{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:22:31Z","timestamp":1793838151304,"version":"4.6.1"},"reference-count":38,"publisher":"American Veterinary Medical Association (AVMA)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo evaluate analgesic effects and complications associated with intraorbital insertion of an absorbable gelatin hemostatic sponge (AGHS) soaked with 1% ropivacaine solution following enucleation in dogs.<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n20 client-owned dogs undergoing enucleation.<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nDogs were randomly assigned to receive an AGHS soaked with 1% ropivacaine solution (n = 10) or saline (0.9% NaCl) solution (control group; 10) inserted intraorbitally prior to skin closure following enucleation. Carprofen (2 mg\/kg [0.9 mg\/lb]) was administered SC once after orotracheal extubation and then PO twice a day for 5 days. During the postoperative recovery period, apparent pain level was scored at various points with a modified short-form Glasgow Composite Pain Scale (score range, 0 to 19), and methadone was administered for rescue analgesia if any score was \u2265 5. After dogs returned home, owners recorded their behavior and apparent pain level for the first 3 days following enucleation.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nAt extubation, the median (range) pain score was significantly higher in the control group (8 [2 to 14]) versus the ropivacaine group (3 [1 to 7]). A greater proportion of dogs in the control group received methadone (7\/10 vs 1\/10) and had crying or attention-seeking behavior on the first day following enucleation (7\/10 vs 1\/10). No complications were observed in either group.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nAddition of intraorbital insertion of a ropivacaine-soaked AGHS to the analgesic protocol for dogs undergoing enucleation provided better analgesia than was achieved without this treatment as measured immediately and the first day after surgery, with no noted adverse effects.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.255.11.1255","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T19:49:17Z","timestamp":1573847357000},"page":"1255-1262","source":"Crossref","is-referenced-by-count":5,"title":["Analgesic effects of intraorbital insertion of an absorbable gelatin hemostatic sponge soaked with 1% ropivacaine solution following enucleation in dogs"],"prefix":"10.2460","volume":"255","author":[{"given":"Yael","family":"Shilo-Benjamini","sequence":"first","affiliation":[{"name":"1Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shira A.","family":"Slav","sequence":"additional","affiliation":[{"name":"1Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Kahane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishai","family":"Kushnir","sequence":"additional","affiliation":[{"name":"1Koret School of Veterinary Medicine, Robert H. Smith Faculty of Agriculture, Food and Environment, Hebrew University of Jerusalem, Rehovot 7610001, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Havi","family":"Sarfaty","sequence":"additional","affiliation":[{"name":"2EyeCare Clinic, 12 Pninim St, Neve Monosson 6019000, Israel."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Ofri","sequence":"additional","affiliation":[{"name":"1Koret School of Veterinary Medicine, Robert H. 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versus lidocaine-bupivacaine retrobulbar injections for postoperative analgesia following eye enucleation in dogs","volume":"244","author":"Ploog","year":"2014"},{"key":"ref5","series-title":"Sci World J","first-page":"686493","article-title":"Phantom eye syndrome: a review of the literature","volume":"2014","author":"Andreotti","year":"2014"},{"key":"ref6","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.cvsm.2008.06.005","article-title":"Multimodal pain management in veterinary medicine: the physiologic basis of pharmacologic therapies","volume":"38","author":"Lamont","year":"2008"},{"key":"ref7","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5326\/JAAHA-MS-7331","article-title":"2015 AAHA\/AAFP Pain Management Guidelines for Dogs and Cats","volume":"51","author":"Epstein","year":"2015"},{"key":"ref8","series-title":"Top Companion Anim Med","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1053\/j.ctsap.2007.12.007","article-title":"Regional anesthesia as an adjunct for eyelid surgery in dogs","volume":"23","author":"Giuliano","year":"2008"},{"key":"ref9","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.2460\/ajvr.75.12.1040","article-title":"Comparison of anesthetic efficacy and adverse effects associated with peribulbar injection of ropivacaine performed with and without ultrasound guidance in dogs","volume":"75","author":"Wagatsuma","year":"2014"},{"key":"ref10","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"174","DOI":"10.2460\/javma.237.2.174","article-title":"Effectiveness of injection of local anesthetic into the retrobulbar space for postoperative analgesia following eye enucleation in dogs","volume":"237","author":"Myrna","year":"2010"},{"key":"ref11","series-title":"Vet Ophthalmol","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/vop.12259","article-title":"Comparison of two bupivacaine delivery methods to control postoperative pain after enucleation in dogs","volume":"18","author":"Chow","year":"2015"},{"key":"ref12","series-title":"Vet Ther","first-page":"E1","article-title":"Evaluation of topical epidural morphine for postoperative analgesia following hemilaminectomy in dogs","volume":"10","author":"Wehrenberg","year":"2009"},{"key":"ref13","series-title":"Lumb and Jones\u2019 veterinary anesthesia and analgesia","first-page":"332","article-title":"Local anesthetics","author":"Rioja Garcia","year":"2015"},{"key":"ref14","series-title":"Anesth Analg","first-page":"794","article-title":"Comparative systemic toxicity of convulsant and supraconvulsant doses of intravenous ropivacaine, bupivacaine, and lidocaine in the conscious dog","volume":"69","author":"Feldman","year":"1989"},{"key":"ref15","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1097\/00000539-200112000-00046","article-title":"The differential effects of stereoisomers of ropivacaine and bupivacaine on cerebral pial arterioles in dogs","volume":"93","author":"Iida","year":"2001"},{"key":"ref16","series-title":"Anesth Analg","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1213\/00000539-200202000-00006","article-title":"Ropivacaine undergoes slower systemic absorption from the caudal epidural space in children than bupivacaine","volume":"94","author":"Karmakar","year":"2002"},{"key":"ref17","series-title":"Veterinary ophthalmic surgery","first-page":"51","article-title":"Surgery of the orbit","author":"Gelatt","year":"2011"},{"key":"ref18","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2460\/javma.242.5.631","article-title":"Effects of intratesticular injection of bupivacaine and epidural administration of morphine in dogs undergoing castration","volume":"242","author":"Perez","year":"2013"},{"key":"ref19","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1532-950X.1998.tb00539.x","article-title":"Hemodynamic effects of medetomidine in the dog: a dose titration study","volume":"27","author":"Pypendop","year":"1998"},{"key":"ref20","series-title":"Vet Anaesth Analg","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/j.vaa.2016.12.059","article-title":"Psoas compartment and sacral plexus block via electrostimulation for pelvic limb amputation in dogs","volume":"44","author":"Congdon","year":"2017"},{"key":"ref21","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"2154","DOI":"10.2460\/ajvr.2005.66.2154","article-title":"Application of a scaling model to establish and validate an interval level pain scale for assessment of acute pain in dogs","volume":"66","author":"Morton","year":"2005"},{"key":"ref22","series-title":"Vet Rec","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1136\/vr.162.13.403","article-title":"Application of a modified form of the Glasgow pain scale in a veterinary teaching centre in the Netherlands","volume":"162","author":"Murrell","year":"2008"},{"key":"ref23","series-title":"PeerJ","doi-asserted-by":"publisher","first-page":"e341","DOI":"10.7717\/peerj.341","article-title":"The challenge of evaluating pain and a pre-incisional local anesthetic block","volume":"2","author":"McKune","year":"2014"},{"key":"ref24","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1111\/vsu.12406","article-title":"Comparison of short-term postoperative analgesia by epidural, femoral nerve block, or combination femoral and sciatic nerve block in dogs undergoing tibial plateau leveling osteotomy","volume":"44","author":"McCally","year":"2015"},{"key":"ref25","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/jsap.12674","article-title":"Perceptions and opinions of Canadian pet owners about anaesthesia, pain and surgery in small animals","volume":"58","author":"Steagall","year":"2017"},{"key":"ref26","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/vsu.12753","article-title":"Perceptions and opinions of pet owners in the United States about surgery, pain management, and anesthesia in dogs and cats","volume":"47","author":"Simon","year":"2018"},{"key":"ref27","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/jvim.12004","article-title":"Comparison of force plate gait analysis and owner assessment of pain using the Canine Brief Pain Inventory in dogs with osteoarthritis","volume":"27","author":"Brown","year":"2013"},{"key":"ref28","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.2460\/javma.251.12.1405","article-title":"Psychometric properties of the Canine Symptom Assessment Scale, a multidimensional owner-reported questionnaire instrument for assessment of physical symptoms in dogs with solid tumors","volume":"251","author":"Giuffrida","year":"2017"},{"key":"ref29","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0172822","DOI":"10.1371\/journal.pone.0172822","article-title":"Comparison of harmonic blade versus traditional approach in canine patients undergoing spinal decompressive surgery for naturally occurring thoracolumbar disk extrusion","volume":"12","author":"Hettlich","year":"2017"},{"key":"ref30","series-title":"Am J Vet Res","doi-asserted-by":"publisher","first-page":"601","DOI":"10.2460\/ajvr.72.5.601","article-title":"Reliability and validity of a visual analogue scale used by owners to measure chronic pain attributable to osteoarthritis in their 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Ophthalmol","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1463-5224.2012.01053.x","article-title":"Suspected brainstem anesthesia following retrobulbar block in a cat","volume":"16","author":"Oliver","year":"2013"},{"key":"ref35","series-title":"Ethiop J Health Sci","doi-asserted-by":"publisher","first-page":"589","DOI":"10.4314\/ejhs.v26i6.13","article-title":"Brainstem anesthesia after retrobulbar block: a case report and review of literature","volume":"26","author":"Tolesa","year":"2016"},{"key":"ref36","series-title":"J Clin Anesth","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/S0952-8180(03)00025-4","article-title":"Apnea and seizures following retrobulbar local anesthetic injection","volume":"15","author":"Moorthy","year":"2003"},{"key":"ref37","series-title":"Int J Nanomedicine","first-page":"1499","article-title":"Hemostatic absorbable gelatin sponge loaded with 5-fluorouracil for treatment of 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