{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:12:19Z","timestamp":1789143139021,"version":"build-2803163510"},"reference-count":44,"publisher":"American Veterinary Medical Association (AVMA)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To evaluate the effects of IV diphenhydramine hydrochloride administration on cardiorespiratory variables in anesthetized dogs undergoing mast cell tumor (MCT) excision.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Randomized, blinded clinical trial.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 16 client-owned dogs with MCTs.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> In a standardized isoflurane anesthesia session that included mechanical ventilation, dogs received diphenhydramine hydrochloride (1 mg\/kg [0.45 mg\/lb], IV; n = 8) or an equivalent volume of saline (0.9% NaCl) solution (IV; control treatment; 8) 10 minutes after induction. Cardiorespiratory variables were recorded throughout anesthesia and MCT excision, and blood samples for determination of plasma diphenhydramine and histamine concentrations were collected prior to premedication (baseline), throughout anesthesia, and 2 hours after extubation.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Cardiorespiratory values in both treatment groups were acceptable for anesthetized dogs. Mean \u00b1 SD diastolic arterial blood pressure was significantly lower in the diphenhydramine versus control group during tumor dissection (52 \u00b1 10 mm Hg vs 62 \u00b1 9 mm Hg) and surgical closure (51 \u00b1 10 mm Hg vs 65 \u00b1 9 mm Hg). Mean arterial blood pressure was significantly lower in the diphenhydramine versus control group during surgical closure (65 \u00b1 12 mm Hg vs 78 \u00b1 11 mm Hg), despite a higher cardiac index value. Plasma histamine concentrations were nonsignificantly higher than baseline during maximal manipulation of the tumor and surgical preparation in the diphenhydramine group and during surgical dissection in the control group.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> IV administration of diphenhydramine prior to MCT excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs.<\/jats:p>","DOI":"10.2460\/javma.251.7.804","type":"journal-article","created":{"date-parts":[[2017,10,2]],"date-time":"2017-10-02T14:00:38Z","timestamp":1506952838000},"page":"804-813","source":"Crossref","is-referenced-by-count":10,"title":["Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors"],"prefix":"10.2460","volume":"251","author":[{"given":"Andrea","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Valverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Mosley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony 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