{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T16:23:21Z","timestamp":1793809401279,"version":"4.6.1"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>CASE DESCRIPTION<\/jats:title>\n<jats:p>A 4.5-year-old neutered male domestic ferret (<jats:italic>Mustela putorius furo<\/jats:italic>) was examined because of clinical signs compatible with neuromuscular disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>CLINICAL FINDINGS<\/jats:title>\n<jats:p>Results of electrophysiologic assessment, including measurement of compound muscle action potentials following repetitive nerve stimulation, and measurement of the anti\u2013acetylcholine receptor antibody titer were consistent with a diagnosis of acquired myasthenia gravis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>TREATMENT AND OUTCOME<\/jats:title>\n<jats:p>Medical treatment with pyridostigmine and prednisolone was instituted. The first signs of clinical improvement were observed 2 months later, followed by a slow but steady improvement over the next months. Anti\u2013acetylcholine receptor antibody titer was measured 10 months after initiation of treatment and was markedly decreased, compared with the initial titer. Pyridostigmine and prednisolone dosages were tapered over the following 4 months without any evidence of recurrence of clinical signs. Thirty months after initial examination, the ferret was clinically normal and not receiving any treatment. A follow-up anti\u2013acetylcholine receptor antibody titer was similar to previously published values for healthy ferrets.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Findings indicated that clinical and serologic remission can be achieved in ferrets with myasthenia gravis. However, owner willingness to provide extensive supportive care was vital to the outcome for this patient, as was the owner's decision to not euthanize the ferret despite an initial lack of response to treatment.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.254.10.1192","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T18:28:48Z","timestamp":1556648928000},"page":"1192-1195","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and serologic remission of acquired myasthenia gravis in a domestic ferret (Mustela putorius furo)"],"prefix":"10.2460","volume":"254","author":[{"given":"Stella","family":"Papageorgiou","sequence":"first","affiliation":[{"name":"1Clinique V\u00e9t\u00e9rinaire ADVETIA, 5 Rue Dubrunfaut, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Gnirs","sequence":"additional","affiliation":[{"name":"1Clinique V\u00e9t\u00e9rinaire ADVETIA, 5 Rue Dubrunfaut, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Quinton","sequence":"additional","affiliation":[{"name":"1Clinique V\u00e9t\u00e9rinaire ADVETIA, 5 Rue Dubrunfaut, 75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Diane","family":"Shelton","sequence":"additional","affiliation":[{"name":"2Comparative Neuromuscular Laboratory and Department of Pathology, School of Medicine, University of California\u2013San Diego, La Jolla, CA 92093."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Vet Med Int","first-page":"756321","article-title":"Electrodiagnostic examination of the tibial nerve in clinically normal ferrets","volume":"2010","author":"Bianchi","year":"2010"},{"key":"ref2","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.2460\/javma.235.12.1462","article-title":"Autoimmune myasthenia gravis in a ferret","volume":"235","author":"Couturier","year":"2009"},{"key":"ref3","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0195-5616(03)00085-8","article-title":"Myasthenia gravis and disorders of neuromuscular transmission","volume":"32","author":"Shelton","year":"2002"},{"key":"ref4","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/S0195-5616(94)50079-2","article-title":"Immune-mediated muscle disease","volume":"24","author":"Lewis","year":"1994"},{"key":"ref5","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1111\/jvim.13596","article-title":"Risk factors and outcomes in cats with acquired myasthenia gravis (2001\u20132012)","volume":"29","author":"Hague","year":"2015"},{"key":"ref6","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1111\/j.1939-1676.1997.tb00073.x","article-title":"Clinical forms of acquired myasthenia gravis in dogs: 25 cases (1988\u20131995)","volume":"11","author":"Dewey","year":"1997"},{"key":"ref7","series-title":"Veterinary clinical immunology: from classroom to clinics","first-page":"104","article-title":"Neuromuscular disorders","author":"Lewis","year":"1989"},{"key":"ref8","series-title":"Semin Vet Med Surg (Small Anim)","first-page":"126","article-title":"Disorders of neuromuscular transmission","volume":"4","author":"Shelton","year":"1989"},{"key":"ref9","series-title":"Prog Vet Neurol","first-page":"129","article-title":"Disorders of the neuromuscular junction","volume":"2","author":"Wheeler","year":"1991"},{"key":"ref10","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0195-5616(00)50003-5","article-title":"Selected disorders of muscle and the neuromuscular junction","volume":"30","author":"Taylor","year":"2000"},{"key":"ref11","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1748-5827.2012.01273.x","article-title":"Immune-mediated myasthenia gravis in a methimazole-treated cat","volume":"53","author":"Bell","year":"2012"},{"key":"ref12","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1212\/WNL.57.11.2139","article-title":"Spontaneous remission in canine myasthenia gravis: implications for assessing human MG therapies","volume":"57","author":"Shelton","year":"2001"},{"key":"ref13","series-title":"Prog Vet Neurol","first-page":"117","article-title":"Neuromuscular dysfunction in five dogs with acquired myasthenia gravis and presumptive hypothyroidism","volume":"6","author":"Dewey","year":"1995"},{"key":"ref14","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/j.1748-5827.1998.tb03734.x","article-title":"Myasthenia gravis: lessons from the past 10 years","volume":"39","author":"Shelton","year":"1998"},{"key":"ref15","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/S1474-4422(15)00145-3","article-title":"Myasthenia gravis: subgroup classification and therapeutic strategies","volume":"14","author":"Gilhus","year":"2015"},{"key":"ref16","series-title":"J Am Vet Med Assoc","first-page":"1355","article-title":"Clinical and pathologic features of thymoma in 15 dogs","volume":"184","author":"Aronsohn","year":"1984"},{"key":"ref17","series-title":"J Am Anim Hosp Assoc","first-page":"63","article-title":"Thymoma and acquired myasthenia gravis in the dog: a case report and review of 13 additional cases","volume":"28","author":"Klebanow","year":"1992"},{"key":"ref18","series-title":"Prog Vet Neurol","first-page":"311","article-title":"Use of repetitive nerve stimulation to assess neuromuscular function in dogs. 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