{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T16:39:28Z","timestamp":1780418368524,"version":"3.54.1"},"reference-count":19,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo describe response rate, tumor progression, patient survival times, prognostic factors associated with tumor progression and patient survival times, and radiation toxicoses (acute and latent) in dogs treated with curative-intent stereotactic body radiation therapy (SBRT) for soft tissue sarcomas (STS).<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n35 client-owned dogs with STS treated with curative-intent SBRT between October 2011 and May 2017.<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nMedical records were reviewed to identify dogs that underwent SBRT. Dogs with oral tumors, hemangiosarcoma, or histiocytic sarcoma were excluded. Data collected included patient-, STS-, and SBRT-related information, including follow-up information pertaining to tumor progression and patient survival time for \u2265 6 months, unless tumor progression or patient death occurred sooner.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nObjective measurements allowing for evaluation of tumor response were available for 28 dogs, of which 13 (46%) had either a partial (10\/28 [36%]) or complete (3\/28 [11%]) response. Twenty-four dogs died, and the medians for progression-free survival time, time to progression of disease, overall survival time, and disease-specific survival time were 521, 705, 713, and 1,149 days, respectively. Low histologic grade and extremity locations of STSs were positive prognostic factors for patient survival times. Acute adverse effects were limited to skin, and 1 dog underwent limb amputation because of a nonhealing wound.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nResults indicated that SBRT for STS was well tolerated in most dogs and provided local tumor control. Additional studies are needed to determine the best SBRT protocol for treatment of STSs in dogs.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.256.1.102","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T14:28:56Z","timestamp":1576506536000},"page":"102-110","source":"Crossref","is-referenced-by-count":12,"title":["Stereotactic body radiation therapy for treatment of soft tissue sarcomas in 35 dogs"],"prefix":"10.2460","volume":"256","author":[{"given":"Jerome","family":"Gagnon","sequence":"first","affiliation":[{"name":"1Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique N.","family":"Mayer","sequence":"additional","affiliation":[{"name":"1Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tayler","family":"Belosowsky","sequence":"additional","affiliation":[{"name":"1Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Neal","family":"Mauldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl L.","family":"Waldner","sequence":"additional","affiliation":[{"name":"2Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK S7N 5B4 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Withrow and MacEwen's small animal clinical oncology","first-page":"356","article-title":"Soft tissue sarcomas","author":"Liptak","year":"2013"},{"key":"ref2","series-title":"J Am Vet Med Assoc","first-page":"1147","article-title":"Prognostic factors for surgical treatment of soft-tissue sarcomas in dogs: 75 cases (1986\u20131996)","volume":"211","author":"Kuntz","year":"1997"},{"key":"ref3","series-title":"Int J 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