{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T14:45:22Z","timestamp":1789829122908,"version":"4.0.1"},"reference-count":102,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n To determine the effectiveness of anesthesia-free dentistry (AFD) versus anesthetic dentistry for treatment of periodontal disease in dogs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This prospective study was conducted between April 16, 2014, and October 21, 2014. Client-owned dogs were assigned an initial periodontal diagnostic test strip (PDTS) score (from 0 [white] to 5 [dark yellow]) during conscious oral examination using commercially available rapid test strips to assess salivary concentration of thiols (OraStripdx; PDX Biotech LLC). Eligible dogs included those with PDTS score \u2265 3 and no previous dental cleaning (control group) and those with any PDTS score and a history of AFD in the previous 6 weeks. Because of this timeframe, the initial PDTS scores for the experimental group also served as a post-AFD PDTS score. All dogs in the control group and 14 of 23 dogs in the experimental group underwent anesthetized dental procedures. Periodontal disease was assessed under anesthesia, and PDTS scores were reassessed at recheck examination. Results were compared between groups.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n 46 dogs were included, 23 in each group. Mean PDTS score was significantly lower at recheck examination after anesthetic dentistry for both groups. Mean initial PDTS score did not differ significantly between groups; however, the mean PDTS score at recheck examination was significantly lower for dogs after an anesthetized dental procedure (0.087; range, 0 to 1) versus AFD (4.35; range, 3 to 5).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n No medical benefit was provided by AFD.<\/jats:p>\n <\/jats:sec>\n \n Clinical Relevance<\/jats:title>\n AFD is not a viable alternative to an anesthetized dental procedure for periodontal disease mitigation.<\/jats:p>\n <\/jats:sec>","DOI":"10.2460\/javma.25.06.0405","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T14:32:20Z","timestamp":1761748340000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Anesthesia-free dentistry does not provide any demonstrable medical benefit for the control of periodontal disease in dogs"],"prefix":"10.2460","volume":"264","author":[{"given":"Brook A.","family":"Niemiec","sequence":"first","affiliation":[{"name":"Veterinary Dental Specialties & Oral Surgery, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine B.","family":"Kangas","sequence":"additional","affiliation":[{"name":"Integrative Veterinary Care, San Diego, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin P.","family":"Ribka","sequence":"additional","affiliation":[{"name":"Gulf South Veterinary Dental Specialties, New Orleans, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","article-title":"American Veterinary Dental College","author":"Position statement: companion animal dental scaling without anesthesia","unstructured":"Position statement: companion animal dental scaling without anesthesia. American Veterinary Dental College. April 10, 2004. Accessed July 1, 2025. avdc.org\/wp-content\/uploads\/2019\/AVDC-pos-stmts\/Dental_Scaling_Without_Anesthesia.pdf"},{"key":"ref2","article-title":"American Animal Hospital Association","author":"Nonanesthetic dentistry","unstructured":"Nonanesthetic dentistry. American Animal Hospital Association. May 3, 2019. Accessed July 1, 2025. www.aaha.org\/resources\/2019-aaha-dental-care-guidelines-for-dogs-and-cats\/nonanesthetic-dentistry\/"},{"issue":"7","key":"ref3","series-title":"J Small Anim Pract","first-page":"E36","article-title":"World Small Animal Veterinary Association global dental guidelines","volume":"61","author":"Niemiec B","year":"2020","unstructured":"Niemiec B, Gawor J, Nemec A, World Small Animal Veterinary Association global dental guidelines. J Small Anim Pract. 2020;61(7):E36-E161. doi:10.1111\/jsap.13132"},{"key":"ref4","article-title":"California Department of Consumer Affairs Veterinary Medical Board","author":"Dental Regulations (Practice of Veterinary Medicine Defined): Regulations Regarding Who Can Perform Dental Procedures","unstructured":"Dental Regulations (Practice of Veterinary Medicine Defined): Regulations Regarding Who Can Perform Dental Procedures. California Department of Consumer Affairs Veterinary Medical Board. Accessed July 1, 2025. www.vmb.ca.gov\/laws_regs\/dental.shtml"},{"key":"ref5","article-title":"NAC 638.730","author":"Veterinary dentistry: requirements; exception; definition","unstructured":"Veterinary dentistry: requirements; exception; definition. NAC 638.730. Accessed July 1, 2025. https:\/\/www.leg.state.nv.us\/nac\/nac-638.html#NAC638Sec730"},{"key":"ref6","article-title":"College of Veterinarians of Ontario","author":"Veterinary dentistry","unstructured":"Veterinary dentistry. College of Veterinarians of Ontario. March 2015. Revised July 2023. Accessed July 1, 2025. www.cvo.org\/standards\/veterinary-dentistry"},{"key":"ref7","article-title":"College of Veterinarians of Ontario","author":"College Council caution public on the use of cosmetic teeth cleaning services","unstructured":"College Council caution public on the use of cosmetic teeth cleaning services. College of Veterinarians of Ontario. November 6, 2017. Accessed July 1, 2025. www.cvo.org\/publications\/college-cautions-public-on-use-of-cosmetic-teeth-cleaning-services"},{"issue":"1","key":"ref8","series-title":"PLoS One","first-page":"e0191395","article-title":"A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois","volume":"13","author":"Stella JL","year":"2018","unstructured":"Stella JL, Bauer AE, Croney CC. A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois. PLoS One. 2018;13(1):e0191395. doi:10.1371\/journal.pone.0191395"},{"key":"ref9","article-title":"Australian Veterinary Association","author":"Anesthesia-free dentistry in dogs and cats","unstructured":"Anesthesia-free dentistry in dogs and cats. Australian Veterinary Association. December 9, 2016. Accessed January 1, 2025. https:\/\/www.ava.com.au\/policy-advocacy\/policies\/companion-animals-health\/anaesthesia-free-dentistry-in-dogs-and-cats\/"},{"issue":"5","key":"ref10","series-title":"Vet Anaesth Analg","first-page":"365","article-title":"The risk of death: the confidential enquiry into perioperative small animal fatalities","volume":"35","author":"Brodbelt DC","year":"2008","unstructured":"Brodbelt DC, Blissitt KJ, Hammond RA, The risk of death: the confidential enquiry into perioperative small animal fatalities. Vet Anaesth Analg. 2008;35(5):365-373. doi:10.1111\/j.1467-2995.2008.00397.x"},{"issue":"5","key":"ref11","series-title":"Br J Anaesth","first-page":"617","article-title":"Risk factors for anaesthetic-related death in cats: results from the confidential enquiry into perioperative small animal fatalities (CEPSAF)","volume":"99","author":"Brodbelt DC","year":"2007","unstructured":"Brodbelt DC, Pfeiffer DU, Young LE, Wood JL. Risk factors for anaesthetic-related death in cats: results from the confidential enquiry into perioperative small animal fatalities (CEPSAF). Br J Anaesth. 2007;99(5):617-623. doi:10.1093\/bja\/aem229"},{"issue":"6","key":"ref12","series-title":"J Am Vet Med Assoc","first-page":"655","article-title":"Factors associated with anesthetic-related death in dogs and cats in primary care veterinary hospitals","volume":"250","author":"Matthews NS","year":"2017","unstructured":"Matthews NS, Mohn TJ, Yang M, Factors associated with anesthetic-related death in dogs and cats in primary care veterinary hospitals. J Am Vet Med Assoc. 2017;250(6):655-665. doi:10.2460\/javma.250.6.655"},{"issue":"9","key":"ref13","series-title":"J Small Anim Pract","first-page":"560","article-title":"A longitudinal assessment of periodontal health status in 53 Labrador Retrievers","volume":"59","author":"Wallis C","year":"2018","unstructured":"Wallis C, Patel KV, Marshall M, A longitudinal assessment of periodontal health status in 53 Labrador Retrievers. J Small Anim Pract. 2018;59(9):560-569. doi:10.1111\/jsap.12870"},{"key":"ref14","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"39","article-title":"Oral examination","author":"Huffman LJ","year":"2010","unstructured":"Huffman LJ. Oral examination. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:39\u201361. doi:10.1201\/b18171-3"},{"issue":"4","key":"ref15","series-title":"Veterinary Clin North Am Small Anim Pract","first-page":"781","article-title":"The gold standard of veterinary oral health care","volume":"35","author":"Colmery B III","year":"2005","unstructured":"Colmery B III. The gold standard of veterinary oral health care. Veterinary Clin North Am Small Anim Pract. 2005;35(4):781-787. doi:10.1016\/j.cvsm.2005.02.005"},{"issue":"3","key":"ref16","series-title":"J Vet Dent","first-page":"175","article-title":"Professional teeth cleaning","volume":"20","author":"Niemiec BA","year":"2003","unstructured":"Niemiec BA. Professional teeth cleaning. J Vet Dent. 2003;20(3):175-180. doi:10.1177\/089875640302000305"},{"key":"ref17","series-title":"Small Animal Dental Equipment, Materials, and Techniques: A Primer","first-page":"13","article-title":"Equipping the dental practice","author":"Bellows J","year":"2004","unstructured":"Bellows J. Equipping the dental practice. In: Bellows J, ed. Small Animal Dental Equipment, Materials, and Techniques: A Primer. Blackwell; 2004:13\u201355. doi:10.1002\/9780470344873.ch2"},{"key":"ref18","series-title":"Veterinary Dental Techniques","first-page":"175","article-title":"Dental prophylaxis and periodontal disease stages","author":"Holmstrolm SE","year":"2002","unstructured":"Holmstrolm SE, Frost P, Eisner ER. Dental prophylaxis and periodontal disease stages. In: Veterinary Dental Techniques. 3rd ed. Saunders; 2002:175\u2013232."},{"key":"ref19","series-title":"Veterinary Periodontology","first-page":"129","article-title":"The complete dental cleaning","author":"Niemiec BA","year":"2013","unstructured":"Niemiec BA. The complete dental cleaning. In: Niemiec BA, ed. Veterinary Periodontology. Wiley Blackwell; 2013:129\u2013153."},{"issue":"24","key":"ref20","series-title":"Tijdschr Diergeneeskd","first-page":"920","article-title":"Professional teeth cleaning is more than plaque removal. Professionele gebitsreiniging is wat anders dan tandsteen verwijderen. Rondbeltarieven of een verrichtingenlijst?","volume":"131","author":"van Foreest A","year":"2006","unstructured":"van Foreest A. Professional teeth cleaning is more than plaque removal. Professionele gebitsreiniging is wat anders dan tandsteen verwijderen. Rondbeltarieven of een verrichtingenlijst? Tijdschr Diergeneeskd. 2006;131(24):920-923."},{"issue":"12","key":"ref21","series-title":"Can Vet J","first-page":"1260","article-title":"Pilot evaluation of a novel test strip for the assessment of dissolved thiol levels, as an indicator of canine gingival health and periodontal status","volume":"53","author":"Manfra Marretta S","year":"2012","unstructured":"Manfra Marretta S, Leesman M, Burgess-Cassler A, McClure GD Jr, Buelow M, Finn M. Pilot evaluation of a novel test strip for the assessment of dissolved thiol levels, as an indicator of canine gingival health and periodontal status. Can Vet J. 2012;53(12):1260-1265."},{"issue":"3","key":"ref22","series-title":"J Am Anim Hosp Assoc","first-page":"132","article-title":"Oral-fluid thiol-detection test identifies underlying active periodontal disease not detected by the visual awake examination","volume":"54","author":"Queck KE","year":"2018","unstructured":"Queck KE, Chapman A, Herzog LJ, Shell-Martin T, Burgess-Cassler A, McClure GD. Oral-fluid thiol-detection test identifies underlying active periodontal disease not detected by the visual awake examination. J Am Anim Hosp Assoc. 2018;54(3):132-137. doi:10.5326\/JAAHA-MS-6607"},{"issue":"5","key":"ref23","series-title":"Gen Dent","first-page":"50","article-title":"Salivary thiol levels and periodontal parameters assessed with a chromogenic strip","volume":"61","author":"Khocht A","year":"2013","unstructured":"Khocht A, Seyedain M, Hardan S, Gaughan J, Suzuki JB. Salivary thiol levels and periodontal parameters assessed with a chromogenic strip. Gen Dent. 2013;61(5):50-54."},{"key":"ref24","article-title":"Package insert","author":"Orastrip DX thiol test","year":"2011","unstructured":"Orastrip DX thiol test. Package insert. PDX Biotech LLC; 2011."},{"key":"ref25","article-title":"Package insert","author":"Oravet","year":"2025","unstructured":"Oravet. Package insert. Boehringer Ingelheim; 2025."},{"issue":"9","key":"ref26","series-title":"J Am Vet Med Assoc","first-page":"1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"Lund EM","year":"1999","unstructured":"Lund EM, Armstrong PJ, Kirk CA, Kolar LM, Klausner JS. Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. J Am Vet Med Assoc. 1999;214(9):1336-1341. doi:10.2460\/javma.1999.214.09.1336"},{"issue":"4","key":"ref27","series-title":"Rev Ceres","first-page":"446","article-title":"Prevalence of periodontal disease in dogs and owners\u2019 level of awareness - a prospective clinical trial. Preval\u00eancia da doen\u00e7a periodontal em c\u00e3es e ci\u00eancia dos propriet\u00e1rios a respeito da doen\u00e7a","volume":"59","author":"Fernandes NA","year":"2012","unstructured":"Fernandes NA, Batista Borges AP, Carlo Reis EC, Sep\u00falveda RV, de Sousa Pontes KC. Prevalence of periodontal disease in dogs and owners\u2019 level of awareness - a prospective clinical trial. Preval\u00eancia da doen\u00e7a periodontal em c\u00e3es e ci\u00eancia dos propriet\u00e1rios a respeito da doen\u00e7a. Rev Ceres. 2012;59(4):446-451. doi:10.1590\/S0034-737X2012000400003"},{"issue":"4","key":"ref28","series-title":"Clin Tech Small Anim Pract","first-page":"243","article-title":"Oronasal fistula repair","volume":"15","author":"Smith MM","year":"2000","unstructured":"Smith MM. Oronasal fistula repair. Clin Tech Small Anim Pract. 2000;15(4):243-250. doi:10.1053\/svms.2000.21398"},{"issue":"5","key":"ref29","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1285","article-title":"Maxillofacial surgery","volume":"28","author":"Marretta SM","year":"1998","unstructured":"Marretta SM. Maxillofacial surgery. Vet Clin North Am Small Anim Pract. 1998;28(5):1285-1296, viii. doi:10.1016\/S0195-5616(98)50114-3"},{"key":"ref30","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"199","article-title":"Problems with muscles, bones, and joints","author":"Taney KG","year":"2010","unstructured":"Taney KG, Smith MM. Problems with muscles, bones, and joints. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:199\u2013204. doi:10.1201\/b18171-9"},{"issue":"2","key":"ref31","series-title":"Top Companion Anim Med","first-page":"72","article-title":"Periodontal disease","volume":"23","author":"Niemiec BA","year":"2008","unstructured":"Niemiec BA. Periodontal disease. Top Companion Anim Med. 2008;23(2):72-80. doi:10.1053\/j.tcam.2008.02.003"},{"issue":"2","key":"ref32","series-title":"Orbit","first-page":"221","article-title":"Orbital cellulitis and osteomyelitis secondary to odontogenic infection with campylobacter rectus: a case report","volume":"42","author":"Goswami P","year":"2023","unstructured":"Goswami P, Ie A, O\u2019Donnell BA. Orbital cellulitis and osteomyelitis secondary to odontogenic infection with campylobacter rectus: a case report. Orbit. 2023;42(2):221-223. doi:10.1080\/01676830.2021.1990349"},{"issue":"3","key":"ref33","series-title":"J Am Anim Hosp Assoc","first-page":"215","article-title":"Ophthalmic manifestations and complications of dental disease in dogs and cats","volume":"32","author":"Ramsey DT","year":"1996","unstructured":"Ramsey DT, Marretta SM, Hamor RE, Ophthalmic manifestations and complications of dental disease in dogs and cats. J Am Anim Hosp Assoc. 1996;32(3):215-224. doi:10.5326\/15473317-32-3-215"},{"issue":"2","key":"ref34","series-title":"Vet Ophthalmol","first-page":"106","article-title":"Nasolacrimal obstruction caused by root abscess of the upper canine in a cat","volume":"13","author":"Anthony JM","year":"2010","unstructured":"Anthony JM, Sandmeyer LS, Laycock AR. Nasolacrimal obstruction caused by root abscess of the upper canine in a cat. Vet Ophthalmol. 2010;13(2):106-109. doi:10.1111\/j.1463-5224.2009.00754.x"},{"issue":"3","key":"ref35","series-title":"J Clin Diagn Res","first-page":"ZD08","article-title":"Resection and regeneration - a novel approach in treating a perio-endo lesion","volume":"9","author":"Varughese V","year":"2015","unstructured":"Varughese V, Mahendra J, Thomas AR, Ambalavanan N. Resection and regeneration - a novel approach in treating a perio-endo lesion. J Clin Diagn Res. 2015;9(3):ZD08-ZD10. doi:10.7860\/JCDR\/2015\/11096.5643"},{"key":"ref36","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"127","article-title":"Problems with the dental hard tissues","author":"DuPont GG","year":"2010","unstructured":"DuPont GG. Problems with the dental hard tissues. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:127\u2013157. doi:10.1201\/b18171-6"},{"issue":"3","key":"ref37","series-title":"J Vet Dent","first-page":"160","article-title":"Successful treatment of mandibular nonunion with cortical allograft, cancellous autograft, and locking titanium miniplates in a dog","volume":"33","author":"Snyder CJ","year":"2016","unstructured":"Snyder CJ, Bleedorn JA, Soukup JW. Successful treatment of mandibular nonunion with cortical allograft, cancellous autograft, and locking titanium miniplates in a dog. J Vet Dent. 2016;33(3):160-169. doi:10.1177\/0898756416671060"},{"issue":"26","key":"ref38","series-title":"Oncotarget","first-page":"22613","article-title":"Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model","volume":"6","author":"Binder Gallimidi A","year":"2015","unstructured":"Binder Gallimidi A, Fischman S, Revach B, Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6(26):22613-22623. doi:10.18632\/oncotarget.4209"},{"issue":"3","key":"ref39","series-title":"Appl Microbiol Biotechnol","first-page":"1393","article-title":"The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma","volume":"103","author":"Chang C","year":"2019","unstructured":"Chang C, Geng F, Shi X, The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma. Appl Microbiol Biotechnol. 2019;103(3):1393-1404. doi:10.1007\/s00253-018-9475-6"},{"issue":"1","key":"ref40","series-title":"BMC Oral Health","first-page":"640","article-title":"Periodontitis as a risk for oral cancer: a case-control study","volume":"21","author":"Koml\u00f3s G","year":"2021","unstructured":"Koml\u00f3s G, Csurgay K, Horv\u00e1th F, Pelyhe L, N\u00e9meth Z. Periodontitis as a risk for oral cancer: a case-control study. BMC Oral Health. 2021;21(1):640. doi:10.1186\/s12903-021-01998-y"},{"issue":"2","key":"ref41","series-title":"J Vet Dent","first-page":"97","article-title":"Periodontal disease burden and pathological changes in organs of dogs","volume":"25","author":"Pavlica Z","year":"2008","unstructured":"Pavlica Z, Petelin M, Juntes P, Erzen D, Crossley DA, Skaleric U. Periodontal disease burden and pathological changes in organs of dogs. J Vet Dent. 2008;25(2):97-105. doi:10.1177\/089875640802500210"},{"issue":"2","key":"ref42","series-title":"J Vet Dent","first-page":"57","article-title":"Association of periodontal disease and histologic lesions in multiple organs from 45 dogs","volume":"13","author":"DeBowes LJ","year":"1996","unstructured":"DeBowes LJ, Mosier D, Logan E, Harvey CE, Lowry S, Richardson DC. Association of periodontal disease and histologic lesions in multiple organs from 45 dogs. J Vet Dent. 1996;13(2):57-60. doi:10.1177\/089875649601300201"},{"issue":"7","key":"ref43","series-title":"PLoS One","first-page":"e0255310","article-title":"The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats","volume":"16","author":"Hall JA","year":"2021","unstructured":"Hall JA, Forman FJ, Bobe G, Farace G, Yerramilli M. The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats. PLoS One. 2021;16(7):e0255310. doi:10.1371\/journal.pone.0255310"},{"issue":"4","key":"ref44","series-title":"J Am Vet Med Assoc","first-page":"486","article-title":"Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs","volume":"234","author":"Glickman LT","year":"2009","unstructured":"Glickman LT, Glickman NW, Moore GE, Goldstein GS, Lewis HB. Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs. J Am Vet Med Assoc. 2009;234(4):486-494. doi:10.2460\/javma.234.4.486"},{"issue":"4","key":"ref45","series-title":"J Vet Intern Med","first-page":"216","article-title":"Cholestasis associated with extrahepatic bacterial infection in five dogs","volume":"3","author":"Taboada J","year":"1989","unstructured":"Taboada J, Meyer DJ. Cholestasis associated with extrahepatic bacterial infection in five dogs. J Vet Intern Med. 1989;3(4):216-221. doi:10.1111\/j.1939-1676.1989.tb00860.x"},{"issue":"2","key":"ref46","series-title":"Open Vet J","first-page":"210","article-title":"Periodontal disease is associated with cognitive dysfunction in aging dogs: a blinded prospective comparison of visual periodontal and cognitive questionnaire scores","volume":"11","author":"Dewey CW","year":"2021","unstructured":"Dewey CW, Rishniw M. Periodontal disease is associated with cognitive dysfunction in aging dogs: a blinded prospective comparison of visual periodontal and cognitive questionnaire scores. Open Vet J. 2021;11(2):210-216. doi:10.5455\/OVJ.2021.v11.i2.4"},{"issue":"3","key":"ref47","series-title":"Vet Sci","first-page":"99","article-title":"Correlation between oxidative stress markers and periodontal disease in dogs","volume":"11","author":"Pe\u0219tean CP","year":"2024","unstructured":"Pe\u0219tean CP, Pocquet H, Dumitra\u0219 DA, Morohoschi AG, \u015etef\u0103nu\u0163 LC, Andrei S. Correlation between oxidative stress markers and periodontal disease in dogs. Vet Sci. 2024;11(3):99-103. doi:10.3390\/vetsci11030099"},{"issue":"1","key":"ref48","series-title":"BMC Oral Health","first-page":"266","article-title":"Correlation between whole salivary prostaglandin E2 and hemoglobin A1c levels among type-2 diabetic and non-diabetic patients with periodontal inflammation","volume":"24","author":"Shaheen MY","year":"2024","unstructured":"Shaheen MY, Basudan AM, Alzawawi AS, Correlation between whole salivary prostaglandin E2 and hemoglobin A1c levels among type-2 diabetic and non-diabetic patients with periodontal inflammation. BMC Oral Health. 2024;24(1):266. doi:10.1186\/s12903-024-04032-z"},{"issue":"10","key":"ref49","series-title":"J Dent Res","first-page":"962","article-title":"Association between periodontal diseases and the risk of site-specific gastrointestinal cancers: a systematic review and meta-analysis","volume":"103","author":"Wang Q","year":"2024","unstructured":"Wang Q, Gu WJ, Ning FL, Association between periodontal diseases and the risk of site-specific gastrointestinal cancers: a systematic review and meta-analysis. J Dent Res. 2024;103(10):962-972. doi:10.1177\/00220345241263768"},{"issue":"7","key":"ref50","series-title":"J Am Geriatr Soc","first-page":"1206","article-title":"Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up","volume":"57","author":"Avlund K","year":"2009","unstructured":"Avlund K, Schultz-Larsen K, Krustrup U, Christiansen N, Holm-Pedersen P. Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up. J Am Geriatr Soc. 2009;57(7):1206-1212. doi:10.1111\/j.1532-5415.2009.02328.x"},{"issue":"2","key":"ref51","series-title":"J Am Anim Hosp Assoc","first-page":"49","article-title":"2019 AAHA dental care guidelines for dogs and cats","volume":"55","author":"Bellows J","year":"2019","unstructured":"Bellows J, Berg ML, Dennis S, 2019 AAHA dental care guidelines for dogs and cats. J Am Anim Hosp Assoc. 2019;55(2):49-69. doi:10.5326\/JAAHA-MS-6933"},{"key":"ref1","article-title":"American Veterinary Dental College","author":"Position statement: companion animal dental scaling without anesthesia","unstructured":"Position statement: companion animal dental scaling without anesthesia. American Veterinary Dental College. April 10, 2004. Accessed July 1, 2025. avdc.org\/wp-content\/uploads\/2019\/AVDC-pos-stmts\/Dental_Scaling_Without_Anesthesia.pdf"},{"key":"ref2","article-title":"American Animal Hospital Association","author":"Nonanesthetic dentistry","unstructured":"Nonanesthetic dentistry. American Animal Hospital Association. May 3, 2019. Accessed July 1, 2025. www.aaha.org\/resources\/2019-aaha-dental-care-guidelines-for-dogs-and-cats\/nonanesthetic-dentistry\/"},{"issue":"7","key":"ref3","series-title":"J Small Anim Pract","first-page":"E36","article-title":"World Small Animal Veterinary Association global dental guidelines","volume":"61","author":"Niemiec B","year":"2020","unstructured":"Niemiec B, Gawor J, Nemec A, World Small Animal Veterinary Association global dental guidelines. J Small Anim Pract. 2020;61(7):E36-E161. doi:10.1111\/jsap.13132"},{"key":"ref4","article-title":"California Department of Consumer Affairs Veterinary Medical Board","author":"Dental Regulations (Practice of Veterinary Medicine Defined): Regulations Regarding Who Can Perform Dental Procedures","unstructured":"Dental Regulations (Practice of Veterinary Medicine Defined): Regulations Regarding Who Can Perform Dental Procedures. California Department of Consumer Affairs Veterinary Medical Board. Accessed July 1, 2025. www.vmb.ca.gov\/laws_regs\/dental.shtml"},{"key":"ref5","article-title":"NAC 638.730","author":"Veterinary dentistry: requirements; exception; definition","unstructured":"Veterinary dentistry: requirements; exception; definition. NAC 638.730. Accessed July 1, 2025. https:\/\/www.leg.state.nv.us\/nac\/nac-638.html#NAC638Sec730"},{"key":"ref6","article-title":"College of Veterinarians of Ontario","author":"Veterinary dentistry","unstructured":"Veterinary dentistry. College of Veterinarians of Ontario. March 2015. Revised July 2023. Accessed July 1, 2025. www.cvo.org\/standards\/veterinary-dentistry"},{"key":"ref7","article-title":"College of Veterinarians of Ontario","author":"College Council caution public on the use of cosmetic teeth cleaning services","unstructured":"College Council caution public on the use of cosmetic teeth cleaning services. College of Veterinarians of Ontario. November 6, 2017. Accessed July 1, 2025. www.cvo.org\/publications\/college-cautions-public-on-use-of-cosmetic-teeth-cleaning-services"},{"issue":"1","key":"ref8","series-title":"PLoS One","first-page":"e0191395","article-title":"A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois","volume":"13","author":"Stella JL","year":"2018","unstructured":"Stella JL, Bauer AE, Croney CC. A cross-sectional study to estimate prevalence of periodontal disease in a population of dogs (Canis familiaris) in commercial breeding facilities in Indiana and Illinois. PLoS One. 2018;13(1):e0191395. doi:10.1371\/journal.pone.0191395"},{"key":"ref9","article-title":"Australian Veterinary Association","author":"Anesthesia-free dentistry in dogs and cats","unstructured":"Anesthesia-free dentistry in dogs and cats. Australian Veterinary Association. December 9, 2016. Accessed January 1, 2025. https:\/\/www.ava.com.au\/policy-advocacy\/policies\/companion-animals-health\/anaesthesia-free-dentistry-in-dogs-and-cats\/"},{"issue":"5","key":"ref10","series-title":"Vet Anaesth Analg","first-page":"365","article-title":"The risk of death: the confidential enquiry into perioperative small animal fatalities","volume":"35","author":"Brodbelt DC","year":"2008","unstructured":"Brodbelt DC, Blissitt KJ, Hammond RA, The risk of death: the confidential enquiry into perioperative small animal fatalities. Vet Anaesth Analg. 2008;35(5):365-373. doi:10.1111\/j.1467-2995.2008.00397.x"},{"issue":"5","key":"ref11","series-title":"Br J Anaesth","first-page":"617","article-title":"Risk factors for anaesthetic-related death in cats: results from the confidential enquiry into perioperative small animal fatalities (CEPSAF)","volume":"99","author":"Brodbelt DC","year":"2007","unstructured":"Brodbelt DC, Pfeiffer DU, Young LE, Wood JL. Risk factors for anaesthetic-related death in cats: results from the confidential enquiry into perioperative small animal fatalities (CEPSAF). Br J Anaesth. 2007;99(5):617-623. doi:10.1093\/bja\/aem229"},{"issue":"6","key":"ref12","series-title":"J Am Vet Med Assoc","first-page":"655","article-title":"Factors associated with anesthetic-related death in dogs and cats in primary care veterinary hospitals","volume":"250","author":"Matthews NS","year":"2017","unstructured":"Matthews NS, Mohn TJ, Yang M, Factors associated with anesthetic-related death in dogs and cats in primary care veterinary hospitals. J Am Vet Med Assoc. 2017;250(6):655-665. doi:10.2460\/javma.250.6.655"},{"issue":"9","key":"ref13","series-title":"J Small Anim Pract","first-page":"560","article-title":"A longitudinal assessment of periodontal health status in 53 Labrador Retrievers","volume":"59","author":"Wallis C","year":"2018","unstructured":"Wallis C, Patel KV, Marshall M, A longitudinal assessment of periodontal health status in 53 Labrador Retrievers. J Small Anim Pract. 2018;59(9):560-569. doi:10.1111\/jsap.12870"},{"key":"ref14","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"39","article-title":"Oral examination","author":"Huffman LJ","year":"2010","unstructured":"Huffman LJ. Oral examination. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:39\u201361. doi:10.1201\/b18171-3"},{"issue":"4","key":"ref15","series-title":"Veterinary Clin North Am Small Anim Pract","first-page":"781","article-title":"The gold standard of veterinary oral health care","volume":"35","author":"Colmery B III","year":"2005","unstructured":"Colmery B III. The gold standard of veterinary oral health care. Veterinary Clin North Am Small Anim Pract. 2005;35(4):781-787. doi:10.1016\/j.cvsm.2005.02.005"},{"issue":"3","key":"ref16","series-title":"J Vet Dent","first-page":"175","article-title":"Professional teeth cleaning","volume":"20","author":"Niemiec BA","year":"2003","unstructured":"Niemiec BA. Professional teeth cleaning. J Vet Dent. 2003;20(3):175-180. doi:10.1177\/089875640302000305"},{"key":"ref17","series-title":"Small Animal Dental Equipment, Materials, and Techniques: A Primer","first-page":"13","article-title":"Equipping the dental practice","author":"Bellows J","year":"2004","unstructured":"Bellows J. Equipping the dental practice. In: Bellows J, ed. Small Animal Dental Equipment, Materials, and Techniques: A Primer. Blackwell; 2004:13\u201355. doi:10.1002\/9780470344873.ch2"},{"key":"ref18","series-title":"Veterinary Dental Techniques","first-page":"175","article-title":"Dental prophylaxis and periodontal disease stages","author":"Holmstrolm SE","year":"2002","unstructured":"Holmstrolm SE, Frost P, Eisner ER. Dental prophylaxis and periodontal disease stages. In: Veterinary Dental Techniques. 3rd ed. Saunders; 2002:175\u2013232."},{"key":"ref19","series-title":"Veterinary Periodontology","first-page":"129","article-title":"The complete dental cleaning","author":"Niemiec BA","year":"2013","unstructured":"Niemiec BA. The complete dental cleaning. In: Niemiec BA, ed. Veterinary Periodontology. Wiley Blackwell; 2013:129\u2013153."},{"issue":"24","key":"ref20","series-title":"Tijdschr Diergeneeskd","first-page":"920","article-title":"Professional teeth cleaning is more than plaque removal. Professionele gebitsreiniging is wat anders dan tandsteen verwijderen. Rondbeltarieven of een verrichtingenlijst?","volume":"131","author":"van Foreest A","year":"2006","unstructured":"van Foreest A. Professional teeth cleaning is more than plaque removal. Professionele gebitsreiniging is wat anders dan tandsteen verwijderen. Rondbeltarieven of een verrichtingenlijst? Tijdschr Diergeneeskd. 2006;131(24):920-923."},{"issue":"12","key":"ref21","series-title":"Can Vet J","first-page":"1260","article-title":"Pilot evaluation of a novel test strip for the assessment of dissolved thiol levels, as an indicator of canine gingival health and periodontal status","volume":"53","author":"Manfra Marretta S","year":"2012","unstructured":"Manfra Marretta S, Leesman M, Burgess-Cassler A, McClure GD Jr, Buelow M, Finn M. Pilot evaluation of a novel test strip for the assessment of dissolved thiol levels, as an indicator of canine gingival health and periodontal status. Can Vet J. 2012;53(12):1260-1265."},{"issue":"3","key":"ref22","series-title":"J Am Anim Hosp Assoc","first-page":"132","article-title":"Oral-fluid thiol-detection test identifies underlying active periodontal disease not detected by the visual awake examination","volume":"54","author":"Queck KE","year":"2018","unstructured":"Queck KE, Chapman A, Herzog LJ, Shell-Martin T, Burgess-Cassler A, McClure GD. Oral-fluid thiol-detection test identifies underlying active periodontal disease not detected by the visual awake examination. J Am Anim Hosp Assoc. 2018;54(3):132-137. doi:10.5326\/JAAHA-MS-6607"},{"issue":"5","key":"ref23","series-title":"Gen Dent","first-page":"50","article-title":"Salivary thiol levels and periodontal parameters assessed with a chromogenic strip","volume":"61","author":"Khocht A","year":"2013","unstructured":"Khocht A, Seyedain M, Hardan S, Gaughan J, Suzuki JB. Salivary thiol levels and periodontal parameters assessed with a chromogenic strip. Gen Dent. 2013;61(5):50-54."},{"key":"ref24","article-title":"Package insert","author":"Orastrip DX thiol test","year":"2011","unstructured":"Orastrip DX thiol test. Package insert. PDX Biotech LLC; 2011."},{"key":"ref25","article-title":"Package insert","author":"Oravet","year":"2025","unstructured":"Oravet. Package insert. Boehringer Ingelheim; 2025."},{"issue":"9","key":"ref26","series-title":"J Am Vet Med Assoc","first-page":"1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"Lund EM","year":"1999","unstructured":"Lund EM, Armstrong PJ, Kirk CA, Kolar LM, Klausner JS. Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. J Am Vet Med Assoc. 1999;214(9):1336-1341. doi:10.2460\/javma.1999.214.09.1336"},{"issue":"4","key":"ref27","series-title":"Rev Ceres","first-page":"446","article-title":"Prevalence of periodontal disease in dogs and owners\u2019 level of awareness - a prospective clinical trial. Preval\u00eancia da doen\u00e7a periodontal em c\u00e3es e ci\u00eancia dos propriet\u00e1rios a respeito da doen\u00e7a","volume":"59","author":"Fernandes NA","year":"2012","unstructured":"Fernandes NA, Batista Borges AP, Carlo Reis EC, Sep\u00falveda RV, de Sousa Pontes KC. Prevalence of periodontal disease in dogs and owners\u2019 level of awareness - a prospective clinical trial. Preval\u00eancia da doen\u00e7a periodontal em c\u00e3es e ci\u00eancia dos propriet\u00e1rios a respeito da doen\u00e7a. Rev Ceres. 2012;59(4):446-451. doi:10.1590\/S0034-737X2012000400003"},{"issue":"4","key":"ref28","series-title":"Clin Tech Small Anim Pract","first-page":"243","article-title":"Oronasal fistula repair","volume":"15","author":"Smith MM","year":"2000","unstructured":"Smith MM. Oronasal fistula repair. Clin Tech Small Anim Pract. 2000;15(4):243-250. doi:10.1053\/svms.2000.21398"},{"issue":"5","key":"ref29","series-title":"Vet Clin North Am Small Anim Pract","first-page":"1285","article-title":"Maxillofacial surgery","volume":"28","author":"Marretta SM","year":"1998","unstructured":"Marretta SM. Maxillofacial surgery. Vet Clin North Am Small Anim Pract. 1998;28(5):1285-1296, viii. doi:10.1016\/S0195-5616(98)50114-3"},{"key":"ref30","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"199","article-title":"Problems with muscles, bones, and joints","author":"Taney KG","year":"2010","unstructured":"Taney KG, Smith MM. Problems with muscles, bones, and joints. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:199\u2013204. doi:10.1201\/b18171-9"},{"issue":"2","key":"ref31","series-title":"Top Companion Anim Med","first-page":"72","article-title":"Periodontal disease","volume":"23","author":"Niemiec BA","year":"2008","unstructured":"Niemiec BA. Periodontal disease. Top Companion Anim Med. 2008;23(2):72-80. doi:10.1053\/j.tcam.2008.02.003"},{"issue":"2","key":"ref32","series-title":"Orbit","first-page":"221","article-title":"Orbital cellulitis and osteomyelitis secondary to odontogenic infection with campylobacter rectus: a case report","volume":"42","author":"Goswami P","year":"2023","unstructured":"Goswami P, Ie A, O\u2019Donnell BA. Orbital cellulitis and osteomyelitis secondary to odontogenic infection with campylobacter rectus: a case report. Orbit. 2023;42(2):221-223. doi:10.1080\/01676830.2021.1990349"},{"issue":"3","key":"ref33","series-title":"J Am Anim Hosp Assoc","first-page":"215","article-title":"Ophthalmic manifestations and complications of dental disease in dogs and cats","volume":"32","author":"Ramsey DT","year":"1996","unstructured":"Ramsey DT, Marretta SM, Hamor RE, Ophthalmic manifestations and complications of dental disease in dogs and cats. J Am Anim Hosp Assoc. 1996;32(3):215-224. doi:10.5326\/15473317-32-3-215"},{"issue":"2","key":"ref34","series-title":"Vet Ophthalmol","first-page":"106","article-title":"Nasolacrimal obstruction caused by root abscess of the upper canine in a cat","volume":"13","author":"Anthony JM","year":"2010","unstructured":"Anthony JM, Sandmeyer LS, Laycock AR. Nasolacrimal obstruction caused by root abscess of the upper canine in a cat. Vet Ophthalmol. 2010;13(2):106-109. doi:10.1111\/j.1463-5224.2009.00754.x"},{"issue":"3","key":"ref35","series-title":"J Clin Diagn Res","first-page":"ZD08","article-title":"Resection and regeneration - a novel approach in treating a perio-endo lesion","volume":"9","author":"Varughese V","year":"2015","unstructured":"Varughese V, Mahendra J, Thomas AR, Ambalavanan N. Resection and regeneration - a novel approach in treating a perio-endo lesion. J Clin Diagn Res. 2015;9(3):ZD08-ZD10. doi:10.7860\/JCDR\/2015\/11096.5643"},{"key":"ref36","series-title":"Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook","first-page":"127","article-title":"Problems with the dental hard tissues","author":"DuPont GG","year":"2010","unstructured":"DuPont GG. Problems with the dental hard tissues. In: Niemiec BA, ed. Small Animal Dental, Oral and Maxillofacial Disease: A Color Handbook. Manson; 2010:127\u2013157. doi:10.1201\/b18171-6"},{"issue":"3","key":"ref37","series-title":"J Vet Dent","first-page":"160","article-title":"Successful treatment of mandibular nonunion with cortical allograft, cancellous autograft, and locking titanium miniplates in a dog","volume":"33","author":"Snyder CJ","year":"2016","unstructured":"Snyder CJ, Bleedorn JA, Soukup JW. Successful treatment of mandibular nonunion with cortical allograft, cancellous autograft, and locking titanium miniplates in a dog. J Vet Dent. 2016;33(3):160-169. doi:10.1177\/0898756416671060"},{"issue":"26","key":"ref38","series-title":"Oncotarget","first-page":"22613","article-title":"Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model","volume":"6","author":"Binder Gallimidi A","year":"2015","unstructured":"Binder Gallimidi A, Fischman S, Revach B, Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget. 2015;6(26):22613-22623. doi:10.18632\/oncotarget.4209"},{"issue":"3","key":"ref39","series-title":"Appl Microbiol Biotechnol","first-page":"1393","article-title":"The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma","volume":"103","author":"Chang C","year":"2019","unstructured":"Chang C, Geng F, Shi X, The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma. Appl Microbiol Biotechnol. 2019;103(3):1393-1404. doi:10.1007\/s00253-018-9475-6"},{"issue":"1","key":"ref40","series-title":"BMC Oral Health","first-page":"640","article-title":"Periodontitis as a risk for oral cancer: a case-control study","volume":"21","author":"Koml\u00f3s G","year":"2021","unstructured":"Koml\u00f3s G, Csurgay K, Horv\u00e1th F, Pelyhe L, N\u00e9meth Z. Periodontitis as a risk for oral cancer: a case-control study. BMC Oral Health. 2021;21(1):640. doi:10.1186\/s12903-021-01998-y"},{"issue":"2","key":"ref41","series-title":"J Vet Dent","first-page":"97","article-title":"Periodontal disease burden and pathological changes in organs of dogs","volume":"25","author":"Pavlica Z","year":"2008","unstructured":"Pavlica Z, Petelin M, Juntes P, Erzen D, Crossley DA, Skaleric U. Periodontal disease burden and pathological changes in organs of dogs. J Vet Dent. 2008;25(2):97-105. doi:10.1177\/089875640802500210"},{"issue":"2","key":"ref42","series-title":"J Vet Dent","first-page":"57","article-title":"Association of periodontal disease and histologic lesions in multiple organs from 45 dogs","volume":"13","author":"DeBowes LJ","year":"1996","unstructured":"DeBowes LJ, Mosier D, Logan E, Harvey CE, Lowry S, Richardson DC. Association of periodontal disease and histologic lesions in multiple organs from 45 dogs. J Vet Dent. 1996;13(2):57-60. doi:10.1177\/089875649601300201"},{"issue":"7","key":"ref43","series-title":"PLoS One","first-page":"e0255310","article-title":"The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats","volume":"16","author":"Hall JA","year":"2021","unstructured":"Hall JA, Forman FJ, Bobe G, Farace G, Yerramilli M. The impact of periodontal disease and dental cleaning procedures on serum and urine kidney biomarkers in dogs and cats. PLoS One. 2021;16(7):e0255310. doi:10.1371\/journal.pone.0255310"},{"issue":"4","key":"ref44","series-title":"J Am Vet Med Assoc","first-page":"486","article-title":"Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs","volume":"234","author":"Glickman LT","year":"2009","unstructured":"Glickman LT, Glickman NW, Moore GE, Goldstein GS, Lewis HB. Evaluation of the risk of endocarditis and other cardiovascular events on the basis of the severity of periodontal disease in dogs. J Am Vet Med Assoc. 2009;234(4):486-494. doi:10.2460\/javma.234.4.486"},{"issue":"4","key":"ref45","series-title":"J Vet Intern Med","first-page":"216","article-title":"Cholestasis associated with extrahepatic bacterial infection in five dogs","volume":"3","author":"Taboada J","year":"1989","unstructured":"Taboada J, Meyer DJ. Cholestasis associated with extrahepatic bacterial infection in five dogs. J Vet Intern Med. 1989;3(4):216-221. doi:10.1111\/j.1939-1676.1989.tb00860.x"},{"issue":"2","key":"ref46","series-title":"Open Vet J","first-page":"210","article-title":"Periodontal disease is associated with cognitive dysfunction in aging dogs: a blinded prospective comparison of visual periodontal and cognitive questionnaire scores","volume":"11","author":"Dewey CW","year":"2021","unstructured":"Dewey CW, Rishniw M. Periodontal disease is associated with cognitive dysfunction in aging dogs: a blinded prospective comparison of visual periodontal and cognitive questionnaire scores. Open Vet J. 2021;11(2):210-216. doi:10.5455\/OVJ.2021.v11.i2.4"},{"issue":"3","key":"ref47","series-title":"Vet Sci","first-page":"99","article-title":"Correlation between oxidative stress markers and periodontal disease in dogs","volume":"11","author":"Pe\u0219tean CP","year":"2024","unstructured":"Pe\u0219tean CP, Pocquet H, Dumitra\u0219 DA, Morohoschi AG, \u015etef\u0103nu\u0163 LC, Andrei S. Correlation between oxidative stress markers and periodontal disease in dogs. Vet Sci. 2024;11(3):99-103. doi:10.3390\/vetsci11030099"},{"issue":"1","key":"ref48","series-title":"BMC Oral Health","first-page":"266","article-title":"Correlation between whole salivary prostaglandin E2 and hemoglobin A1c levels among type-2 diabetic and non-diabetic patients with periodontal inflammation","volume":"24","author":"Shaheen MY","year":"2024","unstructured":"Shaheen MY, Basudan AM, Alzawawi AS, Correlation between whole salivary prostaglandin E2 and hemoglobin A1c levels among type-2 diabetic and non-diabetic patients with periodontal inflammation. BMC Oral Health. 2024;24(1):266. doi:10.1186\/s12903-024-04032-z"},{"issue":"10","key":"ref49","series-title":"J Dent Res","first-page":"962","article-title":"Association between periodontal diseases and the risk of site-specific gastrointestinal cancers: a systematic review and meta-analysis","volume":"103","author":"Wang Q","year":"2024","unstructured":"Wang Q, Gu WJ, Ning FL, Association between periodontal diseases and the risk of site-specific gastrointestinal cancers: a systematic review and meta-analysis. J Dent Res. 2024;103(10):962-972. doi:10.1177\/00220345241263768"},{"issue":"7","key":"ref50","series-title":"J Am Geriatr Soc","first-page":"1206","article-title":"Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up","volume":"57","author":"Avlund K","year":"2009","unstructured":"Avlund K, Schultz-Larsen K, Krustrup U, Christiansen N, Holm-Pedersen P. Effect of inflammation in the periodontium in early old age on mortality at 21-year follow-up. J Am Geriatr Soc. 2009;57(7):1206-1212. doi:10.1111\/j.1532-5415.2009.02328.x"},{"issue":"2","key":"ref51","series-title":"J Am Anim Hosp Assoc","first-page":"49","article-title":"2019 AAHA dental care guidelines for dogs and cats","volume":"55","author":"Bellows J","year":"2019","unstructured":"Bellows J, Berg ML, Dennis S, 2019 AAHA dental care guidelines for dogs and cats. 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