{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:56:35Z","timestamp":1792101395236,"version":"4.4.0"},"reference-count":21,"publisher":"American Veterinary Medical Association (AVMA)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:p><jats:bold>OBJECTIVE<\/jats:bold> To compare improvements in values for periodontal disease indices in dogs following treatment with closed root planing (CRP) alone, CRP with concurrent 8.5% doxycycline hyclate gel application, and CRP with concurrent 2% clindamycin hydrochloride reverse-polymer hydrogel application.<\/jats:p>\n<jats:p><jats:bold>DESIGN<\/jats:bold> Randomized, blinded, controlled clinical trial.<\/jats:p>\n<jats:p><jats:bold>ANIMALS<\/jats:bold> 34 client-owned dogs with periodontal pockets measuring 3.5 to 5.5 mm deep.<\/jats:p>\n<jats:p><jats:bold>PROCEDURES<\/jats:bold> Dogs were randomly assigned to receive 1 of 3 treatments: CRP alone (n = 10) or CRP plus 8.5% doxycycline hyclate (12) or 2% clindamycin hydrochloride (12) gel applied within the periodontal pockets. Indices of periodontal disease severity were recorded before and 12 weeks after treatment, and outcomes were compared among treatment groups.<\/jats:p>\n<jats:p><jats:bold>RESULTS<\/jats:bold> Except for gingivitis index, no significant differences were identified among the 3 treatment groups in the amount of improvement observed in values for periodontal disease indices following treatment. A minor but clinically unimportant improvement in mean gingivitis index values was identified for dogs treated with CRP plus doxycycline gel, which differed significantly from improvements in the other 2 groups. Teeth that were initially more severely affected (pocket depths, 5.0 to 5.5 mm) had the greatest amount of improvement, whereas teeth with only mildly high initial pocket depths (3.5 to 4.0 mm) had less improvement.<\/jats:p>\n<jats:p><jats:bold>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:bold> Overall, addition of doxycycline or clindamycin gel application to CRP for the treatment of periodontal disease in dogs yielded no clinically relevant benefit over CRP during the 12-week follow-up period.<\/jats:p>","DOI":"10.2460\/javma.254.3.373","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T20:41:55Z","timestamp":1548189715000},"page":"373-379","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of closed root planing with versus without concurrent doxycycline hyclate or clindamycin hydrochloride gel application for the treatment of periodontal disease in dogs"],"prefix":"10.2460","volume":"254","author":[{"given":"Django P.","family":"Martel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Carmichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Am Vet Med Assoc","first-page":"1336","article-title":"Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States","volume":"214","author":"Lund","year":"1999"},{"key":"ref2","series-title":"Veterinary dentistry principles and practice","first-page":"351","article-title":"Oral exam and diagnosis","author":"Wiggs","year":"1997"},{"key":"ref3","series-title":"J Vet 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Periodontol","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1902\/jop.1996.67.11.1176","article-title":"Periodontal pocket treatment in Beagle dogs using subgingival doxycycline from a biodegradable system","volume":"67","author":"Polson","year":"1996"},{"key":"ref13","series-title":"Vet Ther","first-page":"441","article-title":"Treatment of periodontal pockets with doxycycline in Beagles","volume":"3","author":"Zetner","year":"2002"},{"key":"ref14","series-title":"J Vet Dent","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1177\/089875641102800402","article-title":"Canine periodontal disease control using a clindamycin hydrochloride gel","volume":"28","author":"Johnston","year":"2011"},{"key":"ref15","series-title":"J Clin Periodontol","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/jcpe.12026","article-title":"A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis","volume":"40","author":"Matesanz-P\u00e9rez","year":"2013"},{"key":"ref16","series-title":"Evid Based Dent","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/sj.ebd.6400955","article-title":"Local antimicrobials in addition to scaling and root planing provide statistically significant but not clinically important benefit","volume":"14","author":"Matthews","year":"2013"},{"key":"ref17","series-title":"Int J Nanomedicine","first-page":"285","article-title":"Controlled-release of tetracycline and lovastatin by poly(d,l-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs","volume":"11","author":"Lee","year":"2016"},{"key":"ref18","series-title":"Stages of periodontal disease","year":"2016"},{"key":"ref19","series-title":"J Periodontol","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1902\/jop.2000.71.3.497","article-title":"Radiographic and digital imaging in 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