome in brachycephalic dogs","volume":"190","author":"Kenny DD","year":"2022","unstructured":"Kenny DD, Freemantle R, Jeffery A, Tivers MS. Impact of an educational intervention on public perception of brachycephalic obstructive airway syndrome in brachycephalic dogs. Vet Rec. 2022;190(11):e1430. doi:10.1002\/vetr.1430"},{"issue":"6","key":"ref19","series-title":"PLoS One","first-page":"e0130741","article-title":"Characterization of brachycephalic obstructive airway syndrome in French Bulldogs using whole-body barometric plethysmography","volume":"10","author":"Liu NC","year":"2015","unstructured":"Liu NC, Sargan DR, Adams VJ, Ladlow JF. Characterization of brachycephalic obstructive airway syndrome in French Bulldogs using whole-body barometric plethysmography. 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