{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T23:10:11Z","timestamp":1768605011409,"version":"3.49.0"},"reference-count":100,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Estimate tolerable dietary copper (Cu) intake in senior dogs from a primary care hospital population representing typical pet dog demographics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Liver samples from 104 dogs euthanized for geriatric health concerns were collected from April 7, 2023, to April 22, 2024. Medical records, dietary history, and regional water analyses were acquired. Dietary Cu (manufacturer typical analyses or inductively coupled plasma atomic emission spectroscopy [USDA micronutrient laboratory]) was normalized as mg of Cu\/100 kcal (energy calculations used modified Atwater factorials). Liver samples underwent histological evaluation (H&amp;E, rhodanine), rhodanine Cu scoring, and Cu quantification (\u00b5g\/g of dry weight liver [dwl]). Categorical dietary Cu intakes were Cu-restricted (0.15 to 0.24 mg of Cu\/100 kcal) versus Cu-replete (0.31 to 0.39 and \u2265 0.40 mg of Cu\/100 kcal). Nonparametric statistics defined significant differences and associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>51 male, 53 female, 32 breeds and 29 mixed breeds had median (95% CI) age, weight, and diet duration of 11.6 years (10.6 to 12.1 years), 23.0 kg (20.1 to 25.4 kg), and 8.0 years (7.0 to 8.7 years). No dog fed Cu-restricted diets displayed evidence of Cu insufficiency. Water Cu concentration was 0.12 mg\/L (0.08 to 0.17 mg\/L). Common histological features (glycogen-type vacuolation [n = 61], reactive-hepatitis [20], neoplasia [18]) did not associate with liver Cu concentration. Thirteen dogs fed Cu-restricted diets had significantly lower liver Cu than 91 dogs fed Cu-replete diets. Liver Cu in Cu-restricted-diet dogs did not exceed 355 \u00b5g of Cu\/g of dwl or stain with rhodanine. Among dogs consuming Cu-replete diets were 35 of 91 (38%) with rhodanine positivity, 20 of 91 (22%) with liver Cu \u2265 400 \u00b5g of Cu\/g of dwl (upper reference range), and 14 of 91 (15%) with liver Cu \u2265 600 \u00b5g of Cu\/g of dwl.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Findings demonstrated significantly higher liver Cu concentration with dietary intake \u2265 0.31 mg of Cu\/100 kcal than with dietary intake of 0.15 to 0.24 mg of Cu\/100 kcal. Water was exonerated as a critical Cu source.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Details indicated a tolerable upper Cu intake of 0.24 mg of Cu\/100 kcal in studied dogs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.25.05.0295","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:30:49Z","timestamp":1763749849000},"page":"171-180","source":"Crossref","is-referenced-by-count":0,"title":["Lower risk for liver copper accumulation in dogs fed copper-restricted diets versus those fed copper-replete diets"],"prefix":"10.2460","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5598-2898","authenticated-orcid":true,"given":"Sharon A.","family":"Center","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"VanVranken","sequence":"additional","affiliation":[{"name":"Dickman Road Veterinary Hospital, Battle Creek, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John F.","family":"Randolph","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk","family":"Sapa","sequence":"additional","affiliation":[{"name":"Project volunteer, Ithaca, NY."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben G.","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Dickman Road Veterinary Hospital, Battle Creek, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"McKenzie C.","family":"Hull","sequence":"additional","affiliation":[{"name":"Dickman Road Veterinary Hospital, Battle Creek, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Wakshlag","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Glahn","sequence":"additional","affiliation":[{"name":"Robert W. Holley Center for Agriculture and Health, USDA, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason A.","family":"Wiesinger","sequence":"additional","affiliation":[{"name":"Robert W. Holley Center for Agriculture and Health, USDA, Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"4","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"357","article-title":"Is it time to reconsider current guidelines for copper content in commercial dog foods?","volume":"258","author":"Center SA","year":"2021","unstructured":"Center SA, Richter KP, Twedt DC, Wakshlag JJ, Watson PJ, Webster CRL. Is it time to reconsider current guidelines for copper content in commercial dog foods? J Am Vet Med Assoc. 2021;258(4):357-364. doi:10.2460\/javma.258.4.357"},{"issue":"1","key":"ref2","series-title":"EFSA J","first-page":"e07728","article-title":"EFSA Scientific Committee. Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources","volume":"21","author":"More SJ","year":"2023","unstructured":"More SJ, Bampidis V, Benford D, ; EFSA Scientific Committee. Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources. EFSA J. 2023;21(1):e07728. doi:10.2903\/j.efsa.2023.7728"},{"issue":"8","key":"ref3","series-title":"EFSA J","first-page":"e04563","article-title":"Revision of the currently authorised maximum copper content in complete feed","volume":"14","author":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","year":"2016","unstructured":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). Revision of the currently authorised maximum copper content in complete feed. EFSA J. 2016;14(8):e04563. doi:10.2903\/j.efsa.2016.4563"},{"issue":"1","key":"ref4","series-title":"Environ Manage","first-page":"131","article-title":"Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper","volume":"65","author":"Taylor AA","year":"2020","unstructured":"Taylor AA, Tsuji JS, Garry MR,  Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper. Environ Manage. 2020;65(1):131-159. doi:10.1007\/s00267-019-01234-y. Published correction appears in Environ Manage. 2022;69(5):1051. doi: 10.1007\/s00267-022-01618-7"},{"issue":"1","key":"ref5","series-title":"Signal Transduct Target Ther","first-page":"378","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen L","year":"2022","unstructured":"Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther. 2022;7(1):378. doi:10.1038\/s41392-022-01229-y"},{"issue":"10","key":"ref6","series-title":"Pflugers Arch","first-page":"1415","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"Chen J","year":"2020","unstructured":"Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C. The molecular mechanisms of copper metabolism and its roles in human diseases. Pflugers Arch. 2020;472(10):1415-1429. doi:10.1007\/s00424-020-02412-2"},{"key":"ref7","first-page":"1","article-title":"Environmental Health Criteria 200: Copper","author":"WHO, International Programme on Chemical Safety","year":"1998","unstructured":"WHO, International Programme on Chemical Safety. Environmental Health Criteria 200: Copper. WHO; 1998:1\u2013360."},{"issue":"5","key":"ref8","series-title":"Biol Trace Elem Res","first-page":"2675","article-title":"Copper toxicity in animals: a review","volume":"203","author":"Wang Y","year":"2025","unstructured":"Wang Y, Yan Q, Shi Y, Long M. Copper toxicity in animals: a review. Biol Trace Elem Res. 2025;203(5):2675-2686. doi:10.1007\/s12011-024-04345-8"},{"issue":"4","key":"ref9","series-title":"J Anim Sci","first-page":"1153","article-title":"High level copper for growing-finishing swine","volume":"19","author":"Wallace HD","year":"1960","unstructured":"Wallace HD, McCall JT, Bass B, Gombs GE. High level copper for growing-finishing swine. J Anim Sci. 1960;19(4):1153-1163. doi:10.2527\/jas1960.1941153x"},{"issue":"11","key":"ref10","series-title":"J Anim Sci","first-page":"2996","article-title":"Effects of source and level of copper on performance and liver copper stores in weanling pigs","volume":"67","author":"Cromwell GL","year":"1989","unstructured":"Cromwell GL, Stahly TS, Monegue HJ. Effects of source and level of copper on performance and liver copper stores in weanling pigs. J Anim Sci. 1989;67(11):2996-3002. doi:10.2527\/jas1989.67112996x"},{"issue":"1","key":"ref11","series-title":"Biol Trace Elem Res","first-page":"148","article-title":"Copper and zinc nutritional issues for agricultural animal production","volume":"188","author":"Hill GM","year":"2019","unstructured":"Hill GM, Shannon MC. Copper and zinc nutritional issues for agricultural animal production. Biol Trace Elem Res. 2019;188(1):148-159. doi:10.1007\/s12011-018-1578-5"},{"issue":"5","key":"ref12","series-title":"J Dairy Sci","first-page":"4209","article-title":"Short communication: survey of hepatic copper concentrations in Midwest dairy cows","volume":"102","author":"Strickland JM","year":"2019","unstructured":"Strickland JM, Herdt TH, Sledge DG, Buchweitz JP. Short communication: survey of hepatic copper concentrations in Midwest dairy cows. J Dairy Sci. 2019;102(5):4209-4214. doi:10.3168\/jds.2018-15566"},{"issue":"1","key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"99","article-title":"Chronic copper poisoning in sheep grazing pastures fertilized with swine manure","volume":"198","author":"Kerr LA","year":"1991","unstructured":"Kerr LA, McGavin HD. Chronic copper poisoning in sheep grazing pastures fertilized with swine manure. J Am Vet Med Assoc. 1991;198(1):99-101. doi:10.2460\/javma.1991.198.01.99"},{"issue":"3","key":"ref14","series-title":"J Vet Sci","first-page":"e31","article-title":"Excessive copper in feed not merely undermines animal health but affects food safety","volume":"22","author":"Ma Z","year":"2021","unstructured":"Ma Z, Li Y, Han Z,  Excessive copper in feed not merely undermines animal health but affects food safety. J Vet Sci. 2021;22(3):e31. doi:10.4142\/jvs.2021.22.e31"},{"issue":"23","key":"ref15","series-title":"J Agric Food Chem","first-page":"6943","article-title":"Latent benefits and toxicity risks transmission chain of high dietary copper along the livestock-environment-plant-human health axis and microbial homeostasis: a review","volume":"70","author":"Zhen Y","year":"2022","unstructured":"Zhen Y, Ge L, Chen Q,  Latent benefits and toxicity risks transmission chain of high dietary copper along the livestock-environment-plant-human health axis and microbial homeostasis: a review. J Agric Food Chem. 2022;70(23):6943-6962. doi:10.1021\/acs.jafc.2c01367"},{"key":"ref16","article-title":"Copper in Dog Foods Expert Panel final report with recommendation to the pet food committee","author":"Association of American Feed Control Officials","unstructured":"Association of American Feed Control Officials. Copper in Dog Foods Expert Panel final report with recommendation to the pet food committee. Modified July 12, 2022. Accessed February 22, 2025. Accessed July 20, 2025. https:\/\/www.aafco.org\/wp-content\/uploads\/2023\/01\/Copper_in_Dog_Foods_Expert_Panel_Report_to_the_PFCkv2136684-2136685.pdf"},{"key":"ref17","article-title":"Association of American Feed Control Officials Pet Food Committee annual report: appendix B","author":"Association of American Feed Control Officials","year":"2013","unstructured":"Association of American Feed Control Officials. Association of American Feed Control Officials Pet Food Committee annual report: appendix B. 2013. Accessed July 20, 2025. https:\/\/www.aafco.org\/wp-content\/uploads\/2023\/01\/Pet_Food_Report_2013_Annual-Appendix_B.pdf"},{"key":"ref18","first-page":"360","article-title":"Nutrient Requirements of Dogs and Cats","volume":"172","author":"National Research Council Ad Hoc Committee on Dog and Cat Nutrition","year":"2006","unstructured":"National Research Council Ad Hoc Committee on Dog and Cat Nutrition. Nutrient Requirements of Dogs and Cats. National Academy Press; 2006:172, 360\u2013362."},{"issue":"3-4","key":"ref19","series-title":"FASEB J","first-page":"A305","article-title":"Copper bioavailability and requirement in the dog: comparison of copper oxide and copper sulfate","volume":"7","author":"Czarnecki-Maulden GL","year":"1993","unstructured":"Czarnecki-Maulden GL, Rudnick RC, Chausow DG. Copper bioavailability and requirement in the dog: comparison of copper oxide and copper sulfate. FASEB J. 1993;7(3-4):A305. Abstract 1769."},{"issue":"12","key":"ref20","series-title":"J Am Vet Med Assoc","first-page":"1602","article-title":"Pet population continues to increase while pet spending declines. Preliminary results from 2024 AVMA pet ownership and demographic survey were presented at 2024 AVMA veterinary economic and business forum","volume":"262","author":"Larkin M","year":"2024","unstructured":"Larkin M. Pet population continues to increase while pet spending declines. Preliminary results from 2024 AVMA pet ownership and demographic survey were presented at 2024 AVMA veterinary economic and business forum. J Am Vet Med Assoc. 2024;262(12):1602-1603."},{"issue":"11","key":"ref21","series-title":"Nutrients","first-page":"1609","article-title":"The fast cooking and enhanced iron bioavailability properties of the Manteca yellow bean (Phaseolus vulgaris L.)","volume":"10","author":"Wiesinger JA","year":"2018","unstructured":"Wiesinger JA, Cichy KA, Tako E, Glahn RP. The fast cooking and enhanced iron bioavailability properties of the Manteca yellow bean (Phaseolus vulgaris L.). Nutrients. 2018;10(11):1609. doi:10.3390\/nu10111609"},{"key":"ref22","article-title":"FoodData Central","author":"USDA Agricultural Research Service","unstructured":"USDA Agricultural Research Service. FoodData Central. Accessed October 15, 2025. https:\/\/fdc.nal.usda.gov\/"},{"issue":"12","key":"ref23","series-title":"Am J Vet Res","first-page":"1474","article-title":"Digital image analysis of rhodanine-stained liver biopsy specimens for calculation of hepatic copper concentrations in dogs","volume":"74","author":"Center SA","year":"2013","unstructured":"Center SA, McDonough SP, Bogdanovic L. Digital image analysis of rhodanine-stained liver biopsy specimens for calculation of hepatic copper concentrations in dogs. Am J Vet Res. 2013;74(12):1474-1480. doi:10.2460\/ajvr.74.12.1474"},{"issue":"4","key":"ref24","series-title":"J Am Vet Med Assoc","first-page":"395","article-title":"Disparities in hepatic copper concentrations determined by atomic absorption spectroscopy, inductively coupled plasma mass spectrometry, and digital image analysis of rhodanine-stained sections in dogs","volume":"258","author":"Miller AJ","year":"2021","unstructured":"Miller AJ, Center SA, Randolph JF, Friesen CH, Miller AD, Warner KW. Disparities in hepatic copper concentrations determined by atomic absorption spectroscopy, inductively coupled plasma mass spectrometry, and digital image analysis of rhodanine-stained sections in dogs. J Am Vet Med Assoc. 2021;258(4):395-406. doi:10.2460\/javma.258.4.395"},{"issue":"1","key":"ref25","series-title":"Bull Johns Hopkins Hosp","first-page":"41","article-title":"The anemia of copper deficiency in dogs compared with that produced by iron deficiency","volume":"93","author":"Van Wyk JJ","year":"1953","unstructured":"Van Wyk JJ, Baxter JH, Akeroyd JH, Motulsky AG. The anemia of copper deficiency in dogs compared with that produced by iron deficiency. Bull Johns Hopkins Hosp. 1953;93(1):41-49."},{"issue":"1","key":"ref26","series-title":"Bull Johns Hopkins Hosp","first-page":"1","article-title":"A bone disorder associated with copper deficiency. I. Gross morphological, roentgenological, and chemical observations","volume":"93","author":"Baxter JH","year":"1953","unstructured":"Baxter JH, Van Wyk JJ. A bone disorder associated with copper deficiency. I. Gross morphological, roentgenological, and chemical observations. Bull Johns Hopkins Hosp. 1953;93(1):1-23."},{"issue":"suppl 11","key":"ref27","series-title":"J Nutr","first-page":"S83","article-title":"Investigations on copper deficiency in growing dogs","volume":"121","author":"Zentek J","year":"1991","unstructured":"Zentek J, Meyer H. Investigations on copper deficiency in growing dogs. J Nutr. 1991;121(suppl 11):S83-S84. doi:10.1093\/jn\/121.suppl_11.S83"},{"issue":"2","key":"ref28","series-title":"Am J Vet Res","first-page":"330","article-title":"Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs","volume":"66","author":"Center SA","year":"2005","unstructured":"Center SA, Warner KL, McCabe J, Foureman P, Hoffmann WE, Erb HN. Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am J Vet Res. 2005;66(2):330-341. doi:10.2460\/ajvr.2005.66.330"},{"key":"ref29","article-title":"US Environmental Protection Agency","author":"Lead and copper rule: a quick reference guide for schools and child care facilities that are regulated under the safe drinking water act","unstructured":"Lead and copper rule: a quick reference guide for schools and child care facilities that are regulated under the safe drinking water act. US Environmental Protection Agency. Updated October 2005. Accessed July 1, 2025. https:\/\/www.epa.gov\/dwreginfo\/lead-and-copper-rule"},{"issue":"14","key":"ref30","series-title":"J Am Vet Med Assoc","first-page":"1","article-title":"ATP7A, ATP7B, and RETN genotypes in Labrador Retrievers with and without copper-associated hepatopathy","volume":"260","author":"Langlois DK","year":"2022","unstructured":"Langlois DK, Nagler BSM, Smedley RC, Yang YT, Yuzbasiyan-Gurkan V. ATP7A, ATP7B, and RETN genotypes in Labrador Retrievers with and without copper-associated hepatopathy. J Am Vet Med Assoc. 2022;260(14):1-8. doi:10.2460\/javma.21.12.0541"},{"issue":"5","key":"ref31","series-title":"J Vet Intern Med","first-page":"957","article-title":"Dietary management of hepatic copper accumulation in Labrador Retrievers","volume":"23","author":"Hoffmann G","year":"2009","unstructured":"Hoffmann G, Jones PG, Biourge V,  Dietary management of hepatic copper accumulation in Labrador Retrievers. J Vet Intern Med. 2009;23(5):957-963. doi:10.1111\/j.1939-1676.2009.0352.x"},{"issue":"3","key":"ref32","series-title":"Vet J","first-page":"429","article-title":"Nutritional management of inherited copper-associated hepatitis in the Labrador Retriever","volume":"199","author":"Fieten H","year":"2014","unstructured":"Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J. Nutritional management of inherited copper-associated hepatitis in the Labrador Retriever. Vet J. 2014;199(3):429-433. doi:10.1016\/j.tvjl.2013.12.017"},{"issue":"3","key":"ref33","series-title":"J Vet Intern Med","first-page":"1173","article-title":"ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs","volume":"33","author":"Webster CRL","year":"2019","unstructured":"Webster CRL, Center SA, Cullen JM,  ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. J Vet Intern Med. 2019;33(3):1173-1200. doi:10.1111\/jvim.15467"},{"key":"ref34","series-title":"J Am Vet Med Assoc","article-title":"Lifetime survival: surgical versus medical management of portosystemic vascular anomalies in dogs with and without copper-restricted liver diets (1980-2015)","author":"Center SA","unstructured":"Center SA, Randolph JF, Warner KL,  Lifetime survival: surgical versus medical management of portosystemic vascular anomalies in dogs with and without copper-restricted liver diets (1980-2015). J Am Vet Med Assoc. Published online November XX, 2025. doi:10.2460\/javma.25.05.0296"},{"issue":"2","key":"ref35","series-title":"Risk Anal","first-page":"211","article-title":"Recommended reference values for risk assessment of oral exposure to copper","volume":"43","author":"Taylor AA","year":"2023","unstructured":"Taylor AA, Tsuji JS, McArdle ME, Adams WJ, Goodfellow WL Jr. Recommended reference values for risk assessment of oral exposure to copper. Risk Anal. 2023;43(2):211-218. doi:10.1111\/risa.13906"},{"issue":"2","key":"ref36","series-title":"J Vet Diagn Invest","first-page":"101","article-title":"A perspective on copper and liver disease in the dog","volume":"12","author":"Thornburg LP","year":"2000","unstructured":"Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagn Invest. 2000;12(2):101-110. doi:10.1177\/104063870001200201"},{"issue":"11","key":"ref37","series-title":"Arch Toxicol","first-page":"1929","article-title":"Copper: toxicological relevance and mechanisms","volume":"88","author":"Gaetke LM","year":"2014","unstructured":"Gaetke LM, Chow-Johnson HS, Chow CK. Copper: toxicological relevance and mechanisms. Arch Toxicol. 2014;88(11):1929-1938. doi:10.1007\/s00204-014-1355-y"},{"issue":"9-10","key":"ref38","series-title":"Apoptosis","first-page":"1330","article-title":"Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases","volume":"29","author":"Yang Z","year":"2024","unstructured":"Yang Z, Feng R, Zhao H. Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases. Apoptosis. 2024;29(9-10):1330-1360. doi:10.1007\/s10495-024-01993-y"},{"issue":"6","key":"ref39","series-title":"J Vet Intern Med","first-page":"1943","article-title":"Hepatic copper concentrations in 546 dogs (1982-2015)","volume":"32","author":"Strickland JM","year":"2018","unstructured":"Strickland JM, Buchweitz JP, Smedley RC,  Hepatic copper concentrations in 546 dogs (1982-2015). J Vet Intern Med. 2018;32(6):1943-1950. doi:10.1111\/jvim.15308"},{"issue":"9","key":"ref40","series-title":"Biomedicines","first-page":"356","article-title":"Accurate measurement of copper overload in an experimental model of Wilson disease by laser ablation inductively coupled plasma mass spectrometry","volume":"8","author":"Kim P","year":"2020","unstructured":"Kim P, Zhang CC, Thor\u00f6e-Boveleth S,  Accurate measurement of copper overload in an experimental model of Wilson disease by laser ablation inductively coupled plasma mass spectrometry. Biomedicines. 2020;8(9):356. doi:10.3390\/biomedicines8090356"},{"issue":"6","key":"ref41","series-title":"Am J Pathol","first-page":"883","article-title":"Changes in the distribution of hepatic copper in relation to the progression of Wilson\u2019s disease (hepatolenticular degeneration)","volume":"53","author":"Goldfischer S","year":"1968","unstructured":"Goldfischer S, Sternlieb I. Changes in the distribution of hepatic copper in relation to the progression of Wilson\u2019s disease (hepatolenticular degeneration). Am J Pathol. 1968;53(6):883-901."},{"issue":"7","key":"ref42","series-title":"J Toxicol Clin Toxicol","first-page":"709","article-title":"Effect of age and sex on liver damage due to excess dietary copper in Fischer 344 rats","volume":"38","author":"Fuentealba IC","year":"2000","unstructured":"Fuentealba IC, Mullins JE, Aburto EM, Lau JC, Cherian GM. Effect of age and sex on liver damage due to excess dietary copper in Fischer 344 rats. J Toxicol Clin Toxicol. 2000;38(7):709-717. doi:10.1081\/CLT-100102384"},{"key":"ref43","series-title":"J Trace Elem Med Biol","first-page":"269","article-title":"A study of dose response and organ susceptibility of copper toxicity in a rat model","volume":"29","author":"Kumar V","year":"2015","unstructured":"Kumar V, Kalita J, Misra UK, Bora HK. A study of dose response and organ susceptibility of copper toxicity in a rat model. J Trace Elem Med Biol. 2015;29:269-274. doi:10.1016\/j.jtemb.2014.06.004"},{"issue":"2","key":"ref44","series-title":"J Nutr","first-page":"233","article-title":"Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses","volume":"142","author":"Araya M","year":"2012","unstructured":"Araya M, N\u00fa\u00f1ez H, Pavez L,  Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr. 2012;142(2):233-237. doi:10.3945\/jn.111.140103"},{"key":"ref45","series-title":"J Inorg Biochem","first-page":"106","article-title":"Liver pathology in Wilson\u2019s disease: from copper overload to cirrhosis","volume":"193","author":"Gerosa C","year":"2019","unstructured":"Gerosa C, Fanni D, Congiu T,  Liver pathology in Wilson\u2019s disease: from copper overload to cirrhosis. J Inorg Biochem. 2019;193:106-111. doi:10.1016\/j.jinorgbio.2019.01.008"},{"issue":"3","key":"ref46","series-title":"Cell Mol Gastroenterol Hepatol","first-page":"571","article-title":"A high-calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats","volume":"7","author":"Einer C","year":"2019","unstructured":"Einer C, Leitzinger C, Lichtmannegger J,  A high-calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats. Cell Mol Gastroenterol Hepatol. 2019;7(3):571-596. doi:10.1016\/j.jcmgh.2018.12.005"},{"key":"ref47","series-title":"One-Year Chronic Oral Toxicity of Copper Gluconate W\/02\/09A in Beagle Dogs","author":"Shanaman JE","year":"1972","unstructured":"Shanaman JE, Wazeter FX, Goldenthal El. One-Year Chronic Oral Toxicity of Copper Gluconate W\/02\/09A in Beagle Dogs. Warner-Lambert Research Institute; 1972. Research report No. 955-0353."},{"issue":"5","key":"ref48","series-title":"Adv Nutr","first-page":"1102","article-title":"Why the derivation of nutrient reference values should be harmonized and how it can be accomplished","volume":"11","author":"Yaktine AL","year":"2020","unstructured":"Yaktine AL, King JC, Allen LH. Why the derivation of nutrient reference values should be harmonized and how it can be accomplished. Adv Nutr. 2020;11(5):1102-1107. doi:10.1093\/advances\/nmaa048. Published correction appears in Adv Nutr. 2022;13(3):974. doi: 10.1093\/advances\/nmaa155"},{"key":"ref49","series-title":"Transl Anim Sci","first-page":"txad147","article-title":"Copper metabolism and its implications for canine nutrition","volume":"8","author":"Amundson LA","year":"2024","unstructured":"Amundson LA, Kirn BN, Swensson EJ, Millican AA, Fahey GC. Copper metabolism and its implications for canine nutrition. Transl Anim Sci. 2024;8:txad147. doi:10.1093\/tas\/txad147"},{"key":"ref50","article-title":"\u2018Seniors\u2019 are a growing part of the pet population","author":"Sprinkle D","unstructured":"Sprinkle D. \u2018Seniors\u2019 are a growing part of the pet population. GlobalPETS. November 25, 2022. Accessed February 8, 2025. https:\/\/globalpetindustry.com\/article\/seniors-are-growing-part-pet-population\/"},{"issue":"4","key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"357","article-title":"Is it time to reconsider current guidelines for copper content in commercial dog foods?","volume":"258","author":"Center SA","year":"2021","unstructured":"Center SA, Richter KP, Twedt DC, Wakshlag JJ, Watson PJ, Webster CRL. Is it time to reconsider current guidelines for copper content in commercial dog foods? J Am Vet Med Assoc. 2021;258(4):357-364. doi:10.2460\/javma.258.4.357"},{"issue":"1","key":"ref2","series-title":"EFSA J","first-page":"e07728","article-title":"EFSA Scientific Committee. Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources","volume":"21","author":"More SJ","year":"2023","unstructured":"More SJ, Bampidis V, Benford D, ; EFSA Scientific Committee. Re-evaluation of the existing health-based guidance values for copper and exposure assessment from all sources. EFSA J. 2023;21(1):e07728. doi:10.2903\/j.efsa.2023.7728"},{"issue":"8","key":"ref3","series-title":"EFSA J","first-page":"e04563","article-title":"Revision of the currently authorised maximum copper content in complete feed","volume":"14","author":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)","year":"2016","unstructured":"EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). Revision of the currently authorised maximum copper content in complete feed. EFSA J. 2016;14(8):e04563. doi:10.2903\/j.efsa.2016.4563"},{"issue":"1","key":"ref4","series-title":"Environ Manage","first-page":"131","article-title":"Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper","volume":"65","author":"Taylor AA","year":"2020","unstructured":"Taylor AA, Tsuji JS, Garry MR,  Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper. Environ Manage. 2020;65(1):131-159. doi:10.1007\/s00267-019-01234-y. Published correction appears in Environ Manage. 2022;69(5):1051. doi: 10.1007\/s00267-022-01618-7"},{"issue":"1","key":"ref5","series-title":"Signal Transduct Target Ther","first-page":"378","article-title":"Copper homeostasis and cuproptosis in health and disease","volume":"7","author":"Chen L","year":"2022","unstructured":"Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther. 2022;7(1):378. doi:10.1038\/s41392-022-01229-y"},{"issue":"10","key":"ref6","series-title":"Pflugers Arch","first-page":"1415","article-title":"The molecular mechanisms of copper metabolism and its roles in human diseases","volume":"472","author":"Chen J","year":"2020","unstructured":"Chen J, Jiang Y, Shi H, Peng Y, Fan X, Li C. The molecular mechanisms of copper metabolism and its roles in human diseases. Pflugers Arch. 2020;472(10):1415-1429. doi:10.1007\/s00424-020-02412-2"},{"key":"ref7","first-page":"1","article-title":"Environmental Health Criteria 200: Copper","author":"WHO, International Programme on Chemical Safety","year":"1998","unstructured":"WHO, International Programme on Chemical Safety. Environmental Health Criteria 200: Copper. WHO; 1998:1\u2013360."},{"issue":"5","key":"ref8","series-title":"Biol Trace Elem Res","first-page":"2675","article-title":"Copper toxicity in animals: a review","volume":"203","author":"Wang Y","year":"2025","unstructured":"Wang Y, Yan Q, Shi Y, Long M. Copper toxicity in animals: a review. Biol Trace Elem Res. 2025;203(5):2675-2686. doi:10.1007\/s12011-024-04345-8"},{"issue":"4","key":"ref9","series-title":"J Anim Sci","first-page":"1153","article-title":"High level copper for growing-finishing swine","volume":"19","author":"Wallace HD","year":"1960","unstructured":"Wallace HD, McCall JT, Bass B, Gombs GE. High level copper for growing-finishing swine. J Anim Sci. 1960;19(4):1153-1163. doi:10.2527\/jas1960.1941153x"},{"issue":"11","key":"ref10","series-title":"J Anim Sci","first-page":"2996","article-title":"Effects of source and level of copper on performance and liver copper stores in weanling pigs","volume":"67","author":"Cromwell GL","year":"1989","unstructured":"Cromwell GL, Stahly TS, Monegue HJ. Effects of source and level of copper on performance and liver copper stores in weanling pigs. J Anim Sci. 1989;67(11):2996-3002. doi:10.2527\/jas1989.67112996x"},{"issue":"1","key":"ref11","series-title":"Biol Trace Elem Res","first-page":"148","article-title":"Copper and zinc nutritional issues for agricultural animal production","volume":"188","author":"Hill GM","year":"2019","unstructured":"Hill GM, Shannon MC. Copper and zinc nutritional issues for agricultural animal production. Biol Trace Elem Res. 2019;188(1):148-159. doi:10.1007\/s12011-018-1578-5"},{"issue":"5","key":"ref12","series-title":"J Dairy Sci","first-page":"4209","article-title":"Short communication: survey of hepatic copper concentrations in Midwest dairy cows","volume":"102","author":"Strickland JM","year":"2019","unstructured":"Strickland JM, Herdt TH, Sledge DG, Buchweitz JP. Short communication: survey of hepatic copper concentrations in Midwest dairy cows. J Dairy Sci. 2019;102(5):4209-4214. doi:10.3168\/jds.2018-15566"},{"issue":"1","key":"ref13","series-title":"J Am Vet Med Assoc","first-page":"99","article-title":"Chronic copper poisoning in sheep grazing pastures fertilized with swine manure","volume":"198","author":"Kerr LA","year":"1991","unstructured":"Kerr LA, McGavin HD. Chronic copper poisoning in sheep grazing pastures fertilized with swine manure. J Am Vet Med Assoc. 1991;198(1):99-101. doi:10.2460\/javma.1991.198.01.99"},{"issue":"3","key":"ref14","series-title":"J Vet Sci","first-page":"e31","article-title":"Excessive copper in feed not merely undermines animal health but affects food safety","volume":"22","author":"Ma Z","year":"2021","unstructured":"Ma Z, Li Y, Han Z,  Excessive copper in feed not merely undermines animal health but affects food safety. J Vet Sci. 2021;22(3):e31. doi:10.4142\/jvs.2021.22.e31"},{"issue":"23","key":"ref15","series-title":"J Agric Food Chem","first-page":"6943","article-title":"Latent benefits and toxicity risks transmission chain of high dietary copper along the livestock-environment-plant-human health axis and microbial homeostasis: a review","volume":"70","author":"Zhen Y","year":"2022","unstructured":"Zhen Y, Ge L, Chen Q,  Latent benefits and toxicity risks transmission chain of high dietary copper along the livestock-environment-plant-human health axis and microbial homeostasis: a review. J Agric Food Chem. 2022;70(23):6943-6962. doi:10.1021\/acs.jafc.2c01367"},{"key":"ref16","article-title":"Copper in Dog Foods Expert Panel final report with recommendation to the pet food committee","author":"Association of American Feed Control Officials","unstructured":"Association of American Feed Control Officials. Copper in Dog Foods Expert Panel final report with recommendation to the pet food committee. Modified July 12, 2022. Accessed February 22, 2025. Accessed July 20, 2025. https:\/\/www.aafco.org\/wp-content\/uploads\/2023\/01\/Copper_in_Dog_Foods_Expert_Panel_Report_to_the_PFCkv2136684-2136685.pdf"},{"key":"ref17","article-title":"Association of American Feed Control Officials Pet Food Committee annual report: appendix B","author":"Association of American Feed Control Officials","year":"2013","unstructured":"Association of American Feed Control Officials. Association of American Feed Control Officials Pet Food Committee annual report: appendix B. 2013. Accessed July 20, 2025. https:\/\/www.aafco.org\/wp-content\/uploads\/2023\/01\/Pet_Food_Report_2013_Annual-Appendix_B.pdf"},{"key":"ref18","first-page":"360","article-title":"Nutrient Requirements of Dogs and Cats","volume":"172","author":"National Research Council Ad Hoc Committee on Dog and Cat Nutrition","year":"2006","unstructured":"National Research Council Ad Hoc Committee on Dog and Cat Nutrition. Nutrient Requirements of Dogs and Cats. National Academy Press; 2006:172, 360\u2013362."},{"issue":"3-4","key":"ref19","series-title":"FASEB J","first-page":"A305","article-title":"Copper bioavailability and requirement in the dog: comparison of copper oxide and copper sulfate","volume":"7","author":"Czarnecki-Maulden GL","year":"1993","unstructured":"Czarnecki-Maulden GL, Rudnick RC, Chausow DG. Copper bioavailability and requirement in the dog: comparison of copper oxide and copper sulfate. FASEB J. 1993;7(3-4):A305. Abstract 1769."},{"issue":"12","key":"ref20","series-title":"J Am Vet Med Assoc","first-page":"1602","article-title":"Pet population continues to increase while pet spending declines. Preliminary results from 2024 AVMA pet ownership and demographic survey were presented at 2024 AVMA veterinary economic and business forum","volume":"262","author":"Larkin M","year":"2024","unstructured":"Larkin M. Pet population continues to increase while pet spending declines. Preliminary results from 2024 AVMA pet ownership and demographic survey were presented at 2024 AVMA veterinary economic and business forum. J Am Vet Med Assoc. 2024;262(12):1602-1603."},{"issue":"11","key":"ref21","series-title":"Nutrients","first-page":"1609","article-title":"The fast cooking and enhanced iron bioavailability properties of the Manteca yellow bean (Phaseolus vulgaris L.)","volume":"10","author":"Wiesinger JA","year":"2018","unstructured":"Wiesinger JA, Cichy KA, Tako E, Glahn RP. The fast cooking and enhanced iron bioavailability properties of the Manteca yellow bean (Phaseolus vulgaris L.). Nutrients. 2018;10(11):1609. doi:10.3390\/nu10111609"},{"key":"ref22","article-title":"FoodData Central","author":"USDA Agricultural Research Service","unstructured":"USDA Agricultural Research Service. FoodData Central. Accessed October 15, 2025. https:\/\/fdc.nal.usda.gov\/"},{"issue":"12","key":"ref23","series-title":"Am J Vet Res","first-page":"1474","article-title":"Digital image analysis of rhodanine-stained liver biopsy specimens for calculation of hepatic copper concentrations in dogs","volume":"74","author":"Center SA","year":"2013","unstructured":"Center SA, McDonough SP, Bogdanovic L. Digital image analysis of rhodanine-stained liver biopsy specimens for calculation of hepatic copper concentrations in dogs. Am J Vet Res. 2013;74(12):1474-1480. doi:10.2460\/ajvr.74.12.1474"},{"issue":"4","key":"ref24","series-title":"J Am Vet Med Assoc","first-page":"395","article-title":"Disparities in hepatic copper concentrations determined by atomic absorption spectroscopy, inductively coupled plasma mass spectrometry, and digital image analysis of rhodanine-stained sections in dogs","volume":"258","author":"Miller AJ","year":"2021","unstructured":"Miller AJ, Center SA, Randolph JF, Friesen CH, Miller AD, Warner KW. Disparities in hepatic copper concentrations determined by atomic absorption spectroscopy, inductively coupled plasma mass spectrometry, and digital image analysis of rhodanine-stained sections in dogs. J Am Vet Med Assoc. 2021;258(4):395-406. doi:10.2460\/javma.258.4.395"},{"issue":"1","key":"ref25","series-title":"Bull Johns Hopkins Hosp","first-page":"41","article-title":"The anemia of copper deficiency in dogs compared with that produced by iron deficiency","volume":"93","author":"Van Wyk JJ","year":"1953","unstructured":"Van Wyk JJ, Baxter JH, Akeroyd JH, Motulsky AG. The anemia of copper deficiency in dogs compared with that produced by iron deficiency. Bull Johns Hopkins Hosp. 1953;93(1):41-49."},{"issue":"1","key":"ref26","series-title":"Bull Johns Hopkins Hosp","first-page":"1","article-title":"A bone disorder associated with copper deficiency. I. Gross morphological, roentgenological, and chemical observations","volume":"93","author":"Baxter JH","year":"1953","unstructured":"Baxter JH, Van Wyk JJ. A bone disorder associated with copper deficiency. I. Gross morphological, roentgenological, and chemical observations. Bull Johns Hopkins Hosp. 1953;93(1):1-23."},{"issue":"suppl 11","key":"ref27","series-title":"J Nutr","first-page":"S83","article-title":"Investigations on copper deficiency in growing dogs","volume":"121","author":"Zentek J","year":"1991","unstructured":"Zentek J, Meyer H. Investigations on copper deficiency in growing dogs. J Nutr. 1991;121(suppl 11):S83-S84. doi:10.1093\/jn\/121.suppl_11.S83"},{"issue":"2","key":"ref28","series-title":"Am J Vet Res","first-page":"330","article-title":"Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs","volume":"66","author":"Center SA","year":"2005","unstructured":"Center SA, Warner KL, McCabe J, Foureman P, Hoffmann WE, Erb HN. Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. Am J Vet Res. 2005;66(2):330-341. doi:10.2460\/ajvr.2005.66.330"},{"key":"ref29","article-title":"US Environmental Protection Agency","author":"Lead and copper rule: a quick reference guide for schools and child care facilities that are regulated under the safe drinking water act","unstructured":"Lead and copper rule: a quick reference guide for schools and child care facilities that are regulated under the safe drinking water act. US Environmental Protection Agency. Updated October 2005. Accessed July 1, 2025. https:\/\/www.epa.gov\/dwreginfo\/lead-and-copper-rule"},{"issue":"14","key":"ref30","series-title":"J Am Vet Med Assoc","first-page":"1","article-title":"ATP7A, ATP7B, and RETN genotypes in Labrador Retrievers with and without copper-associated hepatopathy","volume":"260","author":"Langlois DK","year":"2022","unstructured":"Langlois DK, Nagler BSM, Smedley RC, Yang YT, Yuzbasiyan-Gurkan V. ATP7A, ATP7B, and RETN genotypes in Labrador Retrievers with and without copper-associated hepatopathy. J Am Vet Med Assoc. 2022;260(14):1-8. doi:10.2460\/javma.21.12.0541"},{"issue":"5","key":"ref31","series-title":"J Vet Intern Med","first-page":"957","article-title":"Dietary management of hepatic copper accumulation in Labrador Retrievers","volume":"23","author":"Hoffmann G","year":"2009","unstructured":"Hoffmann G, Jones PG, Biourge V,  Dietary management of hepatic copper accumulation in Labrador Retrievers. J Vet Intern Med. 2009;23(5):957-963. doi:10.1111\/j.1939-1676.2009.0352.x"},{"issue":"3","key":"ref32","series-title":"Vet J","first-page":"429","article-title":"Nutritional management of inherited copper-associated hepatitis in the Labrador Retriever","volume":"199","author":"Fieten H","year":"2014","unstructured":"Fieten H, Biourge VC, Watson AL, Leegwater PA, van den Ingh TS, Rothuizen J. Nutritional management of inherited copper-associated hepatitis in the Labrador Retriever. Vet J. 2014;199(3):429-433. doi:10.1016\/j.tvjl.2013.12.017"},{"issue":"3","key":"ref33","series-title":"J Vet Intern Med","first-page":"1173","article-title":"ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs","volume":"33","author":"Webster CRL","year":"2019","unstructured":"Webster CRL, Center SA, Cullen JM,  ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs. J Vet Intern Med. 2019;33(3):1173-1200. doi:10.1111\/jvim.15467"},{"key":"ref34","series-title":"J Am Vet Med Assoc","article-title":"Lifetime survival: surgical versus medical management of portosystemic vascular anomalies in dogs with and without copper-restricted liver diets (1980-2015)","author":"Center SA","unstructured":"Center SA, Randolph JF, Warner KL,  Lifetime survival: surgical versus medical management of portosystemic vascular anomalies in dogs with and without copper-restricted liver diets (1980-2015). J Am Vet Med Assoc. Published online November XX, 2025. doi:10.2460\/javma.25.05.0296"},{"issue":"2","key":"ref35","series-title":"Risk Anal","first-page":"211","article-title":"Recommended reference values for risk assessment of oral exposure to copper","volume":"43","author":"Taylor AA","year":"2023","unstructured":"Taylor AA, Tsuji JS, McArdle ME, Adams WJ, Goodfellow WL Jr. Recommended reference values for risk assessment of oral exposure to copper. Risk Anal. 2023;43(2):211-218. doi:10.1111\/risa.13906"},{"issue":"2","key":"ref36","series-title":"J Vet Diagn Invest","first-page":"101","article-title":"A perspective on copper and liver disease in the dog","volume":"12","author":"Thornburg LP","year":"2000","unstructured":"Thornburg LP. A perspective on copper and liver disease in the dog. J Vet Diagn Invest. 2000;12(2):101-110. doi:10.1177\/104063870001200201"},{"issue":"11","key":"ref37","series-title":"Arch Toxicol","first-page":"1929","article-title":"Copper: toxicological relevance and mechanisms","volume":"88","author":"Gaetke LM","year":"2014","unstructured":"Gaetke LM, Chow-Johnson HS, Chow CK. Copper: toxicological relevance and mechanisms. Arch Toxicol. 2014;88(11):1929-1938. doi:10.1007\/s00204-014-1355-y"},{"issue":"9-10","key":"ref38","series-title":"Apoptosis","first-page":"1330","article-title":"Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases","volume":"29","author":"Yang Z","year":"2024","unstructured":"Yang Z, Feng R, Zhao H. Cuproptosis and Cu: a new paradigm in cellular death and their role in non-cancerous diseases. Apoptosis. 2024;29(9-10):1330-1360. doi:10.1007\/s10495-024-01993-y"},{"issue":"6","key":"ref39","series-title":"J Vet Intern Med","first-page":"1943","article-title":"Hepatic copper concentrations in 546 dogs (1982-2015)","volume":"32","author":"Strickland JM","year":"2018","unstructured":"Strickland JM, Buchweitz JP, Smedley RC,  Hepatic copper concentrations in 546 dogs (1982-2015). J Vet Intern Med. 2018;32(6):1943-1950. doi:10.1111\/jvim.15308"},{"issue":"9","key":"ref40","series-title":"Biomedicines","first-page":"356","article-title":"Accurate measurement of copper overload in an experimental model of Wilson disease by laser ablation inductively coupled plasma mass spectrometry","volume":"8","author":"Kim P","year":"2020","unstructured":"Kim P, Zhang CC, Thor\u00f6e-Boveleth S,  Accurate measurement of copper overload in an experimental model of Wilson disease by laser ablation inductively coupled plasma mass spectrometry. Biomedicines. 2020;8(9):356. doi:10.3390\/biomedicines8090356"},{"issue":"6","key":"ref41","series-title":"Am J Pathol","first-page":"883","article-title":"Changes in the distribution of hepatic copper in relation to the progression of Wilson\u2019s disease (hepatolenticular degeneration)","volume":"53","author":"Goldfischer S","year":"1968","unstructured":"Goldfischer S, Sternlieb I. Changes in the distribution of hepatic copper in relation to the progression of Wilson\u2019s disease (hepatolenticular degeneration). Am J Pathol. 1968;53(6):883-901."},{"issue":"7","key":"ref42","series-title":"J Toxicol Clin Toxicol","first-page":"709","article-title":"Effect of age and sex on liver damage due to excess dietary copper in Fischer 344 rats","volume":"38","author":"Fuentealba IC","year":"2000","unstructured":"Fuentealba IC, Mullins JE, Aburto EM, Lau JC, Cherian GM. Effect of age and sex on liver damage due to excess dietary copper in Fischer 344 rats. J Toxicol Clin Toxicol. 2000;38(7):709-717. doi:10.1081\/CLT-100102384"},{"key":"ref43","series-title":"J Trace Elem Med Biol","first-page":"269","article-title":"A study of dose response and organ susceptibility of copper toxicity in a rat model","volume":"29","author":"Kumar V","year":"2015","unstructured":"Kumar V, Kalita J, Misra UK, Bora HK. A study of dose response and organ susceptibility of copper toxicity in a rat model. J Trace Elem Med Biol. 2015;29:269-274. doi:10.1016\/j.jtemb.2014.06.004"},{"issue":"2","key":"ref44","series-title":"J Nutr","first-page":"233","article-title":"Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses","volume":"142","author":"Araya M","year":"2012","unstructured":"Araya M, N\u00fa\u00f1ez H, Pavez L,  Administration of high doses of copper to capuchin monkeys does not cause liver damage but induces transcriptional activation of hepatic proliferative responses. J Nutr. 2012;142(2):233-237. doi:10.3945\/jn.111.140103"},{"key":"ref45","series-title":"J Inorg Biochem","first-page":"106","article-title":"Liver pathology in Wilson\u2019s disease: from copper overload to cirrhosis","volume":"193","author":"Gerosa C","year":"2019","unstructured":"Gerosa C, Fanni D, Congiu T,  Liver pathology in Wilson\u2019s disease: from copper overload to cirrhosis. J Inorg Biochem. 2019;193:106-111. doi:10.1016\/j.jinorgbio.2019.01.008"},{"issue":"3","key":"ref46","series-title":"Cell Mol Gastroenterol Hepatol","first-page":"571","article-title":"A high-calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats","volume":"7","author":"Einer C","year":"2019","unstructured":"Einer C, Leitzinger C, Lichtmannegger J,  A high-calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats. Cell Mol Gastroenterol Hepatol. 2019;7(3):571-596. doi:10.1016\/j.jcmgh.2018.12.005"},{"key":"ref47","series-title":"One-Year Chronic Oral Toxicity of Copper Gluconate W\/02\/09A in Beagle Dogs","author":"Shanaman JE","year":"1972","unstructured":"Shanaman JE, Wazeter FX, Goldenthal El. One-Year Chronic Oral Toxicity of Copper Gluconate W\/02\/09A in Beagle Dogs. Warner-Lambert Research Institute; 1972. Research report No. 955-0353."},{"issue":"5","key":"ref48","series-title":"Adv Nutr","first-page":"1102","article-title":"Why the derivation of nutrient reference values should be harmonized and how it can be accomplished","volume":"11","author":"Yaktine AL","year":"2020","unstructured":"Yaktine AL, King JC, Allen LH. Why the derivation of nutrient reference values should be harmonized and how it can be accomplished. Adv Nutr. 2020;11(5):1102-1107. doi:10.1093\/advances\/nmaa048. Published correction appears in Adv Nutr. 2022;13(3):974. doi: 10.1093\/advances\/nmaa155"},{"key":"ref49","series-title":"Transl Anim Sci","first-page":"txad147","article-title":"Copper metabolism and its implications for canine nutrition","volume":"8","author":"Amundson LA","year":"2024","unstructured":"Amundson LA, Kirn BN, Swensson EJ, Millican AA, Fahey GC. Copper metabolism and its implications for canine nutrition. Transl Anim Sci. 2024;8:txad147. doi:10.1093\/tas\/txad147"},{"key":"ref50","article-title":"\u2018Seniors\u2019 are a growing part of the pet population","author":"Sprinkle D","unstructured":"Sprinkle D. \u2018Seniors\u2019 are a growing part of the pet population. GlobalPETS. November 25, 2022. 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