{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T11:29:45Z","timestamp":1793100585479,"version":"4.5.0"},"reference-count":35,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"Abstract<\/jats:title>\n\nCASE DESCRIPTION<\/jats:title>\n3 dogs with chronic sinonasal signs (sneezing, nasal discharge, or epistaxis [or a combination of signs]) were examined.<\/jats:p>\n<\/jats:sec>\n\nCLINICAL FINDINGS<\/jats:title>\nFor all 3 dogs, CT revealed variable degrees of nasal turbinate destruction and frontal sinus involvement with cribriform plate lysis. Fungal plaques were detected during rhinoscopy or sinusoscopy. Results of fungal culture (2 dogs) or cytologic examination of a plaque specimen (1 dog) supported a diagnosis of sinonasal aspergillosis.<\/jats:p>\n<\/jats:sec>\n\nTREATMENT AND OUTCOME<\/jats:title>\nAll dogs underwent surgical rhinotomy or sinusotomy (or both) for fungal plaque debridement followed by oral treatment with voriconazole and periodic physical examinations, clinicopathologic analyses, and assessments of serum drug concentrations for a period \u2265 22 weeks. All dogs had considerable to complete reduction of their clinical signs and tolerated voriconazole treatment with minimal adverse effects. Adverse effects included development of reversible neurotoxicosis (associated with high serum voriconazole concentration) and mildly high serum liver enzyme activities. The dosage of voriconazole administered to achieve therapeutic serum concentrations (2.5 to 3.3 mg\/kg [1.1 to 1.5 mg\/lb], PO, q 12 h) was substantially lower than dosages suggested by previously published studies in dogs. The 3 dogs remained clinically normal or had mild clinical signs after voriconazole discontinuation for follow-up times of 6 to 15 months.<\/jats:p>\n<\/jats:sec>\n\nCLINICAL RELEVANCE<\/jats:title>\nFindings in these 3 dogs indicated that surgical fungal plaque debridement followed by oral treatment with voriconazole may be an effective treatment option for dogs with sinonasal aspergillosis and cribriform plate lysis. Further evaluation of this treatment regimen with repeated CT examinations and longer follow-up times is warranted.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.256.1.111","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T14:28:56Z","timestamp":1576506536000},"page":"111-116","source":"Crossref","is-referenced-by-count":5,"title":["Oral administration of voriconazole with surgical fungal plaque debridement for the treatment of sinonasal aspergillosis with cribriform plate lysis in three dogs"],"prefix":"10.2460","volume":"256","author":[{"given":"Ryan N.","family":"Bray","sequence":"first","affiliation":[{"name":"1BluePearl Pet Hospital, 455 Abernathy Rd NE, Sandy Springs, GA 30328"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantel L.","family":"Raghu","sequence":"additional","affiliation":[{"name":"2Care Center, 6995 E Kemper Rd, Cincinnati, OH 45249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison S.","family":"Leuin","sequence":"additional","affiliation":[{"name":"3Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin A.","family":"Barry-Heffernan","sequence":"additional","affiliation":[{"name":"4BluePearl Pet Hospital, 29080 Inkster Rd, Southfeld, MI 48034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Pritchard","sequence":"additional","affiliation":[{"name":"3Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciw326","article-title":"Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases 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