{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:12:31Z","timestamp":1793985151942,"version":"4.8.0"},"reference-count":50,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo determine the prevalence of nucleic acid from selected cardiotropic pathogens in endomyocardial biopsy samples from dogs with unexplained myocardial and rhythm disorders (UMRD) and compare prevalence with that for a group of control dogs with congenital heart disease (CHD).<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n47 client-owned dogs.<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nRight ventricular endomyocardial biopsy was performed in dogs with UMRD (dilated cardiomyopathy [n = 25], atrioventricular block [6], and nonfamilial ventricular [4] and supraventricular arrhythmias [2]) or CHD (10) that required right ventricular catheterization. Biopsy samples were evaluated histologically, and PCR assays were used for detection of nucleic acid from 12 pathogens.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\n197 biopsy samples were collected from dogs with UMRD (n = 172) or CHD (25). At least 1 pathogen was detected in 21 of 37 (57%; 95% confidence interval [CI], 41% to 71%) dogs with UMRD, and canine coronavirus was detected in 1 of 10 (10%; 95% CI, 2% to 40%) dogs with CHD. Dogs with UMRD were significantly more likely than dogs with CHD to have pathogens detected in biopsy samples (OR, 11.8; 95% CI, 1.3 to 103.0). The most common pathogens in dogs with UMRD were canine distemper virus, canine coronavirus, canine parvovirus 2, and Bartonella<\/jats:italic> spp. No pathogens were detected in available blood samples from dogs with pathogens detected in biopsy samples.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nDetection of nucleic acids from selected cardiotropic pathogens in myocardial tissue from dogs with UMRD suggested a possible association between the 2. Further studies are needed to explore whether this association is causative or clinically important. (J Am Vet Med Assoc<\/jats:italic> 2019;255:1150\u20131160)<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.255.10.1150","type":"journal-article","created":{"date-parts":[[2019,11,5]],"date-time":"2019-11-05T15:16:05Z","timestamp":1572966965000},"page":"1150-1160","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of selected cardiotropic pathogens in the myocardium of adult dogs with unexplained myocardial and rhythm disorders or with congenital heart disease"],"prefix":"10.2460","volume":"255","author":[{"given":"Roberto A.","family":"Santilli","sequence":"first","affiliation":[{"name":"1Dipartimento di Cardiologia, Clinica Veterinaria Malpensa, Via Marconi, 27, 21017 Samarate, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Grego","sequence":"additional","affiliation":[{"name":"2Dipartimento di Scienze Veterinarie, L'Universita di Torino, Grugliasco, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Battaia","sequence":"additional","affiliation":[{"name":"3Ospedale Veterinario I Portoni Rossi, Via Roma, 57\/a, 40069 Zola Predosa, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Gianella","sequence":"additional","affiliation":[{"name":"2Dipartimento di Scienze Veterinarie, L'Universita di Torino, Grugliasco, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Tursi","sequence":"additional","affiliation":[{"name":"2Dipartimento di Scienze Veterinarie, L'Universita di Torino, Grugliasco, Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Di Girolamo","sequence":"additional","affiliation":[{"name":"4EBMVet, Via Sigismondo Trecchi 20, 26100 Cremona, 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