{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:46:23Z","timestamp":1784133983024,"version":"3.55.0"},"reference-count":17,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo evaluate the utility of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained by diffusion-weighted MRI (DWI) at 3.0 T for differentiating intracranial neoplastic lesions from noninfectious inflammatory lesions (NIILs) in dogs.<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n54 dogs that met inclusion criteria (ie, had a histologically confirmed intracranial lesion and DWI of the brain performed) with 5 lesion types: meningioma [n = 18], glioma [14], metastatic hemangiosarcoma [3], other metastatic neoplasms [5], and NIIL [14]).<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nTwo observers, who were blinded to the histologic diagnoses, independently determined the mean ADC and FA values for each evaluated intracranial lesion on the basis of 3 circular regions of interest on DWI images. Findings were compared among the 5 lesion types, between all neoplasms combined and NIILs, and between the 5 legion types and previously determined values for corresponding locations for neurologically normal dogs.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nThe mean ADC and FA values did not differ significantly among the 5 lesion types or between all neoplasms combined and NIILs. However, 35% (14\/40) of the neoplastic lesions had an ADC value \u2265 1.443 \u00d7 10\u22123<\/jats:sup> mm2<\/jats:sup>\/s, whereas all NIILs had ADC values < 1.443 \u00d7 10\u22123<\/jats:sup> mm2<\/jats:sup>\/s. Meningiomas and NIILs had FA values that were significantly lower than those for neurologically normal dogs.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nIn this population of dogs, the FA values for meningiomas and NIILs differed significantly from those previously reported for neurologically normal dogs. In addition, an ADC cutoff value of 1.443 \u00d7 10\u22123<\/jats:sup> mm2<\/jats:sup>\/s appeared to be highly specific for diagnosing neoplastic lesions (vs NIILs), although the sensitivity and accuracy were low.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.255.1.71","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T18:17:57Z","timestamp":1560449877000},"page":"71-77","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of diffusion-weighted magnetic resonance imaging at 3.0 Tesla for differentiation between intracranial neoplastic and noninfectious inflammatory lesions in dogs"],"prefix":"10.2460","volume":"255","author":[{"given":"Megan J.","family":"Maclellan","sequence":"first","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Ober","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Feeney","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl R.","family":"Jessen","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Am J Neuroradiol","first-page":"475","article-title":"Update on brain tumor imaging: from anatomy to physiology","volume":"27","author":"Cha","year":"2006"},{"key":"ref2","series-title":"Am J 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