{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:08:48Z","timestamp":1788541728550,"version":"build-2803163510"},"reference-count":80,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine disease progression and survival duration in cats diagnosed with early-stage chronic kidney disease (CKD) continuously treated with a veterinary therapeutic renal diet versus those untreated at diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study utilized a commercial database of medical records from veterinary practices located in Canada and the US. Cats born between January 1, 2010, and December 31, 2014, diagnosed with early-stage CKD were randomly selected. Records were reviewed to determine the date of diagnosis and whether treatment with a therapeutic renal diet was initiated. Progression of CKD and survival duration were evaluated with longitudinal targeted maximum likelihood estimation modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1,430 cats with early CKD, 839 received a veterinary therapeutic renal diet and 591 did not. Dietary therapy was associated with reduced risk of progression. Treated CKD Stage 1 cats had a 45% lower hazard of progression (hazard ratio [HR], 0.55; 95% CI, 0.52 to 0.58). Treated CKD Stage 2 cats that had creatinine within and above the reference intervals had 46% (HR, 0.54; 95% CI, 0.50 to 0.58) and 41% (HR, 0.59; 95% CI, 0.56 to 0.62) lower hazards of progression, respectively. Cats treated with a therapeutic renal diet had a longer survival over 3 years: restricted mean survival time was 31.0 versus 26.0 months in untreated cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Use of a veterinary therapeutic renal diet in cats with early CKD slows disease progression and improves survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Early diagnosis and intervention with a therapeutic renal diet may optimize long-term outcomes in cats with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.25.10.0665","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:38:38Z","timestamp":1768408718000},"page":"590-598","source":"Crossref","is-referenced-by-count":2,"title":["Use of a veterinary therapeutic renal diet in cats with early chronic kidney disease is associated with slower disease progression and improved survival"],"prefix":"10.2460","volume":"264","author":[{"given":"Michael","family":"Coyne","sequence":"first","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Szlosek","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Webeck","sequence":"additional","affiliation":[{"name":"Independent Contractor, Flat Rock, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhaysa","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Independent Contractor, Winter Garden, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"Berger","sequence":"additional","affiliation":[{"name":"Veterinary Center at Fishhawk, Lithia, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Doukas","sequence":"additional","affiliation":[{"name":"Gaston College, Dallas, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Denton","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalee","family":"Holt","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Michael","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"O\u2019Kell","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Riggott","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Sweet","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"McCrann","sequence":"additional","affiliation":[{"name":"Idexx Laboratories Inc, Westbrook, ME"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"2","key":"ref1","series-title":"J Feline Med Surg.","first-page":"125","article-title":"Longevity and mortality of cats attending primary care veterinary practices in England","volume":"17","author":"O\u2019Neill DG","year":"2015","unstructured":"O\u2019Neill DG, Church DB, McGreevy PD, Thomson PC, Brodbelt DC. 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