{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:07:03Z","timestamp":1770898023825,"version":"3.50.1"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2017,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the incidence of incompatible crossmatch results in dogs without a history of prior RBC transfusion and to evaluate changes in Hct following RBC administration for transfusion-na\u00efve dogs that did and did not have crossmatching performed.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Retrospective study.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 169 client-owned dogs.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Information obtained from the medical records included signalment, pretransfusion Hct or PCV, and crossmatching results where applicable. Dogs that underwent major crossmatching (n = 149) as part of pretransfusion screening were each crossmatched with 3 potential donors. Donor blood was obtained from a commercial source and tested negative for dog erythrocyte antigens (DEAs) 1.1, 1.2, and 7 but positive for DEA 4. Mean change in Hct after transfusion was compared between crossmatch-tested dogs (57\/91 that subsequently underwent RBC transfusion) and 20 other dogs that underwent RBC transfusion without prior crossmatching by statistical methods.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> 25 of 149 (17%) dogs evaluated by crossmatching were incompatible with 1 or 2 of the 3 potential donors. All 149 dogs were compatible with \u2265 1 potential donor. Mean \u00b1 SD change in Hct after transfusion was significantly higher in dogs that had crossmatching performed (12.5 \u00b1 8.6%) than in dogs that did not undergo crossmatching (9.0 \u00b1 4.3%).<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results indicated immunologic incompatibility can exist between first-time transfusion recipients and potential blood donor dogs. The clinical importance of these findings could not be evaluated, but considering the potential for immediate or delayed hemolytic transfusion reactions or shortened RBC life span, the authors suggest veterinarians consider crossmatching all dogs prior to transfusion when possible.<\/jats:p>","DOI":"10.2460\/javma.250.3.303","type":"journal-article","created":{"date-parts":[[2017,1,24]],"date-time":"2017-01-24T14:17:08Z","timestamp":1485267428000},"page":"303-308","source":"Crossref","is-referenced-by-count":29,"title":["Incidence of incompatible crossmatch results in dogs admitted to a veterinary teaching hospital with no history of prior red blood cell transfusion"],"prefix":"10.2460","volume":"250","author":[{"given":"Adesola","family":"Odunayo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayode","family":"Garraway","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barton 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