{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:55:15Z","timestamp":1781718915166,"version":"3.54.5"},"reference-count":96,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to evaluate the diagnostic and prognostic utility of RBC distribution width (RDW) for gastrointestinal lymphoma (GIL) versus chronic inflammatory enteropathy (CIE) in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records of dogs diagnosed with GIL or CIE based on histopathological examination of endoscopic gastrointestinal biopsy specimens between April 1, 2016, and March 31, 2024, were retrospectively reviewed. Red blood cell parameters were measured at diagnosis via an automated hematology analyzer (ProCyte Dx; Idexx Laboratories Inc). Canine Chronic Enteropathy Clinical Activity Index (CCECAI) score was recorded. The diagnostic performance of RDW and CCECAI was assessed with logistic regression and receiver operating characteristic curve analyses. The prognostic value was evaluated via Kaplan-Meier survival analysis and Cox proportional hazards modeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>56 dogs were diagnosed with GIL, and 60 were diagnosed with CIE. The RDW was significantly higher in the GIL group compared to the CIE group, with an area under the curve of 0.63. In logistic regression analysis, RDW (OR, 1.25) and CCECAI (OR, 1.27) were identified as independent predictors of GIL versus CIE. Kaplan-Meier survival analysis for GIL showed that the median overall survival time (OST) was significantly shorter for dogs with RDW &gt; 18.3% (134 days). In the multivariable Cox proportional hazards analysis, RDW remained an independent prognostic factor for OST for GIL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RDW was independently associated with a diagnosis of GIL and with shorter OST in dogs with GIL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>RDW may provide information when considering endoscopic biopsy and prognosis in dogs with suspected GIL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.25.10.0684","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T17:22:33Z","timestamp":1773854553000},"page":"882-891","source":"Crossref","is-referenced-by-count":0,"title":["Red blood cell distribution width may help distinguish canine gastrointestinal lymphoma from chronic inflammatory enteropathy and be a prognostic indicator"],"prefix":"10.2460","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6835-6273","authenticated-orcid":true,"given":"Kosuke","family":"Horita","sequence":"first","affiliation":[{"name":"Veterinary Medical Center, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Fukuoka","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aki","family":"Ohmi","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Tomiyasu","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4690-8244","authenticated-orcid":true,"given":"Masaru","family":"Okuda","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Internal Medicine, Department of Veterinary Medical Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Withrow and MacEwen\u2019s Small Animal Clinical Oncology","first-page":"688","article-title":"Hematopoietic tumors","author":"Vail DM","year":"2019","unstructured":"Vail DM, Thamm DH, Liptak JM. Hematopoietic tumors. In: Withrow and MacEwen\u2019s Small Animal Clinical Oncology. Elsevier; 2019:688\u2013772. doi:10.1016\/B978-0-323-59496-7.00033-5"},{"issue":"4","key":"ref2","series-title":"Vet Pathol.","first-page":"668","article-title":"Distinguishing intestinal lymphoma from inflammatory bowel disease in canine duodenal endoscopic biopsy samples","volume":"52","author":"Carrasco V","year":"2015","unstructured":"Carrasco V, Rodr\u00edguez-Bertos A, Rodr\u00edguez-Franco F,  Distinguishing intestinal lymphoma from inflammatory bowel disease in canine duodenal endoscopic biopsy samples. Vet Pathol. 2015;52(4):668-675. doi:10.1177\/0300985814559398"},{"key":"ref3","series-title":"Vet J.","first-page":"296","article-title":"Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma","author":"Nakashima K","year":"2023","unstructured":"Nakashima K, Matsumoto I, Goto-Koshino Y,  Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma. Vet J. 2023;296-297:105993. doi:10.1016\/j.tvjl.2023.105993"},{"issue":"1","key":"ref4","series-title":"Vet Comp Oncol.","first-page":"102","article-title":"Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin","volume":"20","author":"Nakagawa T","year":"2022","unstructured":"Nakagawa T, Kojima M, Ohno K,  Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin. Vet Comp Oncol. 2022;20(1):102-108. doi:10.1111\/vco.12749"},{"issue":"3","key":"ref5","series-title":"J Small Anim Pract.","first-page":"147","article-title":"Low-grade gastrointestinal lymphoma in dogs: 20 cases (2010 to 2016)","volume":"59","author":"Lane J","year":"2018","unstructured":"Lane J, Price J, Moore A,  Low-grade gastrointestinal lymphoma in dogs: 20 cases (2010 to 2016). J Small Anim Pract. 2018;59(3):147-153. doi:10.1111\/jsap.12769"},{"key":"ref6","series-title":"Front Vet Sci.","first-page":"923013","article-title":"Canine chronic enteropathy\u2014current state-of-the-art and emerging concepts","volume":"9","author":"Jergens AE","year":"2022","unstructured":"Jergens AE, Heilmann RM. Canine chronic enteropathy\u2014current state-of-the-art and emerging concepts. Front Vet Sci. 2022;9:923013. doi:10.3389\/fvets.2022.923013"},{"issue":"5","key":"ref7","series-title":"Animals (Basel).","first-page":"681","article-title":"Updating the classification of chronic inflammatory enteropathies in dogs","volume":"14","author":"Dupouy-Manescau N","year":"2024","unstructured":"Dupouy-Manescau N, M\u00e9ric T, S\u00e9n\u00e9cat O,  Updating the classification of chronic inflammatory enteropathies in dogs. Animals (Basel). 2024;14(5):681. doi:10.3390\/ani14050681"},{"issue":"4","key":"ref8","series-title":"Vet Pathol.","first-page":"595","article-title":"Endoscopic cytology for the diagnosis of chronic enteritis and intestinal lymphoma in dogs","volume":"54","author":"Maeda S","year":"2017","unstructured":"Maeda S, Tsuboi M, Sakai K,  Endoscopic cytology for the diagnosis of chronic enteritis and intestinal lymphoma in dogs. Vet Pathol. 2017;54(4):595-604. doi:10.1177\/0300985817705175"},{"key":"ref9","series-title":"Ettinger\u2019s Textbook of Veterinary Internal Medicine","author":"Ettinger SJ","year":"2024","unstructured":"Ettinger SJ, Feldman EC, Cote E, eds. Ettinger\u2019s Textbook of Veterinary Internal Medicine. 9th ed. Elsevier; 2024."},{"issue":"1","key":"ref10","series-title":"J Small Anim Pract","first-page":"32","article-title":"How useful is abdominal ultrasonography in dogs with diarrhoea?","volume":"59","author":"Mapletoft EK","year":"2018","unstructured":"Mapletoft EK, Allenspach K, Lamb CR. How useful is abdominal ultrasonography in dogs with diarrhoea? J Small Anim Pract. 2018;59(1):32-37. doi:10.1111\/jsap.12780"},{"issue":"4","key":"ref11","series-title":"J Am Vet Med Assoc.","first-page":"487","article-title":"Retrospective evaluation of anemia and erythrocyte morphological anomalies in dogs with lymphoma or inflammatory bowel disease","volume":"254","author":"Parachini-Winter C","year":"2019","unstructured":"Parachini-Winter C, Carioto LM, Gara-Boivin C. Retrospective evaluation of anemia and erythrocyte morphological anomalies in dogs with lymphoma or inflammatory bowel disease. J Am Vet Med Assoc. 2019;254(4):487-495. doi:10.2460\/javma.254.4.487"},{"issue":"6","key":"ref12","series-title":"Animals (Basel).","first-page":"837","article-title":"Monocytes count, NLR, MLR and PLR in canine inflammatory bowel disease","volume":"14","author":"Marchesi MC","year":"2024","unstructured":"Marchesi MC, Maggi G, Cremonini V,  Monocytes count, NLR, MLR and PLR in canine inflammatory bowel disease. Animals (Basel). 2024;14(6):837. doi:10.3390\/ani14060837"},{"issue":"6","key":"ref13","series-title":"Animals (Basel).","first-page":"985","article-title":"Red blood cell distribution width as a novel parameter in canine disorders: literature review and future prospective","volume":"13","author":"Miglio A","year":"2023","unstructured":"Miglio A, Valente C, Guglielmini C. Red blood cell distribution width as a novel parameter in canine disorders: literature review and future prospective. Animals (Basel). 2023;13(6):985. doi:10.3390\/ani13060985"},{"issue":"1","key":"ref14","series-title":"Indian J Crit Care Med.","first-page":"49","article-title":"Red cell distribution width as a novel prognostic marker in multiple clinical studies","volume":"24","author":"Yousefi B","year":"2020","unstructured":"Yousefi B, Sanaie S, Ghamari AA, Soleimanpour H, Karimian A, Mahmoodpoor A. Red cell distribution width as a novel prognostic marker in multiple clinical studies. Indian J Crit Care Med. 2020;24(1):49-54. doi:10.5005\/jp-journals-10071-23328"},{"issue":"9","key":"ref15","series-title":"Oncotarget.","first-page":"16027","article-title":"Prognostic value of RDW in cancers: a systematic review and meta-analysis","volume":"8","author":"Hu L","year":"2017","unstructured":"Hu L, Li M, Ding Y,  Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget. 2017;8(9):16027-16035. doi:10.18632\/oncotarget.13784"},{"issue":"9","key":"ref16","series-title":"Can Vet J.","first-page":"964","article-title":"Evaluation of red blood cell distribution width in dogs with various illnesses","volume":"60","author":"Martinez C","year":"2019","unstructured":"Martinez C, Mooney CT, Shiel RE, Tang PK, Mooney L, O\u2019Neill EJ. Evaluation of red blood cell distribution width in dogs with various illnesses. Can Vet J. 2019;60(9):964-971."},{"key":"ref17","series-title":"Front Vet Sci.","first-page":"1258857","article-title":"Comparison of visual assessments of anisocytosis in canine blood smears and analyzer-calculated red blood cell distribution width","volume":"10","author":"Jensen AL","year":"2023","unstructured":"Jensen AL, Krogh AKH, Nielsen LN. Comparison of visual assessments of anisocytosis in canine blood smears and analyzer-calculated red blood cell distribution width. Front Vet Sci. 2023;10:1258857. doi:10.3389\/fvets.2023.1258857"},{"issue":"4","key":"ref18","series-title":"Acta Vet Brno.","first-page":"385","article-title":"Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido","volume":"86","author":"Anio\u0142ek O","year":"2017","unstructured":"Anio\u0142ek O, Barc A, Jarosi\u0144ska A, Gajewski Z. Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido. Acta Vet Brno. 2017;86(4):385-391. doi:10.2754\/avb201786040385"},{"issue":"3","key":"ref19","series-title":"J Comp Pathol.","first-page":"269","article-title":"Investigations of bone marrow dyscrasia in a Poodle with macrocytosis","volume":"101","author":"Canfield PJ","year":"1989","unstructured":"Canfield PJ, Watson AD. Investigations of bone marrow dyscrasia in a Poodle with macrocytosis. J Comp Pathol. 1989;101(3):269-278. doi:10.1016\/0021-9975(89)90036-4"},{"issue":"3","key":"ref20","series-title":"Thromb Res.","first-page":"334","article-title":"Red cell distribution width and risk for venous thromboembolism: a population-based cohort study","volume":"133","author":"Z\u00f6ller B","year":"2014","unstructured":"Z\u00f6ller B, Melander O, Svensson P, Engstr\u00f6m G. Red cell distribution width and risk for venous thromboembolism: a population-based cohort study. Thromb Res. 2014;133(3):334-339. doi:10.1016\/j.thromres.2013.12.013"},{"issue":"2","key":"ref21","series-title":"Top Companion Anim Med.","first-page":"59","article-title":"Diseases associated with thrombosis","volume":"27","author":"de Laforcade A","year":"2012","unstructured":"de Laforcade A. Diseases associated with thrombosis. Top Companion Anim Med. 2012;27(2):59-64. doi:10.1053\/j.tcam.2012.07.002"},{"issue":"2","key":"ref22","series-title":"Vet Pathol.","first-page":"227","article-title":"Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples","volume":"59","author":"Kojima K","year":"2022","unstructured":"Kojima K, Chambers JK, Nakashima K, Goto-Koshino Y, Uchida K. Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples. Vet Pathol. 2022;59(2):227-235. doi:10.1177\/03009858211057220"},{"issue":"suppl 1","key":"ref23","series-title":"J Comp Pathol.","first-page":"S1","article-title":"World Small Animal Veterinary Association Gastrointestinal Standardization Group. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group","volume":"138","author":"Day MJ","year":"2008","unstructured":"Day MJ, Bilzer T, Mansell J, ; World Small Animal Veterinary Association Gastrointestinal Standardization Group. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol. 2008;138(suppl 1):S1-S43. doi:10.1016\/j.jcpa.2008.01.001"},{"key":"ref24","series-title":"Interpreting IDEXX ProCyte Dx Hematology Analyzer Dot Plots","author":"Idexx","year":"2023","unstructured":"Idexx. Interpreting IDEXX ProCyte Dx Hematology Analyzer Dot Plots. Idexx Laboratories Inc; 2023. Accessed March 11, 2026. https:\/\/www.idexx.com\/files\/dot-plot-procyte-dx-en.pdf"},{"issue":"8","key":"ref25","series-title":"J Small Anim Pract.","first-page":"603","article-title":"Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it","volume":"63","author":"Bergstrand E","year":"2022","unstructured":"Bergstrand E, Tvedten HW, Lillieh\u00f6\u00f6k I. Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it. J Small Anim Pract. 2022;63(8):603-608. doi:10.1111\/jsap.13499"},{"issue":"3","key":"ref26","series-title":"J Vet Intern Med.","first-page":"291","article-title":"A scoring index for disease activity in canine inflammatory bowel disease","volume":"17","author":"Jergens AE","year":"2003","unstructured":"Jergens AE, Schreiner CA, Frank DE,  A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med. 2003;17(3):291-297. doi:10.1111\/j.1939-1676.2003.tb02450.x"},{"issue":"4","key":"ref27","series-title":"J Vet Intern Med.","first-page":"700","article-title":"Chronic enteropathies in dogs: evaluation of risk factors for negative outcome","volume":"21","author":"Allenspach K","year":"2007","unstructured":"Allenspach K, Wieland B, Gr\u00f6ne A, Gaschen F. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med. 2007;21(4):700-708. doi:10.1111\/j.1939-1676.2007.tb03011.x"},{"issue":"3","key":"ref28","series-title":"Bone Marrow Transplant.","first-page":"452","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48(3):452-458. doi:10.1038\/bmt.2012.244"},{"issue":"5","key":"ref29","series-title":"J Vet Intern Med","first-page":"732","article-title":"Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma?","volume":"19","author":"MacDonald VS","year":"2005","unstructured":"MacDonald VS, Thamm DH, Kurzman ID, Turek MM, Vail DM. Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma? J Vet Intern Med. 2005;19(5):732-736. doi:10.1111\/j.1939-1676.2005.tb02753.x"},{"issue":"3","key":"ref30","series-title":"Vet Clin Pathol.","first-page":"259","article-title":"Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma","volume":"34","author":"Marchetti V","year":"2005","unstructured":"Marchetti V, Benetti C, Citi S, Taccini V. Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol. 2005;34(3):259-263. doi:10.1111\/j.1939-165X.2005.tb00051.x"},{"issue":"7","key":"ref31","series-title":"Rev Med Vet (Toulouse).","first-page":"549","article-title":"Red blood cell distribution width (RDW) in the dog: a retrospective study of 1400 cases","volume":"152","author":"Perret D","year":"2001","unstructured":"Perret D, Trumel C, Diqu\u00e9lou A, Dossin O, Guelfi J, Espie C. Red blood cell distribution width (RDW) in the dog: a retrospective study of 1400 cases. Rev Med Vet (Toulouse). 2001;152(7):549-554."},{"issue":"3","key":"ref32","series-title":"Can Vet J.","first-page":"250","article-title":"Iron deficiency anemia","volume":"53","author":"Naigamwalla DZ","year":"2012","unstructured":"Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53(3):250-256."},{"issue":"8","key":"ref33","series-title":"Vet Sci.","first-page":"751","article-title":"Clinicopathological and endoscopic features of diffuse alimentary lymphoma in 18 dogs","volume":"12","author":"Bedel F","year":"2025","unstructured":"Bedel F, Betting A, Girod M,  Clinicopathological and endoscopic features of diffuse alimentary lymphoma in 18 dogs. Vet Sci. 2025;12(8):751. doi:10.3390\/vetsci12080751"},{"key":"ref34","series-title":"Small Animal Critical Care Medicine","first-page":"630","article-title":"Gastrointestinal hemorrhage","author":"Boysen SR","year":"2015","unstructured":"Boysen SR. Gastrointestinal hemorrhage. In: Small Animal Critical Care Medicine. Elsevier; 2015:630\u2013634. doi:10.1016\/B978-1-4557-0306-7.00119-7"},{"issue":"6","key":"ref35","series-title":"J Vet Intern Med.","first-page":"2618","article-title":"Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: a double-blind randomized trial","volume":"33","author":"Whittemore JC","year":"2019","unstructured":"Whittemore JC, Mooney AP, Price JM, Thomason J. Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: a double-blind randomized trial. J Vet Intern Med. 2019;33(6):2618-2627. doi:10.1111\/jvim.15630"},{"issue":"9","key":"ref36","series-title":"Animals (Basel).","first-page":"2580","article-title":"Detection of anti-erythrocyte antibodies in dogs with inflammatory bowel disease (IBD)","volume":"11","author":"Gori E","year":"2021","unstructured":"Gori E, Pierini A, Nesci M,  Detection of anti-erythrocyte antibodies in dogs with inflammatory bowel disease (IBD). Animals (Basel). 2021;11(9):2580. doi:10.3390\/ani11092580"},{"issue":"11","key":"ref37","series-title":"Cureus.","first-page":"e74229","article-title":"The correlation of red cell distribution width with peripheral blood smear: a study from a tertiary care hospital in Peshawar","volume":"16","author":"Abbas S","year":"2024","unstructured":"Abbas S, Shah MM, Iftikhar M. The correlation of red cell distribution width with peripheral blood smear: a study from a tertiary care hospital in Peshawar. Cureus. 2024;16(11):e74229. doi:10.7759\/cureus.74229"},{"issue":"2","key":"ref38","series-title":"J Vet Res (Pulawy).","first-page":"325","article-title":"Analysis of red blood cell parameters in dogs with various stages of degenerative mitral valve disease","volume":"64","author":"Kumiega E","year":"2020","unstructured":"Kumiega E, Micha\u0142ek M, Kasztura M, Noszczyk-Nowak A. Analysis of red blood cell parameters in dogs with various stages of degenerative mitral valve disease. J Vet Res (Pulawy). 2020;64(2):325-332. doi:10.2478\/jvetres-2020-0043"},{"issue":"1","key":"ref39","series-title":"Vet Pathol.","first-page":"50","article-title":"Immunohistochemical profiling of canine intestinal T-Cell lymphomas","volume":"56","author":"Matsumoto I","year":"2019","unstructured":"Matsumoto I, Nakashima K, Goto-Koshino Y,  Immunohistochemical profiling of canine intestinal T-Cell lymphomas. Vet Pathol. 2019;56(1):50-60. doi:10.1177\/0300985818800015"},{"issue":"7","key":"ref40","series-title":"Leuk Lymphoma.","first-page":"1225","article-title":"The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study","volume":"64","author":"Castro D","year":"2023","unstructured":"Castro D, Valcarcel B, Runciman T,  The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study. Leuk Lymphoma. 2023;64(7):1225-1233. doi:10.1080\/10428194.2023.2205975"},{"issue":"4","key":"ref41","series-title":"Croat Med J.","first-page":"334","article-title":"Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study","volume":"56","author":"Peri\u0161a V","year":"2015","unstructured":"Peri\u0161a V, Zibar L, Sin\u010di\u0107-Petri\u010devi\u0107 J, Knezovi\u0107 A, Peri\u0161a I, Barbi\u0107 J. Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study. Croat Med J. 2015;56(4):334-343. doi:10.3325\/cmj.2015.56.334"},{"issue":"3","key":"ref42","series-title":"Animals (Basel).","first-page":"778","article-title":"Red cell distribution width has a negative prognostic role in dogs with myxomatous mitral valve disease","volume":"11","author":"Guglielmini C","year":"2021","unstructured":"Guglielmini C, Valentini CM, Contiero B, Valente C, Poser H. Red cell distribution width has a negative prognostic role in dogs with myxomatous mitral valve disease. Animals (Basel). 2021;11(3):778. doi:10.3390\/ani11030778"},{"issue":"24","key":"ref43","series-title":"Animals (Basel).","first-page":"3483","article-title":"Prognostic role of red cell distribution width and other routine clinico-pathological parameters in dogs with acute pancreatitis","volume":"12","author":"Guglielmini C","year":"2022","unstructured":"Guglielmini C, Crisi PE, Tardo AM,  Prognostic role of red cell distribution width and other routine clinico-pathological parameters in dogs with acute pancreatitis. Animals (Basel). 2022;12(24):3483. doi:10.3390\/ani12243483"},{"issue":"1","key":"ref44","series-title":"J Vet Emerg Crit Care (San Antonio).","first-page":"9","article-title":"Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs","volume":"32","author":"Ludwik TM","year":"2022","unstructured":"Ludwik TM, Heinrich DA, Rendahl A, Friedenberg SG. Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs. J Vet Emerg Crit Care (San Antonio). 2022;32(1):9-17. doi:10.1111\/vec.13109"},{"issue":"4","key":"ref45","series-title":"Open Vet J.","first-page":"980","article-title":"Hematological ratios and indices in canine large B-cell lymphoma","volume":"14","author":"Gavazza A","year":"2024","unstructured":"Gavazza A, Cremonini V, Miglio A, Starita C, Rossi G, Antognoni MT. Hematological ratios and indices in canine large B-cell lymphoma. Open Vet J. 2024;14(4):980-989. doi:10.5455\/OVJ.2024.v14.i4.5"},{"key":"ref46","series-title":"Vet Immunol Immunopathol.","first-page":"106","article-title":"Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs","volume":"182","author":"Calvalido J","year":"2016","unstructured":"Calvalido J, Wood GA, Mutsaers AJ, Wood D, Sears W, Woods JP. Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs. Vet Immunol Immunopathol. 2016;182:106-114. doi:10.1016\/j.vetimm.2016.10.009"},{"issue":"3","key":"ref47","series-title":"Vet Comp Oncol.","first-page":"337","article-title":"Clinical characteristics and outcome in dogs with small cell T-cell intestinal lymphoma","volume":"16","author":"Couto KM","year":"2018","unstructured":"Couto KM, Moore PF, Zwingenberger AL, Willcox JL, Skorupski KA. Clinical characteristics and outcome in dogs with small cell T-cell intestinal lymphoma. Vet Comp Oncol. 2018;16(3):337-343. doi:10.1111\/vco.12384"},{"issue":"2","key":"ref48","series-title":"J Vet Intern Med.","first-page":"317","article-title":"Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs","volume":"23","author":"Rassnick KM","year":"2009","unstructured":"Rassnick KM, Moore AS, Collister KE,  Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs. J Vet Intern Med. 2009;23(2):317-322. doi:10.1111\/j.1939-1676.2008.0270.x"},{"key":"ref1","series-title":"Withrow and MacEwen\u2019s Small Animal Clinical Oncology","first-page":"688","article-title":"Hematopoietic tumors","author":"Vail DM","year":"2019","unstructured":"Vail DM, Thamm DH, Liptak JM. Hematopoietic tumors. In: Withrow and MacEwen\u2019s Small Animal Clinical Oncology. Elsevier; 2019:688\u2013772. doi:10.1016\/B978-0-323-59496-7.00033-5"},{"issue":"4","key":"ref2","series-title":"Vet Pathol.","first-page":"668","article-title":"Distinguishing intestinal lymphoma from inflammatory bowel disease in canine duodenal endoscopic biopsy samples","volume":"52","author":"Carrasco V","year":"2015","unstructured":"Carrasco V, Rodr\u00edguez-Bertos A, Rodr\u00edguez-Franco F,  Distinguishing intestinal lymphoma from inflammatory bowel disease in canine duodenal endoscopic biopsy samples. Vet Pathol. 2015;52(4):668-675. doi:10.1177\/0300985814559398"},{"key":"ref3","series-title":"Vet J.","first-page":"296","article-title":"Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma","author":"Nakashima K","year":"2023","unstructured":"Nakashima K, Matsumoto I, Goto-Koshino Y,  Prognostic value of increased intraepithelial lymphocytes and lymphocytic clonality in dogs with chronic enteropathy or small-cell lymphoma. Vet J. 2023;296-297:105993. doi:10.1016\/j.tvjl.2023.105993"},{"issue":"1","key":"ref4","series-title":"Vet Comp Oncol.","first-page":"102","article-title":"Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin","volume":"20","author":"Nakagawa T","year":"2022","unstructured":"Nakagawa T, Kojima M, Ohno K,  Efficacy and adverse events of continuous l-asparaginase administration for canine large cell lymphoma of presumed gastrointestinal origin. Vet Comp Oncol. 2022;20(1):102-108. doi:10.1111\/vco.12749"},{"issue":"3","key":"ref5","series-title":"J Small Anim Pract.","first-page":"147","article-title":"Low-grade gastrointestinal lymphoma in dogs: 20 cases (2010 to 2016)","volume":"59","author":"Lane J","year":"2018","unstructured":"Lane J, Price J, Moore A,  Low-grade gastrointestinal lymphoma in dogs: 20 cases (2010 to 2016). J Small Anim Pract. 2018;59(3):147-153. doi:10.1111\/jsap.12769"},{"key":"ref6","series-title":"Front Vet Sci.","first-page":"923013","article-title":"Canine chronic enteropathy\u2014current state-of-the-art and emerging concepts","volume":"9","author":"Jergens AE","year":"2022","unstructured":"Jergens AE, Heilmann RM. Canine chronic enteropathy\u2014current state-of-the-art and emerging concepts. Front Vet Sci. 2022;9:923013. doi:10.3389\/fvets.2022.923013"},{"issue":"5","key":"ref7","series-title":"Animals (Basel).","first-page":"681","article-title":"Updating the classification of chronic inflammatory enteropathies in dogs","volume":"14","author":"Dupouy-Manescau N","year":"2024","unstructured":"Dupouy-Manescau N, M\u00e9ric T, S\u00e9n\u00e9cat O,  Updating the classification of chronic inflammatory enteropathies in dogs. Animals (Basel). 2024;14(5):681. doi:10.3390\/ani14050681"},{"issue":"4","key":"ref8","series-title":"Vet Pathol.","first-page":"595","article-title":"Endoscopic cytology for the diagnosis of chronic enteritis and intestinal lymphoma in dogs","volume":"54","author":"Maeda S","year":"2017","unstructured":"Maeda S, Tsuboi M, Sakai K,  Endoscopic cytology for the diagnosis of chronic enteritis and intestinal lymphoma in dogs. Vet Pathol. 2017;54(4):595-604. doi:10.1177\/0300985817705175"},{"key":"ref9","series-title":"Ettinger\u2019s Textbook of Veterinary Internal Medicine","author":"Ettinger SJ","year":"2024","unstructured":"Ettinger SJ, Feldman EC, Cote E, eds. Ettinger\u2019s Textbook of Veterinary Internal Medicine. 9th ed. Elsevier; 2024."},{"issue":"1","key":"ref10","series-title":"J Small Anim Pract","first-page":"32","article-title":"How useful is abdominal ultrasonography in dogs with diarrhoea?","volume":"59","author":"Mapletoft EK","year":"2018","unstructured":"Mapletoft EK, Allenspach K, Lamb CR. How useful is abdominal ultrasonography in dogs with diarrhoea? J Small Anim Pract. 2018;59(1):32-37. doi:10.1111\/jsap.12780"},{"issue":"4","key":"ref11","series-title":"J Am Vet Med Assoc.","first-page":"487","article-title":"Retrospective evaluation of anemia and erythrocyte morphological anomalies in dogs with lymphoma or inflammatory bowel disease","volume":"254","author":"Parachini-Winter C","year":"2019","unstructured":"Parachini-Winter C, Carioto LM, Gara-Boivin C. Retrospective evaluation of anemia and erythrocyte morphological anomalies in dogs with lymphoma or inflammatory bowel disease. J Am Vet Med Assoc. 2019;254(4):487-495. doi:10.2460\/javma.254.4.487"},{"issue":"6","key":"ref12","series-title":"Animals (Basel).","first-page":"837","article-title":"Monocytes count, NLR, MLR and PLR in canine inflammatory bowel disease","volume":"14","author":"Marchesi MC","year":"2024","unstructured":"Marchesi MC, Maggi G, Cremonini V,  Monocytes count, NLR, MLR and PLR in canine inflammatory bowel disease. Animals (Basel). 2024;14(6):837. doi:10.3390\/ani14060837"},{"issue":"6","key":"ref13","series-title":"Animals (Basel).","first-page":"985","article-title":"Red blood cell distribution width as a novel parameter in canine disorders: literature review and future prospective","volume":"13","author":"Miglio A","year":"2023","unstructured":"Miglio A, Valente C, Guglielmini C. Red blood cell distribution width as a novel parameter in canine disorders: literature review and future prospective. Animals (Basel). 2023;13(6):985. doi:10.3390\/ani13060985"},{"issue":"1","key":"ref14","series-title":"Indian J Crit Care Med.","first-page":"49","article-title":"Red cell distribution width as a novel prognostic marker in multiple clinical studies","volume":"24","author":"Yousefi B","year":"2020","unstructured":"Yousefi B, Sanaie S, Ghamari AA, Soleimanpour H, Karimian A, Mahmoodpoor A. Red cell distribution width as a novel prognostic marker in multiple clinical studies. Indian J Crit Care Med. 2020;24(1):49-54. doi:10.5005\/jp-journals-10071-23328"},{"issue":"9","key":"ref15","series-title":"Oncotarget.","first-page":"16027","article-title":"Prognostic value of RDW in cancers: a systematic review and meta-analysis","volume":"8","author":"Hu L","year":"2017","unstructured":"Hu L, Li M, Ding Y,  Prognostic value of RDW in cancers: a systematic review and meta-analysis. Oncotarget. 2017;8(9):16027-16035. doi:10.18632\/oncotarget.13784"},{"issue":"9","key":"ref16","series-title":"Can Vet J.","first-page":"964","article-title":"Evaluation of red blood cell distribution width in dogs with various illnesses","volume":"60","author":"Martinez C","year":"2019","unstructured":"Martinez C, Mooney CT, Shiel RE, Tang PK, Mooney L, O\u2019Neill EJ. Evaluation of red blood cell distribution width in dogs with various illnesses. Can Vet J. 2019;60(9):964-971."},{"key":"ref17","series-title":"Front Vet Sci.","first-page":"1258857","article-title":"Comparison of visual assessments of anisocytosis in canine blood smears and analyzer-calculated red blood cell distribution width","volume":"10","author":"Jensen AL","year":"2023","unstructured":"Jensen AL, Krogh AKH, Nielsen LN. Comparison of visual assessments of anisocytosis in canine blood smears and analyzer-calculated red blood cell distribution width. Front Vet Sci. 2023;10:1258857. doi:10.3389\/fvets.2023.1258857"},{"issue":"4","key":"ref18","series-title":"Acta Vet Brno.","first-page":"385","article-title":"Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido","volume":"86","author":"Anio\u0142ek O","year":"2017","unstructured":"Anio\u0142ek O, Barc A, Jarosi\u0144ska A, Gajewski Z. Evaluation of frequency and intensity of asymptomatic anisocytosis in the Japanese dog breeds Shiba, Akita, and Hokkaido. Acta Vet Brno. 2017;86(4):385-391. doi:10.2754\/avb201786040385"},{"issue":"3","key":"ref19","series-title":"J Comp Pathol.","first-page":"269","article-title":"Investigations of bone marrow dyscrasia in a Poodle with macrocytosis","volume":"101","author":"Canfield PJ","year":"1989","unstructured":"Canfield PJ, Watson AD. Investigations of bone marrow dyscrasia in a Poodle with macrocytosis. J Comp Pathol. 1989;101(3):269-278. doi:10.1016\/0021-9975(89)90036-4"},{"issue":"3","key":"ref20","series-title":"Thromb Res.","first-page":"334","article-title":"Red cell distribution width and risk for venous thromboembolism: a population-based cohort study","volume":"133","author":"Z\u00f6ller B","year":"2014","unstructured":"Z\u00f6ller B, Melander O, Svensson P, Engstr\u00f6m G. Red cell distribution width and risk for venous thromboembolism: a population-based cohort study. Thromb Res. 2014;133(3):334-339. doi:10.1016\/j.thromres.2013.12.013"},{"issue":"2","key":"ref21","series-title":"Top Companion Anim Med.","first-page":"59","article-title":"Diseases associated with thrombosis","volume":"27","author":"de Laforcade A","year":"2012","unstructured":"de Laforcade A. Diseases associated with thrombosis. Top Companion Anim Med. 2012;27(2):59-64. doi:10.1053\/j.tcam.2012.07.002"},{"issue":"2","key":"ref22","series-title":"Vet Pathol.","first-page":"227","article-title":"Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples","volume":"59","author":"Kojima K","year":"2022","unstructured":"Kojima K, Chambers JK, Nakashima K, Goto-Koshino Y, Uchida K. Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples. Vet Pathol. 2022;59(2):227-235. doi:10.1177\/03009858211057220"},{"issue":"suppl 1","key":"ref23","series-title":"J Comp Pathol.","first-page":"S1","article-title":"World Small Animal Veterinary Association Gastrointestinal Standardization Group. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group","volume":"138","author":"Day MJ","year":"2008","unstructured":"Day MJ, Bilzer T, Mansell J, ; World Small Animal Veterinary Association Gastrointestinal Standardization Group. Histopathological standards for the diagnosis of gastrointestinal inflammation in endoscopic biopsy samples from the dog and cat: a report from the World Small Animal Veterinary Association Gastrointestinal Standardization Group. J Comp Pathol. 2008;138(suppl 1):S1-S43. doi:10.1016\/j.jcpa.2008.01.001"},{"key":"ref24","series-title":"Interpreting IDEXX ProCyte Dx Hematology Analyzer Dot Plots","author":"Idexx","year":"2023","unstructured":"Idexx. Interpreting IDEXX ProCyte Dx Hematology Analyzer Dot Plots. Idexx Laboratories Inc; 2023. Accessed March 11, 2026. https:\/\/www.idexx.com\/files\/dot-plot-procyte-dx-en.pdf"},{"issue":"8","key":"ref25","series-title":"J Small Anim Pract.","first-page":"603","article-title":"Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it","volume":"63","author":"Bergstrand E","year":"2022","unstructured":"Bergstrand E, Tvedten HW, Lillieh\u00f6\u00f6k I. Detection of frequent neutrophil misclassification by the ProCyte Dx in sick dogs and how to avoid it. J Small Anim Pract. 2022;63(8):603-608. doi:10.1111\/jsap.13499"},{"issue":"3","key":"ref26","series-title":"J Vet Intern Med.","first-page":"291","article-title":"A scoring index for disease activity in canine inflammatory bowel disease","volume":"17","author":"Jergens AE","year":"2003","unstructured":"Jergens AE, Schreiner CA, Frank DE,  A scoring index for disease activity in canine inflammatory bowel disease. J Vet Intern Med. 2003;17(3):291-297. doi:10.1111\/j.1939-1676.2003.tb02450.x"},{"issue":"4","key":"ref27","series-title":"J Vet Intern Med.","first-page":"700","article-title":"Chronic enteropathies in dogs: evaluation of risk factors for negative outcome","volume":"21","author":"Allenspach K","year":"2007","unstructured":"Allenspach K, Wieland B, Gr\u00f6ne A, Gaschen F. Chronic enteropathies in dogs: evaluation of risk factors for negative outcome. J Vet Intern Med. 2007;21(4):700-708. doi:10.1111\/j.1939-1676.2007.tb03011.x"},{"issue":"3","key":"ref28","series-title":"Bone Marrow Transplant.","first-page":"452","article-title":"Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics","volume":"48","author":"Kanda Y","year":"2013","unstructured":"Kanda Y. Investigation of the freely available easy-to-use software \u2018EZR\u2019 for medical statistics. Bone Marrow Transplant. 2013;48(3):452-458. doi:10.1038\/bmt.2012.244"},{"issue":"5","key":"ref29","series-title":"J Vet Intern Med","first-page":"732","article-title":"Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma?","volume":"19","author":"MacDonald VS","year":"2005","unstructured":"MacDonald VS, Thamm DH, Kurzman ID, Turek MM, Vail DM. Does L-asparaginase influence efficacy or toxicity when added to a standard CHOP protocol for dogs with lymphoma? J Vet Intern Med. 2005;19(5):732-736. doi:10.1111\/j.1939-1676.2005.tb02753.x"},{"issue":"3","key":"ref30","series-title":"Vet Clin Pathol.","first-page":"259","article-title":"Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma","volume":"34","author":"Marchetti V","year":"2005","unstructured":"Marchetti V, Benetti C, Citi S, Taccini V. Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol. 2005;34(3):259-263. doi:10.1111\/j.1939-165X.2005.tb00051.x"},{"issue":"7","key":"ref31","series-title":"Rev Med Vet (Toulouse).","first-page":"549","article-title":"Red blood cell distribution width (RDW) in the dog: a retrospective study of 1400 cases","volume":"152","author":"Perret D","year":"2001","unstructured":"Perret D, Trumel C, Diqu\u00e9lou A, Dossin O, Guelfi J, Espie C. Red blood cell distribution width (RDW) in the dog: a retrospective study of 1400 cases. Rev Med Vet (Toulouse). 2001;152(7):549-554."},{"issue":"3","key":"ref32","series-title":"Can Vet J.","first-page":"250","article-title":"Iron deficiency anemia","volume":"53","author":"Naigamwalla DZ","year":"2012","unstructured":"Naigamwalla DZ, Webb JA, Giger U. Iron deficiency anemia. Can Vet J. 2012;53(3):250-256."},{"issue":"8","key":"ref33","series-title":"Vet Sci.","first-page":"751","article-title":"Clinicopathological and endoscopic features of diffuse alimentary lymphoma in 18 dogs","volume":"12","author":"Bedel F","year":"2025","unstructured":"Bedel F, Betting A, Girod M,  Clinicopathological and endoscopic features of diffuse alimentary lymphoma in 18 dogs. Vet Sci. 2025;12(8):751. doi:10.3390\/vetsci12080751"},{"key":"ref34","series-title":"Small Animal Critical Care Medicine","first-page":"630","article-title":"Gastrointestinal hemorrhage","author":"Boysen SR","year":"2015","unstructured":"Boysen SR. Gastrointestinal hemorrhage. In: Small Animal Critical Care Medicine. Elsevier; 2015:630\u2013634. doi:10.1016\/B978-1-4557-0306-7.00119-7"},{"issue":"6","key":"ref35","series-title":"J Vet Intern Med.","first-page":"2618","article-title":"Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: a double-blind randomized trial","volume":"33","author":"Whittemore JC","year":"2019","unstructured":"Whittemore JC, Mooney AP, Price JM, Thomason J. Clinical, clinicopathologic, and gastrointestinal changes from administration of clopidogrel, prednisone, or combination in healthy dogs: a double-blind randomized trial. J Vet Intern Med. 2019;33(6):2618-2627. doi:10.1111\/jvim.15630"},{"issue":"9","key":"ref36","series-title":"Animals (Basel).","first-page":"2580","article-title":"Detection of anti-erythrocyte antibodies in dogs with inflammatory bowel disease (IBD)","volume":"11","author":"Gori E","year":"2021","unstructured":"Gori E, Pierini A, Nesci M,  Detection of anti-erythrocyte antibodies in dogs with inflammatory bowel disease (IBD). Animals (Basel). 2021;11(9):2580. doi:10.3390\/ani11092580"},{"issue":"11","key":"ref37","series-title":"Cureus.","first-page":"e74229","article-title":"The correlation of red cell distribution width with peripheral blood smear: a study from a tertiary care hospital in Peshawar","volume":"16","author":"Abbas S","year":"2024","unstructured":"Abbas S, Shah MM, Iftikhar M. The correlation of red cell distribution width with peripheral blood smear: a study from a tertiary care hospital in Peshawar. Cureus. 2024;16(11):e74229. doi:10.7759\/cureus.74229"},{"issue":"2","key":"ref38","series-title":"J Vet Res (Pulawy).","first-page":"325","article-title":"Analysis of red blood cell parameters in dogs with various stages of degenerative mitral valve disease","volume":"64","author":"Kumiega E","year":"2020","unstructured":"Kumiega E, Micha\u0142ek M, Kasztura M, Noszczyk-Nowak A. Analysis of red blood cell parameters in dogs with various stages of degenerative mitral valve disease. J Vet Res (Pulawy). 2020;64(2):325-332. doi:10.2478\/jvetres-2020-0043"},{"issue":"1","key":"ref39","series-title":"Vet Pathol.","first-page":"50","article-title":"Immunohistochemical profiling of canine intestinal T-Cell lymphomas","volume":"56","author":"Matsumoto I","year":"2019","unstructured":"Matsumoto I, Nakashima K, Goto-Koshino Y,  Immunohistochemical profiling of canine intestinal T-Cell lymphomas. Vet Pathol. 2019;56(1):50-60. doi:10.1177\/0300985818800015"},{"issue":"7","key":"ref40","series-title":"Leuk Lymphoma.","first-page":"1225","article-title":"The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study","volume":"64","author":"Castro D","year":"2023","unstructured":"Castro D, Valcarcel B, Runciman T,  The prognostic role of red cell distribution width on all-cause and cause-specific outcomes in peripheral T-cell lymphoma: a retrospective cohort study. Leuk Lymphoma. 2023;64(7):1225-1233. doi:10.1080\/10428194.2023.2205975"},{"issue":"4","key":"ref41","series-title":"Croat Med J.","first-page":"334","article-title":"Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study","volume":"56","author":"Peri\u0161a V","year":"2015","unstructured":"Peri\u0161a V, Zibar L, Sin\u010di\u0107-Petri\u010devi\u0107 J, Knezovi\u0107 A, Peri\u0161a I, Barbi\u0107 J. Red blood cell distribution width as a simple negative prognostic factor in patients with diffuse large B-cell lymphoma: a retrospective study. Croat Med J. 2015;56(4):334-343. doi:10.3325\/cmj.2015.56.334"},{"issue":"3","key":"ref42","series-title":"Animals (Basel).","first-page":"778","article-title":"Red cell distribution width has a negative prognostic role in dogs with myxomatous mitral valve disease","volume":"11","author":"Guglielmini C","year":"2021","unstructured":"Guglielmini C, Valentini CM, Contiero B, Valente C, Poser H. Red cell distribution width has a negative prognostic role in dogs with myxomatous mitral valve disease. Animals (Basel). 2021;11(3):778. doi:10.3390\/ani11030778"},{"issue":"24","key":"ref43","series-title":"Animals (Basel).","first-page":"3483","article-title":"Prognostic role of red cell distribution width and other routine clinico-pathological parameters in dogs with acute pancreatitis","volume":"12","author":"Guglielmini C","year":"2022","unstructured":"Guglielmini C, Crisi PE, Tardo AM,  Prognostic role of red cell distribution width and other routine clinico-pathological parameters in dogs with acute pancreatitis. Animals (Basel). 2022;12(24):3483. doi:10.3390\/ani12243483"},{"issue":"1","key":"ref44","series-title":"J Vet Emerg Crit Care (San Antonio).","first-page":"9","article-title":"Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs","volume":"32","author":"Ludwik TM","year":"2022","unstructured":"Ludwik TM, Heinrich DA, Rendahl A, Friedenberg SG. Red cell distribution width is a predictor of all-cause mortality in hospitalized dogs. J Vet Emerg Crit Care (San Antonio). 2022;32(1):9-17. doi:10.1111\/vec.13109"},{"issue":"4","key":"ref45","series-title":"Open Vet J.","first-page":"980","article-title":"Hematological ratios and indices in canine large B-cell lymphoma","volume":"14","author":"Gavazza A","year":"2024","unstructured":"Gavazza A, Cremonini V, Miglio A, Starita C, Rossi G, Antognoni MT. Hematological ratios and indices in canine large B-cell lymphoma. Open Vet J. 2024;14(4):980-989. doi:10.5455\/OVJ.2024.v14.i4.5"},{"key":"ref46","series-title":"Vet Immunol Immunopathol.","first-page":"106","article-title":"Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs","volume":"182","author":"Calvalido J","year":"2016","unstructured":"Calvalido J, Wood GA, Mutsaers AJ, Wood D, Sears W, Woods JP. Comparison of serum cytokine levels between dogs with multicentric lymphoma and healthy dogs. Vet Immunol Immunopathol. 2016;182:106-114. doi:10.1016\/j.vetimm.2016.10.009"},{"issue":"3","key":"ref47","series-title":"Vet Comp Oncol.","first-page":"337","article-title":"Clinical characteristics and outcome in dogs with small cell T-cell intestinal lymphoma","volume":"16","author":"Couto KM","year":"2018","unstructured":"Couto KM, Moore PF, Zwingenberger AL, Willcox JL, Skorupski KA. Clinical characteristics and outcome in dogs with small cell T-cell intestinal lymphoma. Vet Comp Oncol. 2018;16(3):337-343. doi:10.1111\/vco.12384"},{"issue":"2","key":"ref48","series-title":"J Vet Intern Med.","first-page":"317","article-title":"Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs","volume":"23","author":"Rassnick KM","year":"2009","unstructured":"Rassnick KM, Moore AS, Collister KE,  Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs. 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