{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:05:21Z","timestamp":1774321521529,"version":"3.50.1"},"reference-count":80,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the clinical outcomes of 10 cats diagnosed with CNS lymphoma treated with lomustine and corticosteroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Clinical records of privately owned cats diagnosed with CNS lymphoma and presented to a neurological veterinary center were reviewed. Inclusion criteria were MRI, CSF analysis, treatment with corticosteroids and lomustine, and availability of detailed follow-up data. Cats with incomplete data, alternative diagnoses, or concomitant intracranial conditions as well as those improving after corticosteroid treatment before the diagnosis were excluded. Ten cats met the inclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Presentation<\/jats:title>\n                    <jats:p>The median duration of clinical signs was 7 days. All patients presented with locomotor deficits; 90% exhibited ataxia. Paresis was observed in 60%, and spinal pain on palpation was also described in 60% of the cats. Cranial nerve abnormalities were identified in 30% and epileptic seizures were reported in 20% of the cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MRI revealed intracranial lymphoma in 40% and spinal lymphoma in 60% of the cases and contrast-enhancing lesions with meningeal involvement in most of the cases. One cat had elevated CSF cell counts; the others showed normal cell counts but atypical lymphocytes. Seven cats (70%) were still alive at the 3-month follow-up, with 3 (30%) maintaining improvement at 6 and 12 months. The treatment did not result in any significant adverse effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>The combination of lomustine and corticosteroids is a valid chemotherapeutic option in cats with CNS lymphoma. Larger prospective studies are warranted to compare efficacy of this treatment with that of other chemotherapeutic protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.25.07.0486","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:39:32Z","timestamp":1760121572000},"page":"211-217","source":"Crossref","is-referenced-by-count":1,"title":["The combination of lomustine and corticosteroids is a valid chemotherapeutic option in cats with presumptive central nervous system lymphoma"],"prefix":"10.2460","volume":"264","author":[{"given":"Claudia","family":"Pauciulo","sequence":"first","affiliation":[{"name":"Veterinary Neurology Center, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9771-4143","authenticated-orcid":true,"given":"Andrea","family":"Corda","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Teaching Hospital, University of Sassari, Sassari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilaria","family":"Tartari","sequence":"additional","affiliation":[{"name":"Veterinary Neurological Center \u201cLa Fenice,\u201d Selargius, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Tocco","sequence":"additional","affiliation":[{"name":"Veterinary Neurological Center \u201cLa Fenice,\u201d Selargius, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa","family":"Murgia","sequence":"additional","affiliation":[{"name":"Veterinary Neurological Center \u201cLa Fenice,\u201d Selargius, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Gallucci","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Veterinary Teaching Hospital, University of Sassari, Sassari, Italy"},{"name":"Veterinary Neurological Center \u201cLa Fenice,\u201d Selargius, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"1","key":"ref1","series-title":"Vet Comp Oncol","first-page":"38","article-title":"Histopathologic classification of 171 cases of canine and feline non-Hodgkin lymphoma according to the WHO","volume":"8","author":"Vezzali E","year":"2010","unstructured":"Vezzali E, Parodi AL, Marcato PS, Bettini G. 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