{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:29:01Z","timestamp":1784064541607,"version":"3.55.0"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2017,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>CASE DESCRIPTION<\/jats:bold> 4 dogs were examined because of pleural effusion and ventricular tachycardia, coughing and supraventricular tachycardia, appendicular osteosarcoma, and syncopal episodes.<\/jats:p>\n<jats:p><jats:bold>CLINICAL FINDINGS<\/jats:bold> In all 4 dogs, a heart base tumor was identified by means of thoracic CT.<\/jats:p>\n<jats:p><jats:bold>TREATMENT AND OUTCOME<\/jats:bold> In all 4 dogs, the heart base tumors were treated by means of stereotactic body radiation therapy. Dogs were anesthetized, and neuromuscular blockade was achieved with atracurium or vecuronium. A circle rebreathing system with 15 m (50 feet) of anesthetic tubing coursing through the vault wall was used to connect the patient to the anesthesia machine, which was located in the control room. After a brief period of hyperventilation, an inspiratory breath was held at 20 cm H<jats:sub>2<\/jats:sub>O for the duration of beam delivery. Each beam delivery lasted between 30 and 100 seconds. Immediately following the breath hold, assisted ventilation was resumed. Mean treatment delivery time for each patient was 26 minutes; mean total anesthesia time was 89 minutes. All patients recovered without complications. There was no evidence of hemoglobin desaturation or hypercapnia during the anesthetic procedure.<\/jats:p>\n<jats:p><jats:bold>CLINICAL RELEVANCE<\/jats:bold> The technique allowed for control of the respiration cycle from outside the radiation vault and a short overall treatment time. No adverse effects were encountered. This procedure should be considered when delivering radiation to structures within the thoracic cavity.<\/jats:p>","DOI":"10.2460\/javma.250.2.199","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T13:24:50Z","timestamp":1483709090000},"page":"199-204","source":"Crossref","is-referenced-by-count":13,"title":["Neuromuscular blockade and inspiratory breath hold during stereotactic body radiation therapy for treatment of heart base tumors in four dogs"],"prefix":"10.2460","volume":"250","author":[{"given":"Krista L.","family":"Kelsey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsay N.","family":"Kubicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Bacon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheilah A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"209","article-title":"Normal tissue tolerance and management of radiation injury","volume":"10","author":"Gillette","year":"1995"},{"key":"ref2","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0195-5616(97)50004-0","article-title":"Radiation therapy toxicities","volume":"27","author":"Harris","year":"1997"},{"key":"ref3","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991"},{"key":"ref4","series-title":"Med Phys","doi-asserted-by":"publisher","first-page":"4078","DOI":"10.1118\/1.3438081","article-title":"Stereotactic body radiation therapy: the report of AAPM Task Group 101","volume":"37","author":"Benedict","year":"2010"},{"key":"ref5","series-title":"Med Phys","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1118\/1.2349696","article-title":"The management of respiratory motion in radiation oncology: report of AAPM Task Group 76","volume":"33","author":"Keall","year":"2006"},{"key":"ref6","series-title":"J Med Imaging Radiat Oncol","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1111\/1754-9485.12088","article-title":"Minimal benefit of respiratory-gated radiation therapy in the management of thoracic malignancy","volume":"57","author":"Hau","year":"2013"},{"key":"ref7","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.2460\/ajvr.70.11.1333","article-title":"Comparison of time to desaturation between preoxygenated and nonpreoxygenated dogs following sedation with acepromazine maleate and morphine and induction of anesthesia with propofol","volume":"70","author":"McNally","year":"2009"},{"key":"ref8","series-title":"Veterinary anaesthesia: principles to practice. Ames","first-page":"88","author":"Dugdale","year":"2010"},{"key":"ref9","series-title":"Emergency department resuscitation of the critically ill","first-page":"15","article-title":"The crashing ventilated patient","author":"Santanilla","year":"2011"},{"key":"ref10","series-title":"J Vet Med A Physiol Pathol Clin Med","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1439-0442.2007.00987.x","article-title":"Normal values and incidence of cardiorespiratory complications in dogs during general anaesthesia. A review of 1281 cases","volume":"54","author":"Redondo","year":"2007"},{"key":"ref11","series-title":"Acta Oncol","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3109\/0284186X.2014.932435","article-title":"Prospective phase II trial of image-guided radiotherapy in Hodgkin lymphoma: benefit of deep inspiration breath-hold","volume":"54","author":"Petersen","year":"2015"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/250\/2\/javma.250.2.199.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/250\/2\/javma.250.2.199.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/250\/2\/javma.250.2.199.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T11:51:56Z","timestamp":1741348316000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/250\/2\/javma.250.2.199.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,15]]},"references-count":11,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.2460\/javma.250.2.199","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1,15]]}}}