{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:19:35Z","timestamp":1773029975561,"version":"3.50.1"},"reference-count":31,"publisher":"American Veterinary Medical Association (AVMA)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To identify factors associated with dehiscence and mortality rates following gastrointestinal surgery in dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>ANIMALS<\/jats:title>\n<jats:p>170 client-owned dogs that underwent gastrointestinal surgery from 2010 to 2016.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Medical records of all included dogs were reviewed to collect information on preoperative (breed, sex, age, body weight, American Society of Anesthesiologists [ASA] physical status classification, emergency status, and plasma lactate concentration), intraoperative (indication for surgery, type of surgery, and whether bacterial peritonitis was identified), and postoperative (development of dehiscence and survival status at 2 weeks after surgery) factors. Preoperative and intraoperative factors were evaluated for associations among each other and with postoperative factors.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Univariate analyses revealed that preoperative plasma lactate concentration increased with increasing ASA status, and lactate concentrations were significantly higher for nonsurvivors (mean \u00b1 SD, 4.6 \u00b1 3.7 mmol\/L) than for survivors (2.4 \u00b1 1.7 mmol\/L). Multivariate analysis controlling for age, body weight, and plasma lactate concentration revealed that dogs with an ASA status \u2265 3 were more likely to develop dehiscence after gastrointestinal surgery than were dogs with a lower ASA status (OR, 17.77; 95% confidence interval, 2.17 to 144.06). Multivariate analysis also revealed that dogs with an ASA status \u2265 3 or high lactate concentration were less likely to survive than were other dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>These findings regarding ASA status and preoperative plasma lactate concentration and their associations with outcome may help clinicians to determine and provide optimal perioperative care to dogs requiring gastrointestinal surgery as well as to inform owners about prognosis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.255.5.569","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T14:10:17Z","timestamp":1566310217000},"page":"569-573","source":"Crossref","is-referenced-by-count":18,"title":["Factors associated with dehiscence and mortality rates following gastrointestinal surgery in dogs"],"prefix":"10.2460","volume":"255","author":[{"given":"Sukhjit S.","family":"Gill","sequence":"first","affiliation":[{"name":"1VCA West Los Angeles Animal Specialty Hospital, 1900 S Sepulveda Blvd, Los Angeles, CA 90025."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole J.","family":"Buote","sequence":"additional","affiliation":[{"name":"1VCA West Los Angeles Animal Specialty Hospital, 1900 S Sepulveda Blvd, Los Angeles, CA 90025."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan W.","family":"Peterson","sequence":"additional","affiliation":[{"name":"1VCA West Los Angeles Animal Specialty Hospital, 1900 S Sepulveda Blvd, Los Angeles, CA 90025."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Bergman","sequence":"additional","affiliation":[{"name":"2VCA Clinical Studies, 12401 W Olympic Dr, Los Angeles, CA 90064."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Textbook of small animal surgery","first-page":"593","article-title":"Small intestine","author":"Orshner","year":"1993"},{"key":"ref2","series-title":"Current techniques in small animal surgery","first-page":"276","article-title":"Enterotomy","author":"Ellison","year":"2014"},{"key":"ref3","series-title":"J Am Anim Hosp Assoc","first-page":"70","article-title":"Prevalence of small intestinal dehiscence and associated clinical factors: a retrospective study of 121 dogs","volume":"28","author":"Allen","year":"1992"},{"key":"ref4","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2460\/javma.2003.223.73","article-title":"Risk factors for leakage following intestinal anastomosis in dogs and cats: 115 cases (1991\u20132000)","volume":"223","author":"Ralphs","year":"2003"},{"key":"ref5","series-title":"J Am Anim Hosp Assoc","first-page":"469","article-title":"Mortality and morbidity of small and large intestinal surgery in dogs and cats: 74 cases (1980\u20131992)","volume":"30","author":"Wylie","year":"1994"},{"key":"ref6","series-title":"J Am Vet Assoc","doi-asserted-by":"publisher","first-page":"486","DOI":"10.2460\/javma.238.4.486","article-title":"Identification of risk factors for septic peritonitis and failure to survive following gastrointestinal surgery in dogs","volume":"238","author":"Grimes","year":"2011"},{"key":"ref7","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"254","DOI":"10.5326\/JAAHA-MS-6111","article-title":"Evaluation of data from 35 dogs pertaining to dehiscence following intestinal resection and anastomosis","volume":"50","author":"Mouat","year":"2014"},{"key":"ref8","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1748-5827.2005.tb00326.x","article-title":"Complications following full-thickness small intestinal biopsy in 66 dogs: a retrospective study","volume":"46","author":"Shales","year":"2005"},{"key":"ref9","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1532-950X.1990.tb01188.x","article-title":"Complications of small intestinal biopsy in hypoalbuminaemic dogs","volume":"19","author":"Harvey","year":"1990"},{"key":"ref10","series-title":"J Am Coll Surg","first-page":"364","article-title":"A multivariate analysis of factors contributing to leakage of intestinal anastomoses","volume":"184","author":"Golub","year":"1997"},{"key":"ref11","series-title":"J Vet Emerg Crit Care","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/j.1476-4431.1995.tb00026.x","article-title":"Prognostic indicators of survival in high-risk canine surgery patients","volume":"5","author":"Hardie","year":"1995"},{"key":"ref12","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/00000658-198708000-00004","article-title":"Gastrointestinal anastomoses: factors affecting early complications","volume":"206","author":"Jex","year":"1987"},{"key":"ref13","series-title":"Int J Colorectal Dis","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00384-007-0399-3","article-title":"Incidence, consequences, and risk factors for anastomotic dehiscence after colorectal surgery: a prospective monocentric study","volume":"23","author":"Buchs","year":"2008"},{"key":"ref14","series-title":"Dis Colon Rectum","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1007\/s10350-006-0703-2","article-title":"Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors","volume":"49","author":"Choi","year":"2006"},{"key":"ref15","series-title":"J Pak Med Assoc","first-page":"166","article-title":"Factors affecting anastomotic leak after colorectal anastomosis in patients without protective stoma in tertiary care hospital","volume":"64","author":"Sultan","year":"2014"},{"key":"ref16","series-title":"ASA physical status classification system","year":"2019"},{"key":"ref17","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0195-5616(00)50039-4","article-title":"Gastrointestinal emergencies","volume":"30","author":"Aronson","year":"2000"},{"key":"ref18","series-title":"J Crit Care","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.jcrc.2016.09.023","article-title":"Absolute lactate value vs relative reduction as a predictor of mortality in severe sepsis and septic shock","volume":"37","author":"Lokhandwala","year":"2017"},{"key":"ref19","series-title":"J Vet Emerg Crit Care (San Antonio)","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/vec.12234","article-title":"Plasma lactate concentrations in septic peritonitis: a retrospective study of 83 dogs (2007\u20132012)","volume":"25","author":"Cortellini","year":"2015"},{"key":"ref20","series-title":"West J Emerg Med","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.5811\/westjem.2015.10.27577","article-title":"Lactate clearance predicts survival among patients in the emergency department with severe sepsis","volume":"16","author":"Bhat","year":"2015"},{"key":"ref21","series-title":"Mater Sociomed","doi-asserted-by":"publisher","first-page":"57","DOI":"10.5455\/msm.2016.28.57-60","article-title":"The role of lactate clearance as a predictor of organ dysfunction and mortality in patients with severe sepsis","volume":"28","author":"Bolvardi","year":"2016"},{"key":"ref22","series-title":"Ann Intensive Care","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/2110-5820-3-3","article-title":"Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in intensive care unit: an observational study","volume":"3","author":"Marty","year":"2013"},{"key":"ref23","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1097\/00000658-197305000-00002","article-title":"Factors contributing to leakage of colonic anastomoses","volume":"177","author":"Schrock","year":"1973"},{"key":"ref24","series-title":"Compend Contin Educ Vet","first-page":"E1","article-title":"Septic peritonitis","volume":"32","author":"Culp","year":"2010"},{"key":"ref25","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1532-950X.1986.tb00169.x","article-title":"Open abdominal drainage in the treatment of generalized peritonitis in 25 dogs and cats","volume":"15","author":"Woolfson","year":"1986"},{"key":"ref26","series-title":"J Am Vet Med Assoc","first-page":"100","article-title":"Open peritoneal drainage for treatment of contaminated peritoneal cavity and septic peritonitis in dogs and cats: 24 cases (1980\u20131986)","volume":"191","author":"Greenfield","year":"1987"},{"key":"ref27","series-title":"J Vet Emerg Crit Care","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1476-4431.2000.tb00011.x","article-title":"Potential prognostic indicators in diffuse peritonitis treated with open peritoneal drainage in the canine patient","volume":"10","author":"Winkler","year":"2000"},{"key":"ref28","series-title":"J Am Vet Med Assoc","doi-asserted-by":"publisher","first-page":"789","DOI":"10.2460\/javma.2001.219.789","article-title":"Use of closed-suction drains to treat generalized peritonitis in dogs and cats: 40 cases (1997\u20131999)","volume":"219","author":"Mueller","year":"2001"},{"key":"ref29","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1053\/jvet.2002.31043","article-title":"Open peritoneal drainage versus primary closure for the treatment of septic peritonitis in dogs and cats: 42 cases (1993\u20131999)","volume":"31","author":"Staatz","year":"2002"},{"key":"ref30","series-title":"Vet Surg","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1111\/j.1532-950X.2014.12258.x","article-title":"Closed suction drainage for treatment of septic peritonitis of confirmed gastrointestinal origin in 20 dogs","volume":"43","author":"Adams","year":"2014"},{"key":"ref31","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/jsap.12271","article-title":"Linear versus non-linear gastrointestinal foreign bodies in 499 dogs: clinical presentation, management and short-term outcome","volume":"55","author":"Hobday","year":"2014"}],"container-title":["Journal of the American Veterinary Medical 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