{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:56:38Z","timestamp":1789736198463,"version":"4.0.1"},"reference-count":20,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"Abstract<\/jats:title>\n \n OBJECTIVE<\/jats:bold>\n To determine survival time and metastatic rate for dogs with early-stage anal sac adenocarcinoma (ASACA) treated with surgery alone and assess whether specific clinical, pathological, or immunohistochemical factors were predictive of outcome for those dogs.\n <\/jats:p>\n \n DESIGN<\/jats:bold>\n Retrospective case series.\n <\/jats:p>\n \n ANIMALS<\/jats:bold>\n 34 dogs with early-stage, nonmetastatic ASACA that were treated with surgery only.\n <\/jats:p>\n \n PROCEDURES<\/jats:bold>\n Medical record databases of 2 referral hospitals were searched to identify dogs examined between 2002 and 2013 that had a diagnosis of nonmetastatic ASACA that was < 3.2 cm at its largest diameter. Only dogs that received surgical treatment alone were included in the study. For each dog, information extracted from the medical record included signalment, clinical and diagnostic test findings, tumor characteristics, and outcome. When available, archived tumor specimens were histologically reviewed and tumor characteristics were described; Ki-67 and E-cadherin expressions were evaluated by use of immunohistochemical methods. Clinical, pathological, and immunohistochemical factors were assessed for associations with survival time and tumor recurrence and metastasis rates.\n <\/jats:p>\n \n RESULTS<\/jats:bold>\n Median survival time was 1,237 days. Seven dogs had tumor recurrence and 9 dogs developed metastatic disease at a median of 354 and 589 days, respectively, after primary tumor removal. Cellular pleomorphism was positively associated with development of metastatic disease. No other factors evaluated were associated with outcome.\n <\/jats:p>\n \n CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold>\n Results indicated dogs with early-stage nonmetastatic ASACA generally had a favorable outcome following surgical removal of the primary tumor alone. Routine rectal examination may be a simple and useful method for detection of dogs with early-stage ASACA.\n <\/jats:p>","DOI":"10.2460\/javma.253.1.84","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T09:35:31Z","timestamp":1529314531000},"page":"84-91","source":"Crossref","is-referenced-by-count":35,"title":["Outcome and clinical, pathological, and immunohistochemical factors associated with prognosis for dogs with early-stage anal sac adenocarcinoma treated with surgery alone: 34 cases (2002\u20132013)"],"prefix":"10.2460","volume":"253","author":[{"given":"Katherine A.","family":"Skorupski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Philippe","family":"de Lorimier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise E. B.","family":"LaDouceur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos O.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Rebhun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Tijdschr Diergeneeskd","first-page":"1069","article-title":"Pseudohyperparathyroidism associated with perirectal adenocarcinomas in elderly female dogs","volume":"103","author":"Rijnberk","year":"1978"},{"key":"ref2","series-title":"Vet Pathol","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1177\/030098588101800405","article-title":"Hypercalcemia associated with an adenocarcinoma derived from the apocrine glands of the anal sac","volume":"18","author":"Meuten","year":"1981"},{"key":"ref3","series-title":"J Am Anim Hosp 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