{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T01:31:06Z","timestamp":1780709466959,"version":"3.54.1"},"reference-count":41,"publisher":"American Veterinary Medical Association (AVMA)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["javma"],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"Abstract<\/jats:title>\n\nOBJECTIVE<\/jats:title>\nTo determine the frequency and severity of thrombocytosis and thromboelastographic evidence of hypercoagulability during the first 2 weeks after splenectomy in dogs with splenic masses and to investigate relationships between platelet counts and thromboelastography values.<\/jats:p>\n<\/jats:sec>\n\nANIMALS<\/jats:title>\n34 dogs undergoing splenectomy for splenic masses.<\/jats:p>\n<\/jats:sec>\n\nPROCEDURES<\/jats:title>\nBlood samples for platelet counts and thromboelastography were obtained at induction of anesthesia (day 0) prior to splenectomy and on days 2, 7, and 14.<\/jats:p>\n<\/jats:sec>\n\nRESULTS<\/jats:title>\nMean platelet counts were 167.9 \u00d7 103<\/jats:sup>\/\u03bcL, 260.4 \u00d7 103<\/jats:sup> \u03bc\/L, 715.9 \u00d7 103<\/jats:sup>\/\u03bcL, and 582.2 \u00d7 103<\/jats:sup>\/\u03bcL on days 0, 2, 7, and 14, respectively, and were significantly higher at all postoperative assessment points than on day 0. Thrombocytosis was observed in 3% (1\/34), 6% (2\/33), 81% (21\/26), and 69% (18\/26) of dogs on days 0, 2, 7, and 14. Platelet counts > 1,000 \u00d7 103<\/jats:sup>\/\u03bcL were observed in 1 dog on day 2 and in 5 dogs on day 7. One or more thromboelastography values suggestive of hypercoagulability were observed in 45% (15\/33), 84% (26\/31), 89% (24\/27), and 84% (21\/25) of dogs on days 0, 2, 7, and 14. At each assessment point, higher platelet counts were correlated with thromboelastography values suggestive of hypercoagulability.<\/jats:p>\n<\/jats:sec>\n\nCONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\nMarked thrombocytosis and thromboelastography values suggestive of hypercoagulability were common during the first 2 weeks after splenectomy for the dogs of this study. If present, hypercoagulability could increase the risk for development of postsplenectomy thrombotic conditions such as portal system thrombosis and pulmonary thromboembolism.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/javma.256.1.85","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T14:28:56Z","timestamp":1576506536000},"page":"85-92","source":"Crossref","is-referenced-by-count":18,"title":["Postoperative thrombocytosis and thromboelastographic evidence of hypercoagulability in dogs undergoing splenectomy for splenic masses"],"prefix":"10.2460","volume":"256","author":[{"given":"Whitney E.","family":"Phipps","sequence":"first","affiliation":[{"name":"1Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle M.","family":"de Laforcade","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A.","family":"Barton","sequence":"additional","affiliation":[{"name":"2Division of Biostatistics, Department of Quantitative Health Science, University of Massachusetts Medical School, Worcester, MA 01655"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Berg","sequence":"additional","affiliation":[{"name":"1Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1272","reference":[{"key":"ref1","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1939-1676.1997.tb00085.x","article-title":"Pathologic factors affecting post-splenectomy survival in dogs","volume":"11","author":"Spangler","year":"1997"},{"key":"ref2","series-title":"J Vet Intern Med","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1939-1676.1989.tb03092.x","article-title":"Splenomegaly in dogs: predictors of neoplasia and survival after splenectomy","volume":"3","author":"Johnson","year":"1989"},{"key":"ref3","series-title":"J Am Anim Hosp Assoc","doi-asserted-by":"publisher","first-page":"518","DOI":"10.5326\/0390518","article-title":"Acute nontraumatic hemoabdomen in the dog. 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