{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T18:05:34Z","timestamp":1784570734527,"version":"3.55.0"},"reference-count":27,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe outcomes in cats with primary appendicular bone tumors treated with complete or partial amputation, with or without adjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed cats with histologically confirmed primary appendicular bone tumors treated surgically between 2008 and 2019. Data included signalment, clinical signs, tumor location, preoperative imaging, amputation level, adjunctive therapy, histologic characteristics, and oncologic outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>76 cats were included, with osteosarcoma being the most commonly diagnosed tumor. Median survival time (MST) for cats with osteosarcoma was 469 days, with 1- and 2-year survival rates of 56.8% and 40.4%, respectively. The MST for cats with chondrosarcoma was 1,302 days, with 1- and 2-year survival rates of 91.7% and 66.7%. Overall metastatic rate was 32.9%, and 36.2% for osteosarcoma specifically; scapular tumors had the highest metastatic rate (87.5%). Preoperative pulmonary metastasis significantly shortened MST in cats with osteosarcoma (152 vs 573 days). In cats with osteosarcoma without preoperative pulmonary metastasis, adjuvant chemotherapy significantly improved MST (1,466 vs 440 days). Negative prognostic indicators for cats with osteosarcoma were increased age and presence of suspected metastasis at any time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Appendicular osteosarcoma in cats had a good prognosis following amputation alone, despite a higher metastatic rate than previously reported; however, adjuvant chemotherapy significantly improved survival time in cats with nonmetastatic osteosarcoma. Appendicular chondrosarcoma had an excellent prognosis following definitive surgery alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance<\/jats:title>\n                    <jats:p>Cats with nonmetastatic osteosarcoma at diagnosis should be treated with both definitive surgery and adjuvant chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2460\/javma.25.11.0724","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:10:34Z","timestamp":1775841034000},"page":"1005-1013","source":"Crossref","is-referenced-by-count":0,"title":["Diagnosis and clinical outcome of cats with primary appendicular bone tumors: 76 cases"],"prefix":"10.2460","volume":"264","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9923-349X","authenticated-orcid":true,"given":"Shogo","family":"Kimura","sequence":"first","affiliation":[{"name":"Capital City Specialty and Emergency Animal Hospital, Kanata, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Lubelski","sequence":"additional","affiliation":[{"name":"Capital City Specialty and Emergency Animal Hospital, Kanata, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Wood","sequence":"additional","affiliation":[{"name":"VCA Canada Alta Vista Animal Hospital, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":true,"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl C.","family":"Maritato","sequence":"additional","affiliation":[{"name":"MedVet Cincinnati, Fairfax, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Morello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences, University of Turin, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-8909","authenticated-orcid":true,"given":"Mackenzie A.","family":"Pellin","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-4643","authenticated-orcid":true,"given":"Michelle L.","family":"Oblak","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6132-156X","authenticated-orcid":true,"given":"William T. N.","family":"Culp","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8809-8388","authenticated-orcid":true,"given":"Sarah","family":"Malek","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"Central Victoria Veterinary Hospital, Victoria, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Vernier","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia P.","family":"Sumner","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandan G.","family":"Wustefeld-Janssens","sequence":"additional","affiliation":[{"name":"Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel N.","family":"Schlag","sequence":"additional","affiliation":[{"name":"Burlington Emergency and Veterinary Specialists, Williston, VT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-7157","authenticated-orcid":true,"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[{"name":"Capital City Specialty and Emergency Animal Hospital, Kanata, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"issue":"2","key":"ref1","series-title":"J Natl Cancer Inst","first-page":"307","article-title":"Survey of animal neoplasms in Alameda and Contra Costa Counties, California, II: cancer morbidity in dogs and cats from Alameda County","volume":"40","author":"Dorn CR","year":"1968","unstructured":"Dorn CR, Taylor DO, Schneider R, Hibbard HH, Klauber MR. 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