{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:21:45Z","timestamp":1793020905908,"version":"4.5.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2017,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine survival times of selected dogs with metastatic (stage III) osteosarcoma, whether disease-free interval (DFI) was associated with survival time after diagnosis of stage III disease (ie, stage III survival time), and whether a survival benefit of metastasectomy existed.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Retrospective case series with nested cohort study.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 194 client-owned dogs treated for histologically confirmed appendicular osteosarcoma from 1997 through 2009.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs were included if they had stage I or II osteosarcoma at the time of initial evaluation, had amputation of the affected appendage and \u2265 1 dose of chemotherapy afterward, and developed metastasis within the follow-up period or prior to death. Data collected from the medical records included signalment, primary tumor location, clinical and laboratory findings, whether metastasectomy was performed, and outcome. Various factors were examined for associations with outcome.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Dogs that received no treatment for the metastasis had a median survival time between 49 and 57 days after diagnosis of stage III osteosarcoma. Duration of the preceding DFI had no association with this period. Metastasectomy alone was associated with a longer median stage III survival time (232 days) than no metastasectomy (49 days). Among all dogs identified as qualifying for pulmonary metastasectomy on the basis of &lt; 3 pulmonary nodules visible on thoracic radiographs and a DFI &gt; 275 days (n = 21), a survival advantage was also identified for those that actually received pulmonary metastasectomy (6).<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Preceding DFI had no influence on survival time of dogs with stage III osteosarcoma. Metastasectomy was associated with an increase in survival time for selected dogs.<\/jats:p>","DOI":"10.2460\/javma.251.11.1293","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T15:57:43Z","timestamp":1511193463000},"page":"1293-1305","source":"Crossref","is-referenced-by-count":28,"title":["Prognosis for dogs with stage III osteosarcoma following treatment with amputation and chemotherapy with and without metastasectomy"],"prefix":"10.2460","volume":"251","author":[{"given":"Hailey","family":"Turner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"S\u00e9guin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna R.","family":"Worley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole 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