{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:29:35Z","timestamp":1784831375279,"version":"3.55.0"},"reference-count":47,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2017,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the incidence of and risk factors for clinical feline herpesvirus (FHV) infection in zoo-housed cheetahs and determine whether dam infection was associated with offspring infection.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Retrospective cohort study.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 144 cheetah cubs born in 6 zoos from 1988 through 2007.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Data were extracted from the health records of cheetahs and their dams to identify incident cases of clinical FHV infection and estimate incidence from birth to 18 months of age. Univariate and multivariable Cox proportional hazards models, controlling for correlations among cheetahs with the same dam, were used to identify risk factors for incident FHV infection.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Cumulative incidence of FHV infection in cheetah cubs was 35% (50\/144). No significant association between dam and offspring infection was identified in any model. Factors identified as significant through multivariable analysis varied by age group. For cheetahs up to 3 months of age, the most important predictor of FHV infection was having a dam that had received a preparturition FHV vaccine regimen that included a modified-live virus vaccine versus a dam that had received no preparturition vaccine. Other risk factors included being from a small litter, being born to a primiparous dam, and male sex.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> This study provided the first population-level characterization of the incidence of and risk factors for FHV infection in cheetahs, and findings confirmed the importance of this disease. Recognition that clinical FHV infection in the dam was not a significant predictor of disease in cubs and identification of other significant factors have implications for disease management.<\/jats:p>","DOI":"10.2460\/javma.251.8.946","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T12:26:05Z","timestamp":1506687965000},"page":"946-956","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology of clinical feline herpesvirus infection in zoo-housed cheetahs (Acinonyx jubatus)"],"prefix":"10.2460","volume":"251","author":[{"given":"Carmel L.","family":"Witte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Lamberski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce 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associated with persistent feline herpes virus infection in cheetahs (Acinonyx jubatus)","volume":"41","author":"Munson","year":"2004"},{"key":"ref5","series-title":"J Zoo Wildl Med","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1638\/2014-0206.1","article-title":"Treatment of chronic herpesviral dermatitis in a captive cheetah (Acinonyx jubatus) in Namibia","volume":"46","author":"Flacke","year":"2015"},{"key":"ref6","series-title":"Zoo Biol","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/zoo.1430120111","article-title":"Infectious disease surveillance in captive and free-living cheetahs: an integral part of the species survival plan","volume":"12","author":"Evermann","year":"1993"},{"key":"ref7","series-title":"J Wildl Dis","doi-asserted-by":"publisher","first-page":"23","DOI":"10.7589\/0090-3558-40.1.23","article-title":"Serosurvey of viral infections in free-ranging Namibian cheetahs (Acinonyx jubatus)","volume":"40","author":"Munson","year":"2004"},{"key":"ref8","series-title":"Clin Vaccine Immunol","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1128\/CVI.00345-09","article-title":"Seroprevalences to viral pathogens in free-ranging and captive cheetahs (Acinonyx jubatus) on Namibian farmland","volume":"17","author":"Thalwitzer","year":"2010"},{"key":"ref9","series-title":"J Wildl Dis","doi-asserted-by":"publisher","first-page":"542","DOI":"10.7589\/0090-3558-41.3.542","article-title":"Extrinsic factors significantly affect patterns of disease in free-ranging and captive cheetah (Acinonyx jubatus) populations","volume":"41","author":"Munson","year":"2005"},{"key":"ref10","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1136\/vr.111.16.359","article-title":"Transmission of feline viral rhinotracheitis","volume":"111","author":"Gaskell","year":"1982"},{"key":"ref11","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jfms.2003.08.008","article-title":"Common virus infections in cats, before and after being placed in shelters, with emphasis on feline enteric coronavirus","volume":"6","author":"Pedersen","year":"2004"},{"key":"ref12","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/vr.156.21.669","article-title":"Factors associated with upper respiratory tract disease caused by feline herpesvirus, feline calicivirus, Chlamydophila felis and Bordetella bronchiseptica in cats: experience from 218 European catteries","volume":"156","author":"Helps","year":"2005"},{"key":"ref13","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jfms.2004.07.004","article-title":"Epidemiologic evaluation of multiple respiratory pathogens in cats in animal shelters","volume":"7","author":"Bannasch","year":"2005"},{"key":"ref14","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1053\/jfms.2000.0084","article-title":"A study of feline upper respiratory tract disease with reference to prevalence and risk factors for infection with feline calicivirus and feline herpesvirus","volume":"2","author":"Binns","year":"2000"},{"key":"ref15","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.jfms.2009.05.003","article-title":"Feline herpesvirus infection: ABCD guidelines on prevention and management","volume":"11","author":"Thiry","year":"2009"},{"key":"ref16","series-title":"Vet Res","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1051\/vetres:2006063","article-title":"Feline herpesvirus","volume":"38","author":"Gaskell","year":"2007"},{"key":"ref17","series-title":"Vet J","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.tvjl.2008.05.025","article-title":"Onset of immunity in kittens after vaccination with a non-adjuvanted vaccine against feline panleucopenia, feline calicivirus and feline herpesvirus","volume":"182","author":"Jas","year":"2009"},{"key":"ref18","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jfms.2005.12.001","article-title":"Effects of a single dose of an intranasal feline herpesvirus 1, calicivirus, and panleukopenia vaccine on clinical signs and virus shedding after challenge with virulent feline herpesvirus 1","volume":"8","author":"Lappin","year":"2006"},{"key":"ref19","series-title":"Virology","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1006\/viro.1996.8393","article-title":"Vaccination of cats for feline rhinotracheitis results in a quantitative reduction of virulent feline herpesvirus-1 latency load after challenge","volume":"228","author":"Sussman","year":"1997"},{"key":"ref20","series-title":"J Zoo Wildl Med","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1638\/2012-0183R.1","article-title":"Development of a case definition for clinical feline herpesvirus infection in cheetahs (Acinonyx jubatus) housed in zoos","volume":"44","author":"Witte","year":"2013"},{"key":"ref21","series-title":"Applied survival analysis","author":"Hosmer","year":"2008"},{"key":"ref22","series-title":"J Am Stat Assoc","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1080\/01621459.1989.10478874","article-title":"The robust inference for the Cox proportional hazards model","volume":"84","author":"Lin","year":"1989"},{"key":"ref23","series-title":"Analysis of survival data with clustered events","author":"Gharibvand","year":"2009"},{"key":"ref24","series-title":"Biometrika","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1093\/biomet\/81.3.607","article-title":"Efficient computation of subset selection probabilities with application to Cox regression","volume":"81","author":"DeLong","year":"1994"},{"key":"ref25","series-title":"J Comp Pathol","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/0021-9975(79)90057-4","article-title":"The dose response of cats to experimental infection with feline viral rhinotracheitis virus","volume":"89","author":"Gaskell","year":"1979"},{"key":"ref26","series-title":"Veterinary epidemiologic research","first-page":"257","author":"Dohoo","year":"2009"},{"key":"ref27","series-title":"Infectious diseases","first-page":"12","year":"2005"},{"key":"ref28","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.2460\/javma.229.9.1405","article-title":"The 2006 American Association of Feline Practitioners Feline Vaccine Advisory Panel report","volume":"229","author":"Richards","year":"2006"},{"key":"ref29","series-title":"J Wildl Dis","doi-asserted-by":"publisher","first-page":"578","DOI":"10.7589\/0090-3558-27.4.578","article-title":"Antibody response of captive cheetahs to modified-live feline virus vaccine","volume":"27","author":"Spencer","year":"1991"},{"key":"ref30","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.cvsm.2010.02.002","article-title":"Adverse vaccine events in dogs and cats","volume":"40","author":"Moore","year":"2010"},{"key":"ref31","series-title":"J Am Vet Med Assoc","first-page":"1851","article-title":"Risks associated with the use of live vaccines","volume":"196","author":"Tizard","year":"1990"},{"key":"ref32","series-title":"J Zoo Wildl Med","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1638\/2013-0216R1.1","article-title":"Herpesvirus and calicivirus infection in a black-footed cat (Felis nigripes) family group following vaccination","volume":"46","author":"Rivas","year":"2015"},{"key":"ref33","series-title":"J Zoo Wildl Med","first-page":"109","article-title":"The response of cheetahs (Acinonyx jubatus) to routine vaccination","volume":"24","author":"Wack","year":"1993"},{"key":"ref34","series-title":"Reprod Domest Anim","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1111\/j.1439-0531.2008.01144.x","article-title":"Captive breeding of cheetahs in South Africa\u201330 years of data from the de Wildt Cheetah and Wildlife Centre","volume":"43","author":"Bertschinger","year":"2008"},{"key":"ref35","series-title":"Zoo Biol","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/(SICI)1098-2361(1999)18:2<129::AID-ZOO4>3.0.CO;2-9","article-title":"Analyses of factors influencing the birth weight and neonatal growth rate of cheetah (Acinonyx jubatus) cubs","volume":"18","author":"Beekman","year":"1999"},{"key":"ref36","series-title":"J Anim Sci","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.2527\/jas.2011-4874","article-title":"Effect of dam parity on litter performance, transfer of passive immunity, and progeny microbial ecology","volume":"91","author":"Carney-Hinkle","year":"2013"},{"key":"ref37","series-title":"Animal","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1017\/S1751731113001444","article-title":"Factors associated with the concentration of immunoglobulin G in the colostrum of dairy cows","volume":"7","author":"Conneely","year":"2013"},{"key":"ref38","series-title":"Front Immunol","first-page":"446","article-title":"Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies","volume":"5","author":"Niewiesk","year":"2014"},{"key":"ref39","series-title":"J Feline Med Surg","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1177\/1098612X11432239","article-title":"Effects of maternally-derived antibodies on serologic responses to vaccination in kittens","volume":"14","author":"DiGangi","year":"2012"},{"key":"ref40","series-title":"Am J Pathol","first-page":"173","article-title":"Experimental feline herpesvirus infection in the pregnant cat","volume":"65","author":"Hoover","year":"1971"},{"key":"ref41","series-title":"Am J Vet Res","first-page":"1455","article-title":"Morbidity and mortality in neonatal kittens","volume":"45","author":"Lawler","year":"1984"},{"key":"ref42","series-title":"Anim Reprod Sci","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.anireprosci.2013.11.006","article-title":"Factors influencing breeding success, ovarian cyclicity, and cub survival in zoo-managed tigers (Panthera tigris)","volume":"144","author":"Saunders","year":"2014"},{"key":"ref43","series-title":"Parasitology","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1017\/S0031182012001862","article-title":"Differential association between circulating testosterone and infection risk by several viruses in natural cat populations: a behavioural-mediated effect?","volume":"140","author":"Hellard","year":"2013"},{"key":"ref44","series-title":"Biol Sex Differ","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2042-6410-4-16","article-title":"Sex and inflammation in respiratory diseases: a clinical viewpoint","volume":"4","author":"Casimir","year":"2013"},{"key":"ref45","series-title":"Annu Rev Public Health","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev.publhealth.18.1.83","article-title":"Censoring issues in survival analysis","volume":"18","author":"Leung","year":"1997"},{"key":"ref46","series-title":"J Wildl Dis","doi-asserted-by":"publisher","first-page":"259","DOI":"10.7589\/0090-3558-40.2.259","article-title":"Evidence for chronic stress in captive but not free-ranging cheetahs (Acinonyx jubatus) based on adrenal morphology and function","volume":"40","author":"Terio","year":"2004"},{"key":"ref47","series-title":"J Wildl Dis","doi-asserted-by":"publisher","first-page":"102","DOI":"10.7589\/0090-3558-28.1.102","article-title":"Decline in maternal immunity and antibody response to vaccine 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