{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:56:47Z","timestamp":1792180607183,"version":"4.4.0"},"reference-count":52,"publisher":"American Veterinary Medical Association (AVMA)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2018,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To determine the effects of an omega-3 fatty acid and protein\u2013enriched diet, physical rehabilitation, or both on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy and arthroscopic surgery for treatment of cranial cruciate ligament disease.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Randomized, prospective clinical trial.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 48 dogs with unilateral cranial cruciate ligament disease.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs were randomly assigned to receive a dry omega-3 fatty acid and protein\u2013enriched dog food formulated to support joint health (test food [TF]), a dry food formulated for adult canine maintenance (control food [CF]), TF plus rehabilitation, or CF plus rehabilitation after surgery. Synovial fluid prostaglandin (PG) E<jats:sub>2<\/jats:sub> and interleukin-1\u03b2 concentrations, radiographic osteoarthritis scores, osteotomy site healing, and patellar ligament thickness were assessed at predetermined time points up to 6 months after surgery.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Dogs that received CF had significantly higher PGE<jats:sub>2<\/jats:sub> concentrations over time following surgery than did dogs that received TF, regardless of rehabilitation status. Synovial fluid interleukin-1\u03b2 concentrations did not change over time in any groups. Diet and rehabilitation were both associated with osteoarthritis scores, with significantly lower scores over time for dogs that received TF versus CF and for dogs that underwent rehabilitation versus those that did not. Proportions of dogs with complete osteotomy healing 8 and 24 weeks after surgery were significantly lower for dogs that received TF than for dogs that received CF, regardless of rehabilitation status.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Results suggested that feeding the TF can result in lower synovial fluid PGE<jats:sub>2<\/jats:sub> concentrations and that both the TF and rehabilitation can reduce progression of osteoarthritis in the 6 months following tibial plateau leveling osteotomy; clinical relevance of slower osteotomy healing in dogs fed the TF was unclear.<\/jats:p>","DOI":"10.2460\/javma.252.6.701","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T15:52:04Z","timestamp":1520265124000},"page":"701-709","source":"Crossref","is-referenced-by-count":14,"title":["Assessment of the effects of diet and physical rehabilitation on radiographic findings and markers of synovial inflammation in dogs following 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