{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:22:20Z","timestamp":1771518140482,"version":"3.50.1"},"reference-count":11,"publisher":"American Veterinary Medical Association (AVMA)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2019,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>CASE DESCRIPTION<\/jats:title>\n<jats:p>A 10-year-old spayed female Golden Retriever was examined because of a 3-month history of lethargy, anorexia, and stumbling gait.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>CLINICAL FINDINGS<\/jats:title>\n<jats:p>A splenic mass was identified on abdominal radiography and ultrasonography, and results of clinicopathologic findings indicated nonregenerative anemia, leukocytosis, and high serum C-reactive protein (CRP) concentration. To further investigate the cause of the dog's high serum CRP concentration, radiography and arthrocentesis were performed bilaterally on the carpal and stifle joints. On the basis of results, anemia of chronic disease associated with polyarthritis caused by the localized splenic mass was suspected.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>TREATMENT AND OUTCOME<\/jats:title>\n<jats:p>After splenectomy, there were improvements in the dog's clinical signs, polyarthritis, nonregenerative anemia, and serum CRP concentration. The splenic mass was histologically diagnosed as a nonneoplastic splenic hyperplastic nodule with evidence of omental adhesion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Findings indicated that nonneoplastic splenic hyperplastic nodules could result in reactive polyarthritis, although such nodules have not to our knowledge been described previously as an underlying cause of polyarthritis. Therefore, veterinarians should investigate for nonneoplastic splenic hyperplastic nodules in addition to other typical underlying causes when treating dogs with polyarthritis.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.255.8.939","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T19:16:43Z","timestamp":1569957403000},"page":"939-941","source":"Crossref","is-referenced-by-count":1,"title":["Resolution of reactive arthritis after splenectomy in a dog with a nonneoplastic splenic hyperplastic nodule"],"prefix":"10.2460","volume":"255","author":[{"given":"Masashi","family":"Yuki","sequence":"first","affiliation":[{"name":"1Yuki Animal Hospital, 2\u201399 Kiba-cho, Minato-ku, Aichi 455\u20130021, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Kainuma","sequence":"additional","affiliation":[{"name":"1Yuki Animal Hospital, 2\u201399 Kiba-cho, Minato-ku, Aichi 455\u20130021, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Naitoh","sequence":"additional","affiliation":[{"name":"1Yuki Animal Hospital, 2\u201399 Kiba-cho, Minato-ku, Aichi 455\u20130021, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reina","family":"Aoyama","sequence":"additional","affiliation":[{"name":"1Yuki Animal Hospital, 2\u201399 Kiba-cho, Minato-ku, Aichi 455\u20130021, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hirano","sequence":"additional","affiliation":[{"name":"1Yuki Animal Hospital, 2\u201399 Kiba-cho, Minato-ku, Aichi 455\u20130021, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1939-1676.2005.tb02743.x","article-title":"Suppurative, nonspetic polyarthropathy in dogs","volume":"19","author":"Rondeau","year":"2005"},{"key":"ref2","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1111\/j.1748-5827.1987.tb01316.x","article-title":"Immune-based non-erosive inflammatory joint disease of the dog. 3. Canine idiopathic polyarthritis","volume":"28","author":"Bennett","year":"1987"},{"key":"ref3","series-title":"Eur J Companion Anim Pract","first-page":"119","article-title":"Canine immune-mediated polyarthritis","volume":"17","author":"Kohn","year":"2007"},{"key":"ref4","series-title":"Can Vet J","first-page":"1195","article-title":"Canine immune-mediated polyarthritis: clinical and laboratory findings in 83 cases in western Canada (1991\u20132001)","volume":"49","author":"Stull","year":"2008"},{"key":"ref5","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5326\/JAAHA-MS-5744","article-title":"Canine immune-mediated polyarthritis: part 1: pathophysiology","volume":"48","author":"Johnson","year":"2012"},{"key":"ref6","series-title":"Textbook of veterinary internal medicine: disease of the dog and cat","first-page":"861","article-title":"Immune-mediated polyarthritis and other polyarthrides","author":"Stone","year":"2017"},{"key":"ref7","series-title":"J Small Anim Pract","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1748-5827.2006.00162.x","article-title":"Panniculitis, polyarthritis and osteomyelitis associated with pancreatic neoplasia in two dogs","volume":"47","author":"Gear","year":"2006"},{"key":"ref8","series-title":"Small animal clinical oncology","first-page":"51","article-title":"The pathology of neoplasia","author":"Ehrhart","year":"2013"},{"key":"ref9","series-title":"Vet Clin Pathol","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1111\/j.1939-165X.2005.tb00019.x","article-title":"Acute phase proteins in dogs and cats: current knowledge and future perspectives","volume":"34","author":"Ceron","year":"2005"},{"key":"ref10","series-title":"BMC Vet Res","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1186\/s12917-016-0868-4","article-title":"Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs","volume":"12","author":"Hillstr\u00f6m","year":"2016"},{"key":"ref11","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1111\/jvim.12351","article-title":"Serum biomarker of clinical and cytologic response in dogs with idiopathic immune-mediated polyarthropathy","volume":"28","author":"Foster","year":"2014"}],"container-title":["Journal of the American Veterinary Medical Association"],"original-title":[],"link":[{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/255\/8\/javma.255.8.939.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/255\/8\/javma.255.8.939.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/avmajournals.avma.org\/downloadpdf\/journals\/javma\/255\/8\/javma.255.8.939.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:38:53Z","timestamp":1696552733000},"score":1,"resource":{"primary":{"URL":"https:\/\/avmajournals.avma.org\/view\/journals\/javma\/255\/8\/javma.255.8.939.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":11,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.2460\/javma.255.8.939","relation":{},"ISSN":["0003-1488"],"issn-type":[{"value":"0003-1488","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,15]]}}}